DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and Mmel1

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	776	Identity:	313/776 - (40%)
Similarity:	466/776 - (60%)	Gaps:	56/776 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 RRRL------LVLAIAFTVLGAAIGALAIYFA--------------SVHQRCHLYRLEPDNDDRP 154
            ||||      |::.:...::||.: .|.::::              |.|:|..:.|:..|:..:
  Rat    19 RRRLGFVECGLLVLLTLLLMGAIV-TLGVFYSIGKQLPLLNSLLHVSRHERTVVKRVLRDSSQK- 81

  Fly   155 NGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSS 219
                           .:||.|..||..||.:|..||.:..||::|:|||||.|.:.|.|||..|.
  Rat    82 ---------------SDICTTPSCVIAAARILQNMDQSKKPCDNFYQYACGGWLRHHVIPETNSR 131

  Fly   220 ISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGW 284
            .|.|::|.|:.:|||:.|||:. ..:...|..||||.::|||:...|.|..:..|..||..:|||
  Rat   132 YSVFDILRDELEVILKGVLEDS-SVQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLNVLDMIGGW 195

  Fly   285 PVIERNWS----PPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRD 345
            ||....|:    |..:|  ||.:..|...::..|:|:|::..||:|||.:::.:||....:|||:
  Rat   196 PVAMDKWNETMGPKWEL--ERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSRE 258

  Fly   346 YYLKESSANDRRAYHRYMTQVALLLGAD---PA---TAAAELEKVVLFETQLVNVSLPEADRHDT 404
            ||.||.|...|.||.::||.||.:|..|   |.   ....|:.:|:..||.|.|.::|:..|||.
  Rat   259 YYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMAQVLHLETHLANATVPQEKRHDV 323

  Fly   405 SLVYRKMLLPELQEL--VPEVQWQEYLQAALGP-GIPLQEDEPLVTYGLHYLTEMGKILAHTDRR 466
            :.:|.:|.|.||||.  :....|..::|..|.. .:.|..:|.:|.||:.||..:.:|:.....:
  Rat   324 TALYHRMGLEELQERFGLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIPYLENLEEIIDVFPAQ 388

  Fly   467 VVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRD 531
            .:.||::||||:..:..:...::..||::||.|.|...|..||.:||.:.|..:..|||:|:|:.
  Rat   389 TLQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTMEEVRWRECVSYVNSNMESAVGSLYIKR 453

  Fly   532 NFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPE--LLTNATELE 594
            .|:::||.:..|:|..||:.|.:.|.|.:|||:|::..|:|||.::.|:||||:  |..|...|:
  Rat   454 AFSKDSKSIVSELIEKIRSVFVDNLDELNWMDEESKKKAQEKALNIREQIGYPDYILEDNNRHLD 518

  Fly   595 QEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGI 659
            :||.:||...|.:..|.|..|:..:::.|:.||:.||:..|....|||||||:||:|.|||||||
  Rat   519 EEYSSLTFSEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNLIVFPAGI 583

  Fly   660 LQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVID 724
            |||.|:|:..|::||:||||:||||||||||||.||.|||.|||:.||:|.:...||:::||:|.
  Rat   584 LQPPFFSKDQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFRQQSQCMIY 648

  Fly   725 QYSRYKINEVD-MFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLN 788
            |||.:.....| ..::|..|.|||||||||::||::||.:|....||:|:|||||:|:.||||:|
  Rat   649 QYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLQWLAEGGRDQRLPGLNLTYAQLFFIN 713

  Fly   789 YAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            |||:||||.|||.|:..|::.||||...||||.|.|...|:.|:.||.||.|:|..:|.:|
  Rat   714 YAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHPMNRCRIW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	288/668 (43%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21		1/1 (100%)
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	288/668 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	257	1.000	Domainoid score	I1948
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	578	1.000	Inparanoid score	I998
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	1	1.000	-	-		otm45995
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2533
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.880