Protein Alignment Nep1 and nep-25

DIOPT Version :10

• Sequence 1: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_495164.2
• Gene: nep-25 / 191543
• WormBaseID: WBGene00022874
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 694
• Identity: 127/694 - (18%)
• Similarity: 226/694 - (32%)
• Gaps: 243/694 - (35%)

  Fly   176 QECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEE 240
            ||.::..|      |.:.|||.||:.:.| .|.......||.|.:
 Worm    29 QEHIKKHA------DFSVDPCVDFYAHVC-PWKVERYFMEDLSKL-------------------- 66

  Fly   241 PIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQ 305
                   ||.:.||...|.    |:..|........:.::|             ..|::|:|..:
 Worm    67 -------KAGMVAKYRKKH----PKFDKFKGEDAFAIAEAL-------------KQLNIEQLKSE 107

  Fly   306 LRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSA----NDRRAYHRYMTQV 366
            .:  .|:|.:...::.|.|..:..|:   |::.:  |..:.|..|..|    .:......|.|..
 Worm   108 CK--PSKPRLSSFFISAQDNRTIENV---DEVLF--PGFENYPCEEKAAIIIKEVGEIEDYTTTR 165

  Fly   367 ALLLGADPATAAAEL-EKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQ 430
            ::|:.|......::| ||:.:...:|.|             .::.::..|    :.:..|.:..:
 Worm   166 SVLVSAVNGFITSKLVEKLDVKARKLFN-------------KFKSVISKE----IIKTPWAKNYK 213

  Fly   431 AALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEF 495
            |       :::          |:..:..|...|                               |
 Worm   214 A-------IEQ----------YVEALSNITFRT-------------------------------F 230

  Fly   496 RKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAEND 560
            ..:.:.::.....:....:...|||.||         |:|.:.|:.
 Worm   231 ADVRITVKKSMELYESTEKDCRKKLDVA---------FSQPTAELV------------------- 267

  Fly   561 WMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRL 625
                 .:.||..||:         |||....|            |.|..:...||
 Worm   268 -----CKGVATRKAE---------ELLDEPIE------------DIFPQDQAGIL---------- 296

  Fly   626 LRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHG- 689
                  |:.|....:..|:.|..|:..::........|           ||.||..:.|||.|.
 Worm   297 ------KDVWQMFNSFDNSVYIGNEFLLLLNTDYFSDL-----------YGSIGFSMIHEIMHTL 344

  Fly   690 -FDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSR--------YKINEVDMFMDGRMTQG 745
             |||  ...||..:.: |..||         .||.||..:        .:::.:....:..:|..
 Worm   345 VFDD--NDLDKPLSKL-WTKNA---------DCVKDQALKTCETFPTVTEMHNMKPACNTTVTFE 397

  Fly   746 ENIADNGGLKQAFRAYKKWETLHGREQQLPGLN-MTHDQLFFLNYAQIWCGSMRPEDALTKI--R 807
            |:.||....:.|:|.|   |..:.|:..:|... :...||||...|..:|.    :|.::::  :
 Worm   398 EDAADLAAYRIAWRIY---ENSYARKTVVPNYEALDKKQLFFYGAAVFFCN----QDGMSRVPFQ 455

  Fly   808 SAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTM--NPAEKCSVW 849
            :..||..:.||...:|..:.|:.|:||.....|  |.|:.|.::
 Worm   456 NLAHSNNYQRVNSLMSQMKQFSDAFKCKPTDKMITNRAKHCELY 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_511056.2	M13	194..847	CDD:341056	122/672 (18%)
nep-25	NP_495164.2	Peptidase_M13	308..496	CDD:279739	53/217 (24%)