Protein Alignment Nep1 and nep-25

DIOPT Version :9

• Sequence 1: NP_001284925.1
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_495164.2
• Gene: nep-25 / 191543
• WormBaseID: WBGene00022874
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 701
• Identity: 129/701 - (18%)
• Similarity: 227/701 - (32%)
• Gaps: 257/701 - (36%)

  Fly   176 QECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEE 240
            ||.::..|      |.:.|||.||:.:.| .|.......||.|.:
 Worm    29 QEHIKKHA------DFSVDPCVDFYAHVC-PWKVERYFMEDLSKL-------------------- 66

  Fly   241 PIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQ 305
                   ||.:.||...|.    |:..|........:.::|             ..|::|:|..:
 Worm    67 -------KAGMVAKYRKKH----PKFDKFKGEDAFAIAEAL-------------KQLNIEQLKSE 107

  Fly   306 LRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSA----NDRRAYHRYMTQV 366
            .:  .|:|.:...::.|.|..:..|:   |::.:  |..:.|..|..|    .:......|.|..
 Worm   108 CK--PSKPRLSSFFISAQDNRTIENV---DEVLF--PGFENYPCEEKAAIIIKEVGEIEDYTTTR 165

  Fly   367 ALLLGADPATAAAEL-EKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQ 430
            ::|:.|......::| ||:.:...:|.|             .::.::..|    :.:..|.:..:
 Worm   166 SVLVSAVNGFITSKLVEKLDVKARKLFN-------------KFKSVISKE----IIKTPWAKNYK 213

  Fly   431 AALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEF 495
            |       :::          |:..:..|...|                               |
 Worm   214 A-------IEQ----------YVEALSNITFRT-------------------------------F 230

  Fly   496 RKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAEND 560
            ..:.:.::.....:....:...|||.||         |:|.:.|:.
 Worm   231 ADVRITVKKSMELYESTEKDCRKKLDVA---------FSQPTAELV------------------- 267

  Fly   561 WMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRL 625
                 .:.||..||:         |||....|            |.|..:...||
 Worm   268 -----CKGVATRKAE---------ELLDEPIE------------DIFPQDQAGIL---------- 296

  Fly   626 LRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLN-------YGGIGVVIG 683
                  |:.|    .:.|:|.|              .::....|...||       ||.||..:.
 Worm   297 ------KDVW----QMFNSFDN--------------SVYIGNEFLLLLNTDYFSDLYGSIGFSMI 337

  Fly   684 HEITHG--FDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSR--------YKINEVDMFM 738
            |||.|.  |||  ...||..:.: |..||         .||.||..:        .:::.:....
 Worm   338 HEIMHTLVFDD--NDLDKPLSKL-WTKNA---------DCVKDQALKTCETFPTVTEMHNMKPAC 390

  Fly   739 DGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLN-MTHDQLFFLNYAQIWCGSMRPEDA 802
            :..:|..|:.||....:.|:|.|   |..:.|:..:|... :...||||...|..:|.    :|.
 Worm   391 NTTVTFEEDAADLAAYRIAWRIY---ENSYARKTVVPNYEALDKKQLFFYGAAVFFCN----QDG 448

  Fly   803 LTKI--RSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTM--NPAEKCSVW 849
            ::::  ::..||..:.||...:|..:.|:.|:||.....|  |.|:.|.::
 Worm   449 MSRVPFQNLAHSNNYQRVNSLMSQMKQFSDAFKCKPTDKMITNRAKHCELY 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	124/679 (18%)
nep-25	NP_495164.2	Peptidase_M13	308..496	CDD:279739	53/220 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910