DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and ECE1

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	758	Identity:	284/758 - (37%)
Similarity:	444/758 - (58%)	Gaps:	56/758 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 WLLKESQQRRRLLVLAIAFTV-LGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSA 165
            |..: :|..:||:||.:.... |.|.:.||.|.:.:
Human    67 WAAR-TQVEKRLVVLVVLLAAGLVACLAALGIQYQT----------------------------- 101

  Fly   166 HEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQ 230
              ...::|:::.||...:|:||:||...|||.|||.||||.|.|.:|:|:..|...||..|.:..
Human   102 --RSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHN 164

  Fly   231 QVILRAVLEE---PIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWS 292
            |.|::.:||.   .:.|.:.||.:    ::::||:..:|.::....|.::::.||||.:.    .
Human   165 QAIIKHLLENSTASVSEAERKAQV----YYRACMNETRIEELRAKPLMELIERLGGWNIT----G 221

  Fly   293 PPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDR- 356
            |.|..:.:..:..:..:|.......:||.||.|||:.|::|:||....||||||||.::. |::
Human   222 PWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTE-NEKV 285

  Fly   357 -RAYHRYMTQVALLL-GADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQEL 419
             ..|..||.|:..|| |.|......::::::.|||.|.|:::|:..|.|..|:|.|:...|||.|
Human   286 LTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTL 350

  Fly   420 VPEVQWQEYLQAALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHM 484
            .|.:.|..:|.....| :.:.|.||:|.|...||.::..::..|||.:::|||:|.||....|.:
Human   351 APAINWLPFLNTIFYP-VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFL 414

  Fly   485 IDEYQRERVEFRKILMGIQSERT---RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIH 546
            ...:|....:|.:::.|  :::|   ||..||..|...||.|:|.:|::..|.::||.:|.|:|.
Human   415 DQRFQDADEKFMEVMYG--TKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIIL 477

  Fly   547 TIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNV 611
            .|:.||.|.|:...|||:|||..||||||::...||||..:.:..||::.:.:.|.|||.:..|.
Human   478 EIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENA 542

  Fly   612 LSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYG 676
            :....:........||:..::::|:..|.:|||:|:|.||:|||||||||..||::..||:||:|
Human   543 MRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFG 607

  Fly   677 GIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGR 741
            |||||:|||:||.|||:||::||:||:..||.|:::|||:.:|:|:::|||.|.:|...  ::||
Human   608 GIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP--VNGR 670

  Fly   742 MTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKI 806
            .|.|||||||||||.|:|||:.|...:|.|..||.|.:|::|||||.:||:||....||.:...:
Human   671 HTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGL 735

  Fly   807 RSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            .:..|||...||:|.||||::|:..::||.||.|||..||.||
Human   736 ITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	262/661 (40%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	263/668 (39%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	262/662 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.830