Protein Alignment Nep1 and ECE1

DIOPT Version :10

• Sequence 1: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 1259
• Identity: 244/1259 - (19%)
• Similarity: 409/1259 - (32%)
• Gaps: 433/1259 - (34%)

  Fly    26 ECTCDKKGLVVDCSSSGLTRIPKNISRNVRSLVIRNNRIHKLKRSDLEGFNQLETLVLTHNKIKI 90
            ||...:.|.|...||:     .|...:...:.|:....:..:.|.:| |...|..|||....:.:
Human    69 ECLMFESGAVAVLSSA-----EKEAIKGTYAKVLDAYGLLGVLRLNL-GDTMLHYLVLVTGCMSV 127

  Fly    91 --IEENVLDHLPELKRLSLAHNELVYIPPLCSDSRPLASLNLKRNHIQFIDEQVLRYF---PDLT 150
              |:|:.:..:...:.:||..:        .||...::.:....|...|       ||   ....
Human   128 GKIQESEVFRVTSTEFISLRVD--------ASDEDRISEVRKVLNSGNF-------YFAWSASGV 177

  Fly   151 QLDFSHNRIQSLRTKLFDNL----PALSHAHLHSNPWHCDCRASKVKALLQKVKWEKKVYCTNPV 211
            .||.|.|..:|::....||.    .:| |.||.....:||             .|..::.| ..|
Human   178 SLDLSLNAHRSMQEHTTDNRFFWNQSL-HLHLKHYGVNCD-------------DWLLRLMC-GGV 227

  Fly   212 ELR-----HQALDEVDDSALTCARPAEESWTGEEIKLT-----CAKNSSSKLVVWMYENVEVDSS 266
            |:|     |:.......|.|:|    |.:.|...::.|     .|....::.|:::.:.|   ||
Human   228 EIRTIYAAHKQAKACLISRLSC----ERAGTRFNVRGTNDDGHVANFVETEQVIYLDDCV---SS 285

  Fly   267 SLDGYEIHDTVITVPRKTNVNFMTCTYDFDHIPHHRRLRQSQHQGNGSPQFTYKPRDNSFRE--- 328
            .:   :|..:|.....:..:          .:..| |:|.|:.....:|.|     |..||.
Human   286 FI---QIRGSVPLFWEQPGL----------QVGSH-RVRMSRGFEANAPAF-----DRHFRTLKD 331

  Fly   329 --GSEVKVNCEVMGNPKPTINWYHNGKRFISSRKRQLGLS---------------------NNVL 370
              |.::.||  ::|:.:   ..:...|.|.|..|.....|                     ::||
Human   332 LYGKQIVVN--LLGSKE---GEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSVL 391

  Fly   371 R--IYPFLEE-------------DSG--RYTC-EAVNSVGKVRHAFSLDLISS--VPPNIYEGPQ 415
            :  :..||:.             .||  |..| :.::....|:....|::::.  ....:.|.||
Human   392 KPQVQKFLDYGFFYFDGSAVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQ 456

  Fly   416 SVS--QNLGGSVVFVCKANGNPVPDYTWSFDGSTI-------GHIKGRFMVS--DDGTELRISNI 469
            .|:  |.:..|:               ||.:|.:|       |.::|:....  .||.......|
Human   457 LVTRFQEVFRSM---------------WSVNGDSISKIYAGTGALEGKAKAGKLKDGARSVTRTI 506

  Fly   470 E------KKDEGYYSCMAGNPVGAMSAD-AKLTVIGGETRKAAAPQIDEEL-------------- 513
            :      .|.|.....:.||.:.:..|| |:..:..|..|  |:.::.:.:
Human   507 QNNFFDSSKQEAIDVLLLGNTLNSDLADKARALLTTGSLR--ASSKVLKNMCENFYKYSKPKKIR 569

  Fly   514 -------------LRAIAQKARQNVE---NAVEKTRKQLTQDKVTNTNDL-------------KR 549
                         .|:||.|.:...:   :|.:....|..|||.:...|:             ..
Human   570 VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGN 634

  Fly   550 LFRFSTPKQ---AVELSKAREIYEESVRLVREHVEKGLILNVDELHPKNVSYESVLHVTHVQALM 611
            :...||..|   ||||.|......:.|.|..|.: .|:.|.| .:.|::..:...:.|..|:.
Human   635 IVNASTTNQKLWAVELQKTISRDNKYVLLASEQL-VGVCLFV-FIRPQHAPFIRDVAVDTVKT-- 695

  Fly   612 GLSGC-------------HTGQYKNPCTDTCF--HHRYRSFDGQCNNKNKPMTGVSLMPLRRLLK 661
            |:.|.             ||       |..||  .| :.:...|...:|:....::    |:|..
Human   696 GMGGATGNKGAVAIRMLFHT-------TSLCFVCSH-FAAGQSQVKERNEDFVEIA----RKLSF 748

  Fly   662 PVYENGFNTPVGWEKGRLYNGYPLPN--VREVSRQ-----LVATENITPHSKLSSMVMQWGQFVD 719
            |:....|:....:..|.......|||  |:|:.||     |:|.:.:. :.|.:..:.:  .|::
Human   749 PMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLI-NQKNAGQIFR--GFLE 810

  Fly   720 HDLTHTVT---ALSRHSYATGAFCNRTCENLDPCFNIPLSPNDPRVKSGSAKYPCIEFERSAAVC 781
            ..:|...|   .|....|.|...| ||     |.:.       .||.....|:|   |:|||
Human   811 GKVTFAPTYKYDLFSEDYDTSEKC-RT-----PAWT-------DRVLWRRRKWP---FDRSA--- 856

  Fly   782 GSGETSLVFNRVTYREQMNAL-TSFLDASNV-----------YGSNEVQAQELRDTYNNNGMLRF 834
                           |.::.| .||.|.|.:           ||..|::..:.|...   .::..
Human   857 ---------------EDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVV---ALIDI 903

  Fly   835 DITSEAGKEYLPFEKDSNMDCRRNFSEENPIRCFLAGDLRANEQLALAATHTIFIREHNRIAKKL 899
            ||          ||.::                                      .|..:|.|::
Human   904 DI----------FEVEA--------------------------------------EERQKIYKEV 920

  Fly   900 KSMNGNWDGEIIYHETRKIVGAMMQHITYKHWMPIIFGGQAQMNKFVGTYQGYDPDVDASVTNAF 964
            .::.|..||.::                      :.....||.|.|      :|..:...:...|
Human   921 IAVQGPPDGTVL----------------------VSIKSSAQENTF------FDDALIDELLQQF 957

  Fly   965 ATAAFRFGHTIINPSLFRLGNDFMPIK--EGHIALHKAFFTPELVLTQGGVDPLLRGLFASPLKH 1027
            |    .||..|    |.|...|.|.:.  ||..||:        ||:..|.: ||.......||.
Human   958 A----HFGEVI----LIRFVEDKMWVTFLEGSSALN--------VLSLNGKE-LLNRTITITLKS 1005

  Fly  1028 PMPTQLLNMEL-IEK------------LFMKGHEVSLD----------------LAVMNIQRSRD 1063
            |...:.|..|: :||            |..:..|||.|                |...::|.|..
Human  1006 PDWIKTLEEEMSLEKISVTLPSSTSSTLLGEDAEVSADFDMEGDVDDYSAEVEELLPQHLQPSSS 1070

  Fly  1064 HGL---PSYTEYRKFCNLPVPVQW 1084
            .||   ||.:.....|..|...::
Human  1071 SGLGTSPSSSPRTSPCQSPTAPEY 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_511056.2	M13	194..847	CDD:341056	154/809 (19%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	140/742 (19%)