Protein Alignment Nep1 and Phex

DIOPT Version :10

• Sequence 1: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Alignment Length: 711
• Identity: 253/711 - (35%)
• Similarity: 409/711 - (57%)
• Gaps: 37/711 - (5%)

  Fly   167 EGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQ 231
            :.:...|:..||:..||:::|.::|:.||||:||::||..|...:|||||..|...:..|.....
Mouse    48 QAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVD 112

  Fly   232 VILRAVLEEPID-ERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQ-SLGGWPVIERNWSPP 294
            :.|:|:||:.:. .||.:|..|||..:.|||:...|.|.....|..:|: |...|||:|.|..|.
Mouse   113 LKLKALLEKSVSRRRDTEAVQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIGPE 177

  Fly   295 A-----DLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKES--S 352
            .     ..|:.:.:...|..||..|.|.|||..|||.|:.:||::||...:|..|:.:|..:  :
Mouse   178 GVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEA 242

  Fly   353 ANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQ 417
            .:.|.|.:::|...|:||||:.:.|..:::.|:..|.::..:.:|..:| .:..:|.||.:.||.
Mouse   243 KSYRDALYKFMVDTAVLLGANSSRAEHDMKSVLRLEIKIAEIMIPHENR-TSEAMYNKMNISELS 306

  Fly   418 ELVPEVQWQEYLQAA-----------LGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNY 471
            .::|:..|..|::..           :||      .|.:|.....|..::.:||....::.:.||
Mouse   307 AMIPQFDWLGYIKKVIDTRLYPHLKDIGP------SENVVVRVPQYFKDLFRILGAERKKTIANY 365

  Fly   472 MLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQE 536
            ::||:|.|.:.::...:|...:||.:::.|..:...:|.:||.:....|...||.:|:..:|.::
Mouse   366 LVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQED 430

  Fly   537 SKEVALEMIHTIRAAFNELL-AENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNL 600
            .||:..|:|..:|.||.::| .||:|||..|:..|:|||.::..::||||.:.|.|.:.::...:
Mouse   431 KKEMMEELIEGVRWAFIDMLEKENEWMDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAI 495

  Fly   601 TIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQ-PLF 664
            .....::..|||...::.::.....||:.|.|.:|.|.|..|||||:.:.|.|.||||.|| |.|
Mouse   496 KFSESDYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFF 560

  Fly   665 YSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRY 729
            :...:|:||:||.|||::|||.|||||:.||::||.||:..||:..:.|.|:|:|:|:|:|||.|
Mouse   561 WGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNY 625

  Fly   730 KINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQ-----QLPGLNMTHDQLFFLNY 789
            ...:..:.:.|:.|.||||||||||::|||||:||  ::.|.|     .|||:..|::|||||:|
Mouse   626 YWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKW--INDRRQGVEEPLLPGITFTNNQLFFLSY 688

  Fly   790 AQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMN-PAEKCSVW 849
            |.:.|.|.|||.|..:::...|||...||.|.:||..:|..|:.||..|||| .|:.|.:|
Mouse   689 AHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPRNSTMNRGADSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_511056.2	M13	194..847	CDD:341056	244/680 (36%)
Phex	NP_035207.1	M13	74..740	CDD:341056	241/674 (36%)