DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and nep-17

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	752	Identity:	210/752 - (27%)
Similarity:	332/752 - (44%)	Gaps:	135/752 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 AMDLNS--DPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDE---RDN 247
            |..:|:  |||:||:.||||.:|:         |:| |.....|..|.:...||:|..:   ..:
Worm   877 AKSVNTAIDPCDDFYSYACGNFNQ---------SVS-FYTARAQNLVYMAQKLEDPTYQTTINSS 931

  Fly   248 KATIKAKTFFKSCMDIPQIRK------IGTGRLKQVLQSL------------GGWPVIERNWSPP 294
            .|..|.|..:.:|:......:      |....::..:..|            ||.|.:      |
Worm   932 PALKKEKQLYNACLTATASSQSEDQILISKNYIQTKVDDLKTLIGQDFTLVNGGAPKL------P 990

  Fly   295 ADLSVERLMGQLRLNYSEPVMIELYVGA---DDKNSSVNILQMDQLQYALPSRDYYLKESSANDR 356
            :...:...:|.|........:|...|..   |  ||....:.:|| ..|..|:.||...:...::
Worm   991 SAKQIGDALGYLSFEQGIDTLISPLVDTYWID--NSKGYQMFIDQ-NTAYLSKTYYQPAAWKIEK 1052

  Fly   357 RAY--------HRYMTQVALLLGADPATAAAELEKVVLFETQL-VNVSLPEADRHDTSLVYRKML 412
            ..|        .||..:..:.|   ||.|:..|..|:.:|..: |..|..:..|..   ..|...
Worm  1053 PKYLKMALDVVTRYAREQNITL---PAGASDLLSNVLDYEQNIAVKYSTDDNTRRQ---FQRSWN 1111

  Fly   413 LPELQELVPE---VQWQEYLQAALGPG------------IPLQEDEPLVTYGLHYLTEMGKILAH 462
            |.:..:||.:   :.|..||..|  |.            :.:.|.:.|..:...||.:..::|.
Worm  1112 LTKTSDLVTKYNFMDWMTYLSHA--PNAVKAKITDANYQVSVMEVDRLTHFSADYLQQSPELLV- 1173

  Fly   463 TDRRVVHNYMLWRLVM----------SLMSHMIDEYQRERVEFRKILMGIQSERT---------- 507
                   |.:..||::          |....|.||         .|.:|:...:|
Worm  1174 -------NLLFVRLLLGNAQYIPSYASAFRGMTDE---------SIFLGLSRRKTIPNHIPPPNF 1222

  Fly   508 ----RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEV------ALEMIHTIRAAFNELLAENDWM 562
                ....|....|..:..|.|.:|: |.....:::|      |..:|..:.::|..::.:.|||
Worm  1223 DLEANGPACASVANNLMQFANGRVFV-DYMYPTAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWM 1286

  Fly   563 DDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIV-PDNFINNVLSILQWE-SEKMLRL 625
            ..:|:..|..|...:.:.|.:|:.:.|.|.|...|..|.|. .|||.:....::::. ..:..:|
Worm  1287 APDTKQKAYAKTVQIQQNIAFPDWIKNDTLLGNYYSTLVIADSDNFYDIYDKLIKFNIFVQYNQL 1351

  Fly   626 LRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGF 690
            .....|:..:..:|..|||:|.|..|.|.||||||.|.:::.::|.|:||||:|:|.|||:||||
Worm  1352 NAAQTDRTDFLGQPGTVNAWYQPELNSITFPAGILVPPYFNPNWPPSINYGGMGLVAGHELTHGF 1416

  Fly   691 DDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRY----KINEVDMFMDGRMTQGENIADN 751
            ||:|.|:...||:.:|.::.::..|:..:||||::||.:    ..|.....:.|..|||||||||
Worm  1417 DDQGVQWGPTGNLARWMDDNSMAGFKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGENIADN 1481

  Fly   752 GGLKQAFRAYKKWETLHGREQQLPGL---NMTHDQLFFLNYAQIWCGSMRPEDAL-TKIRSAVHS 812
            ||:..||.|||..::|.|.:.:||..   ..|||||||:::||:||...|.:||| |:|....||
Worm  1482 GGVHAAFNAYKTHQSLDGPDPRLPDRLFGQFTHDQLFFMSFAQVWCEVRRTDDALYTQIMVDPHS 1546

  Fly   813 PGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            |...||.|.:.|...|.:|:.|||||...|.:.|.||
Worm  1547 PSMYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVW 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	205/740 (28%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118
		M13	112..830	CDD:189000
		PepO	880..1583	CDD:226118	207/747 (28%)
		M13	884..1581	CDD:189000	205/741 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020