Protein Alignment Nep1 and nep-17

DIOPT Version :10

• Sequence 1: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_001254395.1
• Gene: nep-17 / 174996
• WormBaseID: WBGene00010070
• Length: 1589
• Species: Caenorhabditis elegans
• Alignment Length: 752
• Identity: 210/752 - (27%)
• Similarity: 332/752 - (44%)
• Gaps: 135/752 - (17%)

  Fly   188 AMDLNS--DPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDE---RDN 247
            |..:|:  |||:||:.||||.:|:         |:| |.....|..|.:...||:|..:   ..:
 Worm   877 AKSVNTAIDPCDDFYSYACGNFNQ---------SVS-FYTARAQNLVYMAQKLEDPTYQTTINSS 931

  Fly   248 KATIKAKTFFKSCMDIPQIRK------IGTGRLKQVLQSL------------GGWPVIERNWSPP 294
            .|..|.|..:.:|:......:      |....::..:..|            ||.|.:      |
 Worm   932 PALKKEKQLYNACLTATASSQSEDQILISKNYIQTKVDDLKTLIGQDFTLVNGGAPKL------P 990

  Fly   295 ADLSVERLMGQLRLNYSEPVMIELYVGA---DDKNSSVNILQMDQLQYALPSRDYYLKESSANDR 356
            :...:...:|.|........:|...|..   |  ||....:.:|| ..|..|:.||...:...::
 Worm   991 SAKQIGDALGYLSFEQGIDTLISPLVDTYWID--NSKGYQMFIDQ-NTAYLSKTYYQPAAWKIEK 1052

  Fly   357 RAY--------HRYMTQVALLLGADPATAAAELEKVVLFETQL-VNVSLPEADRHDTSLVYRKML 412
            ..|        .||..:..:.|   ||.|:..|..|:.:|..: |..|..:..|..   ..|...
 Worm  1053 PKYLKMALDVVTRYAREQNITL---PAGASDLLSNVLDYEQNIAVKYSTDDNTRRQ---FQRSWN 1111

  Fly   413 LPELQELVPE---VQWQEYLQAALGPG------------IPLQEDEPLVTYGLHYLTEMGKILAH 462
            |.:..:||.:   :.|..||..|  |.            :.:.|.:.|..:...||.:..::|.
 Worm  1112 LTKTSDLVTKYNFMDWMTYLSHA--PNAVKAKITDANYQVSVMEVDRLTHFSADYLQQSPELLV- 1173

  Fly   463 TDRRVVHNYMLWRLVM----------SLMSHMIDEYQRERVEFRKILMGIQSERT---------- 507
                   |.:..||::          |....|.||         .|.:|:...:|
 Worm  1174 -------NLLFVRLLLGNAQYIPSYASAFRGMTDE---------SIFLGLSRRKTIPNHIPPPNF 1222

  Fly   508 ----RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEV------ALEMIHTIRAAFNELLAENDWM 562
                ....|....|..:..|.|.:|: |.....:::|      |..:|..:.::|..::.:.|||
 Worm  1223 DLEANGPACASVANNLMQFANGRVFV-DYMYPTAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWM 1286

  Fly   563 DDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIV-PDNFINNVLSILQWE-SEKMLRL 625
            ..:|:..|..|...:.:.|.:|:.:.|.|.|...|..|.|. .|||.:....::::. ..:..:|
 Worm  1287 APDTKQKAYAKTVQIQQNIAFPDWIKNDTLLGNYYSTLVIADSDNFYDIYDKLIKFNIFVQYNQL 1351

  Fly   626 LRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGF 690
            .....|:..:..:|..|||:|.|..|.|.||||||.|.:::.::|.|:||||:|:|.|||:||||
 Worm  1352 NAAQTDRTDFLGQPGTVNAWYQPELNSITFPAGILVPPYFNPNWPPSINYGGMGLVAGHELTHGF 1416

  Fly   691 DDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRY----KINEVDMFMDGRMTQGENIADN 751
            ||:|.|:...||:.:|.::.::..|:..:||||::||.:    ..|.....:.|..|||||||||
 Worm  1417 DDQGVQWGPTGNLARWMDDNSMAGFKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGENIADN 1481

  Fly   752 GGLKQAFRAYKKWETLHGREQQLPGL---NMTHDQLFFLNYAQIWCGSMRPEDAL-TKIRSAVHS 812
            ||:..||.|||..::|.|.:.:||..   ..|||||||:::||:||...|.:||| |:|....||
 Worm  1482 GGVHAAFNAYKTHQSLDGPDPRLPDRLFGQFTHDQLFFMSFAQVWCEVRRTDDALYTQIMVDPHS 1546

  Fly   813 PGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            |...||.|.:.|...|.:|:.|||||...|.:.|.||
 Worm  1547 PSMYRVYGTIQNFPAFQTAFNCPLGSKSAPEQHCEVW 1583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_511056.2	M13	194..847	CDD:341056	205/740 (28%)
nep-17	NP_001254395.1	M13	112..831	CDD:341056
		M13	884..1581	CDD:341056	205/741 (28%)