Protein Alignment Nep1 and nep-26

DIOPT Version :10

• Sequence 1: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_001022540.1
• Gene: nep-26 / 174593
• WormBaseID: WBGene00014171
• Length: 807
• Species: Caenorhabditis elegans
• Alignment Length: 873
• Identity: 225/873 - (25%)
• Similarity: 384/873 - (43%)
• Gaps: 136/873 - (15%)

  Fly    42 QQVQHQAPHQMQQQQQQQQQNKLPTVVFLAPDGSGGVGIQRGNPAQGNPGMVTGTGSHSDWLLKE 106
            :::|....|:|:.......  .||:........|.||.::.|.  |.:..::..||..|....||
 Worm     6 EKLQRSLSHEMRSYSSLNP--LLPSEDTPIQSFSNGVSLEEGK--QASSSLLRDTGQPSSSRSKE 66

  Fly   107 --SQQRRRLLVLAI----AFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSA 165
              |...:..|:|.:    .|..|..||.            |.||.
 Worm    67 AISSSSKGCLLLTVLVIFLFVTLSFAIA------------CFLYY-------------------- 99

  Fly   166 HEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTW-NKMHPIPED--RSSISTFEVLS 227
               |...|.::|||.||:.||..:|.:.:||::|:|:|||.| |:...:..|  .:...|.....
 Worm   100 ---QTLPCTSEECVMTASRLLKRVDQSVEPCDNFYQFACGGWINQSVNLKYDSWNTLYETQRTAH 161

  Fly   228 DQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWS 292
            ||....:..:.:.......|.....|...::.|||...:.:.|....::.:..||||....:|.:
 Worm   162 DQIVQAMHKINDGSYPLPTNAGERAAAKMYEQCMDTDTLEQTGLHLWERFVDELGGWMPELKNGA 226

  Fly   293 PPADLSVERLMGQ---------------LRLNYSEPVMIELYVGADDKNSSVNILQM-DQLQYAL 341
            ...:.|.|..:.:               ...|||...:....|..:..||..:::.: :||...|
 Worm   227 LEQEESFEIELDEDEKKRRRFEIEDIILSAFNYSVFPLFWAGVEVNYLNSKEHLITIYEQLPILL 291

  Fly   342 -PSRDYYLKESSAN----------DRRAYHRYMTQVALLLGADPATAAAE--LEKVVLFETQLVN 393
             |.:.:|.||.:..          ..||..:...:::.:||.|.......  :..::..|.|:..
 Worm   292 APEKYHYNKELTPEMIYGKMEGPPVTRALQQVGEELSAVLGFDSTDEKVRMMIANMIYLEYQITM 356

  Fly   394 VSLPEADRHDTSLVYRK-------MLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPL-VTYGL 450
            ..         |..|::       ::|.||||:.|.:.|..:|...:|..  |...||: :..|.
 Worm   357 AG---------STFYKEKKERYTVVMLRELQEIAPAINWHYFLSRLVGEN--LSHSEPIALKTGT 410

  Fly   451 HYLTEMGKIL-----AHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILM--GIQSERTR 508
            .::..:..|:     :.:...|:.||:.|:.:|..:::...:. |:.:.:..:.:  |..|:|..
 Worm   411 QWIPILSAIVEKLKQSRSGVAVLKNYVKWKTIMFHLAYASPKC-RDGLLWMAVSLYSGAASQRKE 474

  Fly   509 WSQCVEWTNKKLGVAVGALFIR-DNFNQESKEV-ALEMI-HTIRAAFNELL-AENDWMDDETRAV 569
            :  ||...:....:::.::..: |..:...|.| |::.| ..|:..:.|:: :.|.:.|.|||..
 Worm   475 F--CVLRLSGIFPLSLPSILRKIDGIDHTEKNVKAVQNIADRIQEKYEEMVRSSNLFSDRETREN 537

  Fly   570 AKEKADSMNERIGYPELLTNATELEQEYVNL--TIVPDNFINNVLSILQWESEKMLRLLRQPVDK 632
            ..:|.::|.:.||:|:.:.:..|:|:|.|.|  |:    |.:.||.......|::.| ||.|||.
 Worm   538 VIDKVNNMTKFIGFPDAMRSDYEMEKEAVRLHDTL----FWSMVLGSSSVYKERLQR-LRLPVDP 597

  Fly   633 EKWT-TEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQ 696
            ..|. |.||:....:|..:|.:..|...|:..:..:|.....||.|||.:||||:||.||.:|:.
 Worm   598 RSWVDTRPAISVPAHNYERNLVQIPFDSLRLPYADEHQLDFANYAGIGTIIGHELTHAFDGQGKL 662

  Fly   697 FDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQG--ENIADNGGLKQAFR 759
            ....||:..||:..:|..|:.|.||.:.||:.. ::..||   ....:|  |||||..|||.|:.
 Worm   663 HGPTGNLGVWWSTDSIREFKAREQCFVKQYAGL-MDSHDM---NAAKEGLYENIADQVGLKVAYE 723

  Fly   760 AYKKWETLHGREQ--QLPGL-NMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGP 821
            |:|.    :|.:.  ::||| ..:.||||||.|.|.|| ::|.:    ..:...|....:|:||.
 Worm   724 AWKS----NGNQNSGRMPGLEKYSQDQLFFLAYTQGWC-ALRSK----SYKLQPHMEERIRMLGS 779

  Fly   822 LSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            |.||.:||||:||...|.|||.:|||:|
 Worm   780 LQNSPEFASAWKCSSESFMNPPDKCSIW 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_511056.2	M13	194..847	CDD:341056	187/711 (26%)
nep-26	NP_001022540.1	M13	124..805	CDD:341056	187/712 (26%)