Protein Alignment Nep1 and nep-5

DIOPT Version :10

• Sequence 1: NP_511056.2
• Gene: Nep1 / 31547
• FlyBaseID: FBgn0029843
• Length: 849
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 791
• Identity: 175/791 - (22%)
• Similarity: 297/791 - (37%)
• Gaps: 217/791 - (27%)

  Fly   115 VLAIAFT-----VLGAAIGALAIYFASVHQRCHLYRLEPDND-------DRPNGRWNQDSGSAHE 167
            |||:..|     :|..|:|||.::..|.      ::.||...       |.|
 Worm    62 VLAVITTLVILVLLIFALGALGLHDISA------FKWEPKPQKALRIMLDLP------------- 107

  Fly   168 GQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQV 232
                 |.|:|||:.:|.||..||.:.:|||:|..:.|   |..:|..:|      ||.|     :
 Worm   108 -----CQTKECVKYSAELLELMDSSVNPCENFHHHVC---NGFNPRKKD------FERL-----M 153

  Fly   233 ILRAVLEEPIDERDNKATIKAKTFFKSCM-----DIPQIRKIGTGRLKQVLQSLGGWPVIERNWS 292
            .|..:.|:| |.|  ||....:.....|.     :|.|:     |||..::.....:|::..:|:
 Worm   154 KLINIQEKP-DHR--KAVNVVRRMLSKCAMGKTEEIHQV-----GRLSSIILPGLPFPLLNNSWT 210

  Fly   293 PPAD-LSVERLMGQLRLNYSEP----VMIELYVGADDKNSSVNILQMDQLQYAL----------- 341
            .|:| :|.    ......||.|    ::..:.:...|....|.|......:::|
 Worm   211 KPSDPIST----SNSSTTYSYPFLTKILAHIILHNPDDAGFVGIKPSSDSEFSLFVVKPFSPVLT 271

  Fly   342 --PSRDYY--LK----ESSAN-------DRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQL 391
              ..|:.|  ||    |||.|       ||:                     .:|..|:..:|:|
 Worm   272 NFKFRNMYDILKRNAPESSTNGMIDLEFDRQ---------------------RQLNDVIKLQTKL 315

  Fly   392 VNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLH--YLT 454
            ..:..    :.|..:|.    |.|:|..:|.:.|:..:.:.:..|....:::   .||.:  |..
 Worm   316 EKIEF----KADPEVVN----LTEIQRQMPIIDWKRLIDSWIPNGYAHLKEK---VYGFNTSYYE 369

  Fly   455 EMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKK 519
            |:..|::.|....::|::..|.....:          |.|....|     |.|    |:.    :
 Worm   370 EINAIISSTPSETIYNFLFLRFSFKFL----------RTEVASDL-----EDT----CLH----Q 411

  Fly   520 LGVAV-GALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGY 583
            |...: |.:.:..:...|:..:...|:|||:......||...|||......|::|.:......|:
 Worm   412 LSTTIPGKIVLYGSEEPEALNLLNGMLHTIKDQLKRSLATLKWMDSRGIEEAQKKFNKTKTVFGF 476

  Fly   584 PELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNA--FY 646
                 ...:|..|.|.......|:|:.:.::|.|::..|.:.:.:       ......:|:  ||
 Worm   477 -----TGEDLIDELVGKITPESNYISTLQNVLLWQTRNMFKSVAE-------NNVTVFLNSEVFY 529

  Fly   647 NPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNAT 711
            :..||:|.....:|...|.|.:.|...|:..|...|..::.|.||::||.:|.:||...|||..|
 Worm   530 SVEKNEITISRALLHYPFMSANLPNYTNFATIASKILPQMIHIFDERGRFYDSDGNHRNWWNTET 594

  Fly   712 IEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQ---Q 773
            ...|:...||                .||.|.....::.:.|          |......::   .
 Worm   595 ERYFQIIVQC----------------FDGMMQNVFGVSVSIG----------WNAYDSTKEPYAT 633

  Fly   774 LPGLNMTHDQ-LFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLG 837
            |||:..:.|: |||.:..:..|.| .|::                |...|::...|.||:||..|
 Worm   634 LPGIQQSSDEALFFYSMVKTMCTS-DPDN----------------VNEALASVPQFNSAFKCNNG 681

  Fly   838 STMNPAEKCSV 848
            :.|||..||.:
 Worm   682 TKMNPPTKCKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_511056.2	M13	194..847	CDD:341056	150/697 (22%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:472708	150/698 (21%)