DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and nep-11

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_494538.1	Gene:	nep-11 / 173685	WormBaseID:	WBGene00017557	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	830	Identity:	284/830 - (34%)
Similarity:	468/830 - (56%)	Gaps:	67/830 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 QNKLPTVVFLAPDGSGGVGIQRGNPAQGNPGMVTGTGSHSDWLLKESQQRRRLLVLAIAFTVLGA 125
            :::.|:|:|:.           |...||.          ..|....:...:.||.:.:.|.:|.|
Worm    45 RDEAPSVIFIP-----------GKKFQGT----------FRWWKSRTTMEKLLLPVLLLFCLLTA 88

  Fly   126 AIGALAIYFASVHQRCHLY---------------------------RLEPDNDDRPNGRWNQDSG 163
            .:.|:.|   :..:|....                           |:.|...:.|.....:.:.
Worm    89 VLLAVII---NTDKRIEAMKTDHATQTEHAGFGDPTENPTKTAEDPRVPPIVPEAPTSPEPEVTT 150

  Fly   164 SAHEGQD-NICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLS 227
            |..:.:: .:|.|..|||.|...|:||:.:.|||:|||::|||.||..||||:|.....||....
Worm   151 STEKPKEPEVCSTPGCVRAATHFLNAMNTSVDPCDDFFEFACGQWNDQHPIPDDMYGFGTFAYAR 215

  Fly   228 DQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWS 292
            :|.:..||.:||:.: ..::::...|:..::|||:..|:.::.||.|.:.|..||.||:::.||.
Worm   216 EQVRQQLRVLLEQEV-VTESESINMARATYRSCMNKTQLDELMTGPLFETLTELGEWPLLQENWD 279

  Fly   293 PPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYAL--PSRDYYLKES-SAN 354
             ....:...|:...|.:|...|..:||:.||.||:|.|.|.:||...||  .:|||||..: .::
Worm   280 -KTKFNFTSLLVNSRRDYGVDVFFQLYIYADSKNTSRNTLFIDQSTLALGRGTRDYYLNTTLFSS 343

  Fly   355 DRRAYHRYMTQVALLLGAD------PATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLL 413
            ...||.:|:.|:|.||..|      .:...|::||::.||.:|..:.:.|.:|.:.:.:|.|..:
Worm   344 HMTAYRKYLRQIAHLLKTDGNLTRSESEMNADIEKIIDFEIELAKIIVAEDERRNNTRLYNKRQI 408

  Fly   414 PELQELVPEVQWQEYLQAALGPGIP--LQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRL 476
            .:|..|:|:|.|..:.|:.....:.  ...:..::...:.||..:.:::..||..::.||:|||:
Worm   409 QDLYNLLPQVDWVPFFQSIAPSDLTHLFHNETEIIICEIEYLQHVSELIEKTDVGLLTNYVLWRV 473

  Fly   477 VMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVA 541
            |.|.:.::.:.::..:.:|.|::.|.|....||..|.:..:..|.:|.||::::.:|.:..|..|
Worm   474 VQSNVRYLDERFEDIKQDFLKVMTGQQQSPPRWKDCAQVPSTVLPLAAGAIYVQAHFQESDKHEA 538

  Fly   542 LEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIV-PD 605
            |.||..:|.:|.:|:.:|||||:||:|||.|||:||...||||::..:..:|:::|:.|:|. .|
Worm   539 LRMIMHLRNSFADLVRQNDWMDEETKAVAIEKANSMINNIGYPDVTNDLPKLDKQYLGLSISDSD 603

  Fly   606 NFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFP 670
            .:...:...:.|...:..:.|.:|.||.::...||||||||:|.||.|.||||||||.|:|..||
Worm   604 TYYYIMKKSVVWMQSREFQKLTKPFDKHEFDISPAVVNAFYSPEKNAITFPAGILQPPFFSGTFP 668

  Fly   671 KSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVD 735
            |::|||.||.||||||||||||:|.|:||:||:..||:.:::.:|..|.:|:::||..|.:.:.:
Worm   669 KAVNYGAIGAVIGHEITHGFDDQGSQYDKDGNLHNWWSESSLNSFDTRRRCIVEQYGNYTVPKTN 733

  Fly   736 MFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNM-THDQLFFLNYAQIWCGSMRP 799
            ..::|::|||||||||||:|:||:||:|:.|.:|.|.:||||.. |::|:||::||..|||..:.
Worm   734 FRVNGKLTQGENIADNGGVKEAFQAYQKYVTENGEEPRLPGLQQYTNEQIFFVSYAHFWCGKKKE 798

  Fly   800 EDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            ..|:.::.:..|||...||:|.|||.:.||..||||..:.:||..||.||
Worm   799 AAAMQQVLTDEHSPEVFRVIGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	253/665 (38%)
nep-11	NP_494538.1	PepO	174..848	CDD:226118	257/675 (38%)
nep-11	NP_494538.1	M13	181..845	CDD:189000	252/665 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56679
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D157132at33208
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	LDO	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860