DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and nep-10

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_494532.2	Gene:	nep-10 / 173684	WormBaseID:	WBGene00017555	Length:	711	Species:	Caenorhabditis elegans

Alignment Length:	785	Identity:	181/785 - (23%)
Similarity:	333/785 - (42%)	Gaps:	143/785 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQ-----DSGSAHEGQD-NI 172
            |:|.|.|..|......:.|..|.|.:         .:|..|.|..:|     ||.:....:. |:
Worm    21 LLLLIVFLALVTVHIKMTIDVAPVFK---------SDDPLPRGDPDQKPATIDSETQTVDEPRNV 76

  Fly   173 CMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAV 237
            |.:.||:..|..|.:..|.:.|||:||:|:.||.:.:...|.:.|.:..             |:.
Worm    77 CESPECITLAHELHNYKDPSVDPCQDFYQHFCGKFYEHSAIGQGRMATK-------------RST 128

  Fly   238 LEEPIDE---RDNKATIKA----KTFFKSCMDIPQIRKIGTGRLKQVL------QSLGGWPVIER 289
            |.:.|.|   ::..:|.|:    |..:..|.::.:|..:.:...:.:|      :.:|.|||:::
Worm   129 LSKLIREFLLKNKTSTSKSENTMKQVYAKCRELQKISDLNSIPPQALLDIFSDIKKIGAWPVLDK 193

  Fly   290 NWSPPADLSVERLMGQLRLNYSEP--------------VMIE--LYVGADDKNSSVNILQMDQLQ 338
            :|. .:..::..::.|| :|..|.              |:|:  |..|. .|:....:::|
Worm   194 DWD-GSKFNLNEMLRQL-VNLGETHLGFFHFDFIARPYVLIKPPLKQGV-QKSVLEKVVKM---- 251

  Fly   339 YALPSRDYYLKESSANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEADRHD 403
             .|.:.:..:.:..:.|...|.....::             :::|:......:|.: ||:..|
Worm   252 -ILEANEIKMDQGFSEDLDEYFELSNRI-------------KIDKLPRTSRSIVGL-LPDVRR-- 299

  Fly   404 TSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLHY--------LTEMGKIL 460
              :.:|.::|    |::|..:...:|      |...|:   :|||  |:        ...:..|:
Worm   300 --INFRGLIL----EMMPRSKMNRFL------GTLFQK---VVTY--HHPLFVRDNETNHLDTII 347

  Fly   461 AHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCV--EWTNKKLGVA 523
            ..|..|.:.||:::..:.|            .::|  :..|::|:|.|..:.|  |.....|.|
Worm   348 RSTSNRALANYLIFNFIHS------------SIKF--LTFGLKSDRERCEKIVVQELPRPSLRV- 397

  Fly   524 VGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPELLT 588
                |:|:..::.::|...::..|::....|::.|:|......:....:|.:::...||||:...
Worm   398 ----FMRNCVDKGNREEVAKLTETVKENVLEMIRESDSFTPSVKKRVLKKVEAIGAIIGYPDHFD 458

  Fly   589 NATELEQEYVNLTI-VPDNFINNVLSILQWESEKMLRLL--RQPVDKEKWTTEPAVVNAFYNPNK 650
            ....|::||.|||: ..|::......:.|...:..:..|  :.|:.......|   |||.|:...
Worm   459 PPGTLDKEYENLTLDASDSYYKMSQKLHQLRLQHQMEFLAGQTPLSPSDQVLE---VNAHYDSKD 520

  Fly   651 NDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAF 715
            |.:...|..|...|:...:|:.:|....|.:||||..|..|.|..:.|      .|:....:..:
Worm   521 NALTVLAPFLDDPFFDSTYPEYVNLIFTGFLIGHEFGHSIDPKILRRD------GWYKTEDMTEY 579

  Fly   716 RERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGL-NM 779
            .:|.||:||||..|...:....|:|....||.:.|..|....:||:||.:.  .:.|:|.|. :.
Worm   580 GKRAQCLIDQYDNYDDPDHGKQMNGTYCIGEIVGDWVGRDVTWRAFKKMDL--SKMQKLIGFEDK 642

  Fly   780 THDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAE 844
            ..|||:|...:..:||. |...:|.::.|..|.....||.|..||...||.|:.||:||.|||.:
Worm   643 NLDQLYFRIQSLFFCGP-RSMKSLEQLLSDPHPTEVFRVNGIYSNMPQFAKAFNCPIGSPMNPEK 706

  Fly   845 KCSVW 849
            ||.::
Worm   707 KCKMF 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	159/695 (23%)
nep-10	NP_494532.2	M13	97..709	CDD:189000	159/696 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920