DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and nep-9

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_494531.2	Gene:	nep-9 / 173683	WormBaseID:	WBGene00017554	Length:	700	Species:	Caenorhabditis elegans

Alignment Length:	795	Identity:	151/795 - (18%)
Similarity:	293/795 - (36%)	Gaps:	185/795 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQEC 178
            :||.|...::  .:|...:|....|.:.   |:.|                      ..|.:.:|
Worm    32 VVLRILNGII--VVGLFTLYTFHFHSKS---RVTP----------------------QFCESPQC 69

  Fly   179 VRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQV--ILRAVLEEP 241
            :..|..|.:..|..:..||||::..|..:       :|..::........::.|  ::|..|:..
Worm    70 IILAQELKAYSDTATKSCEDFYKATCENY-------KDHQALDRHRDCKKRKAVNKLVRGFLQRD 127

  Fly   242 IDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLK--QVLQSLGGWPVIERNWSPPADLSVERLMG 304
            .....:::....|..|..|.::.:    .|..|.  :.::.:|.|||:|.||
Worm   128 ESTFTSESESAIKLIFGKCDELSR----NTSYLDIFKDIKKIGSWPVLEHNW------------- 175

  Fly   305 QLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDRRAYHRYMTQVALL 369
                                |:|..|:..:......|.|.|:.|.:.... :.|:..:    |:.
Worm   176 --------------------KDSMFNLDDVIAKLVKLGSTDFGLFKLELR-KLAFGHF----AVF 215

  Fly   370 LGADPATAAAELEKVVLFETQLVNVSLPEADRHDTS--LVYRKMLLPELQELVPEVQWQEY---- 428
            :.:.......:|||.:|   .::..:..:.||.:.|  |.........|:|...|..:.||
Worm   216 VSSKQEQNIHQLEKTIL---GILKANGIQQDRKELSDDLKDYSDFKNHLKEFYQEETYIEYRLYA 277

  Fly   429 -------------LQAAL-GPGIPL---QEDEPLVTYGLHYLTE---MGKILAHTDRRVVHNYML 473
                         .|.|| ..|:.:   .....|:|....:..|   :|.|:..|.:|.:.|:::
Worm   278 GSIVENLGISSLTTQMALKSTGLDVFNHVNQRTLITNSSLFFGEENNLGMIIQKTPKRTLANFLI 342

  Fly   474 WRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESK 538
            :        |.||....:.....|             .|.|.....|..|...:..|:..|::::
Worm   343 F--------HFIDVMTTDLANATK-------------ACKETLIDLLPRASIQVLSRNFVNEDAQ 386

  Fly   539 EVALEMIHTIRAAFNELLAENDWM---------DDETRAVAKEKADSMNERIG----YPELLTNA 590
            :..::|...::....|::..:.:.         :::.:.:.|.||      ||    ||:.:
Worm   387 DDMVKMAQDLKTKITEMIDNSPFFTKFHLVFDAEEQKKLIQKVKA------IGIVTEYPQEV--- 442

  Fly   591 TELEQEYVNLTIVP-DNFINNVLSILQWESEKMLRLL---RQPVDKEKWTTEPAVVNAFYNPNKN 651
              |::::..|.:.| |:....:..:.:..||:::..|   ..|.|...|.      :|.|:...|
Worm   443 --LDRDFERLNLTPSDSIYRTIQKLRRLRSEQLIEHLGGDLDPTDTRVWG------SAHYDQTTN 499

  Fly   652 DIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFR 716
            ::...|.|:...::...:|..:|...:|.::|.|:....|....:.|::|....|....:::.|.
Worm   500 NLTIFAPIIDGPYFDTSYPNYVNQFLMGFILGRELGRSLDSVRIRKDEKGQTENWLKPESLKRFD 564

  Fly   717 ERTQCVIDQYSRYK---------INEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQ 772
            |..:|..::|.:..         |.::    :||..|.|..||..|.:.::||:.|.:..:  |:
Worm   565 EHLKCWAEKYDKSADPLKSESKGIRQI----EGRYIQNEMFADFIGHEASWRAFMKLDVKN--EE 623

  Fly   773 QLPGLNMTH-DQLFFLNYAQIWCGSMRPEDALTKIRS--AVHSPGFVRVLGPLSNSRDFASAYKC 834
            .|....:.. .::||...|..:|   ||....|...|  ..|.....||.|...|...||.|::|
Worm   624 VLETFKVIKLRRMFFNVQALYFC---RPPSGSTDWLSYQEHHQHYSFRVNGAFKNMPQFALAFEC 685

  Fly   835 PLGSTMNPAEKCSVW 849
            .....|||..|||::
Worm   686 ASDDDMNPQNKCSMF 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	136/711 (19%)
nep-9	NP_494531.2	M13	87..698	CDD:189000	136/709 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910