DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep1 and nep-13

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001342017.1	Gene:	nep-13 / 173672	WormBaseID:	WBGene00018196	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	804	Identity:	185/804 - (23%)
Similarity:	341/804 - (42%)	Gaps:	180/804 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LLVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSG------SAHEGQDN 171
            |:.:.|...::...:||:.::                        |..||.      :.|....:
Worm    42 LISIIICLVIIAICMGAVIVF------------------------WRMDSAPQAICKTDHNKTRD 82

  Fly   172 ICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPED-RSSISTFEVLSDQQQVIL- 234
            :|.|.||:..:::||:..:.|.||||||::|:||.:.: |.:.:. |::.....|:...:|.:|
Worm    83 VCKTAECITLSSTLLNWQNTNIDPCEDFYEYSCGRYQE-HTLNDGIRANEKDTIVMKLIRQFVLK 146

  Fly   235 -----------------RAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLG 282
                             :..|...::.|..:..:..:..|::      |||||:
Worm   147 NQSTTSNSENALMLLYEKCSLRYRMENRHQETEVIQREVFEN------IRKIGS----------- 194

  Fly   283 GWPVIERNWSPPADLSVERLMG------QLRLNYSEPVMIELYVGADDKNSSVN--ILQMDQLQY 339
             ||:.::||: .:..::..::.      .|.....|..:||||    ..|::..  :::..:|::
Worm   195 -WPIADKNWN-SSHFNLNNMLSNMASIHMLPFGLFETRVIELY----PMNTTAKQLVIRPTKLKF 253

  Fly   340 ALPS-------RDYYLKESSANDRRAYHRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLP 397
            ::|.       ||..    |.|.       :|.:...:..|.|.:.| |:|      ::.|:.:.
Worm   254 SIPQEELVRAIRDLL----SVNG-------ITSIMKKVKEDVAESFA-LDK------EIGNIHID 300

  Fly   398 EADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLHYLTEMGK---- 458
            ...:..|        |.|||:.||::.::..:::.|.|............:...:....||
Worm   301 PQPKPAT--------LSELQKAVPDIDFERIIKSYLNPKTGNWSSLRTKIFSARFELFFGKNNNL 357

  Fly   459 --ILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLG 521
              |:|.|..|::.||:..:.:........|..:            :.|:.   ..|.|.....|.
Worm   358 SSIIARTKPRILANYLFLKYIEYAYFFFFDNTK------------VFSDD---DFCTEVVTTSLP 407

  Fly   522 VAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYPEL 586
            .|...:|:|::|.:|:..||.|::..::.|:.|::..:.|:.:.||..|.||...|.:.|||.|.
Worm   408 RASLRVFVRNHFKKENMAVASEIVEVVKTAYVEIINNSTWLHNSTRESAIEKVVKMKKVIGYTEE 472

  Fly   587 LTNATELEQEYVNLTIV-PDNFINNVLSILQWESEKMLRL-----LRQPVDKEKWTTEPAVV-NA 644
            ......|::.:..|.:. .|:|...:..:.:::.|:::..     |..|:       ||.|: ||
Worm   473 YERTGALDEMFETLQLSRSDSFFVLMTKVNRFKIEQLMDFVSSDSLLNPI-------EPLVMANA 530

  Fly   645 FYNPNKN--DIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWW 707
            ||.|.||  :::.|. :.:||| ...:|:.:...|:|.|:.|||.|.||..|||.|:.|....||
Worm   531 FYFPTKNLLNVLVPF-LDKPLF-DFKYPRYVAMAGVGRVLAHEIGHAFDINGRQTDEIGRTRDWW 593

  Fly   708 NNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQ 772
            .....|.:..|::|..:|::.:|........:|.....|.|||..|::.::.|:||
Worm   594 TREDTEEYDRRSECFAEQFTNFKDPSFKGKQNGTEVLAEIIADALGMEASWIAFKK--------- 649

  Fly   773 QLPGLNMTHDQ------------LFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNS 825
                :|:|.:|            |:|...|..:|...|.|:..:...|  |.....|:.|..|||
Worm   650 ----INLTEEQGLIQFEDHDFGKLYFQVAALDFCAPSRIEERYSDQLS--HPTNKFRINGAFSNS 708

  Fly   826 RDFASAYKCPLGSTMNPAEKCSVW 849
            |.||..||||:||.|||.::|.::
Worm   709 RAFADTYKCPVGSKMNPVQRCDMF 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	169/713 (24%)
nep-13	NP_001342017.1	M13	104..729	CDD:189000	169/713 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920