DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and Ecel1

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	817	Identity:	274/817 - (33%)
Similarity:	435/817 - (53%)	Gaps:	57/817 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 QAPHQMQQQQQQQQQNKLPTVVFLAPDGSGGVGIQRGNPAQGN---PGMVTGTG---SHSDWLLK 105
            :||:.|.....:.|:     |.:::..|:||        |:|.   ||...|:|   |.|...|.
Mouse     2 EAPYSMTAHYDEFQE-----VKYVSRCGTGG--------ARGTSLPPGFPRGSGRSASGSRSGLP 53

  Fly   106 ESQQRRRLLVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQD 170
            ...:|...|:..:.|     |.|..||..|.:    .|..|.|   ....|     .|:..||
Mouse    54 RWNRREVCLLSGLVF-----AAGLCAILAAML----ALKYLGP---GAAGG-----GGACPEG-- 99

  Fly   171 NICMTQECVRTAASLLSA-MDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQVIL 234
              |..::....||..||| :|.:.|||:||:.:|||.|.:.|.||:|:.:..|...:.:|.:..|
Mouse   100 --CPERKAFARAARFLSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERL 162

  Fly   235 RAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPV---IERNWSPPAD 296
            |.:|..|.......|..|.:.||:||:|:.:|.::|...:.:|::..|||.:   .:|..:...|
Mouse   163 RRLLARPTGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADRPGAARWD 227

  Fly   297 LSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDR--RAY 359
            |:  ||:.:.:..||...:..|.|..||:|||..::::||....||.|..||.:...:::  .||
Mouse   228 LN--RLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAY 290

  Fly   360 HRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEAD--RHDTSLVYRKMLLPELQELVPE 422
            ..:|.::..|||||.....|  ::::..|.:|.|:|:.|.|  |.|.|..|.|:.|.:||:::|.
Mouse   291 RVFMQRLLRLLGADAVEQKA--QEILQLEQRLANISVSEYDDLRRDVSSAYNKVTLGQLQKIIPH 353

  Fly   423 VQWQEYLQAALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDE 487
            :||:..|......  ...|:|.:|.....|:.::.:::..|.||::|||::||:|:.|..|:...
Mouse   354 LQWKWLLDQIFQE--DFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSP 416

  Fly   488 YQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAF 552
            ::....|..|.:.|....:.....|:...|:..|:|:||||:.::|:..||....:::..|:...
Mouse   417 FREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYIL 481

  Fly   553 NELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQW 617
            .:.|.|.||||.:|:|.|:.|...|...:|||:.|.....:::|| ...:....:..|:|:.:::
Mouse   482 GQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEY-EFEVHEKTYFKNILNSIRF 545

  Fly   618 ESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVI 682
            ..:..::.:||.|||..|...|..:||:|.||||.:|||||||||..|...||:||||||||.:|
Mouse   546 SIQLSVKKIRQEVDKSSWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTII 610

  Fly   683 GHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGEN 747
            |||:|||:||.|.|:|:.||::.||...:...|..:.:|::..|..:.:  .:..::|:.|.|||
Mouse   611 GHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIVRLYDNFTV--YNQRVNGKHTLGEN 673

  Fly   748 IADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHS 812
            |||.||||.|:.||:||...||.|..|..|..||:||||:.:||.||...|.:....::.:..|:
Mouse   674 IADMGGLKLAYYAYQKWVREHGPEHPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLTDKHA 738

  Fly   813 PGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            |...||||.:|...:|..|:.||..|.|||..|||||
Mouse   739 PEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	231/659 (35%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52		7/21 (33%)
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	231/660 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820