DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nep1 and Gm49333

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_808810.1	Gene:	Gm49333 / 110599584	MGIID:	6121518	Length:	910	Species:	Mus musculus

Alignment Length:	816	Identity:	303/816 - (37%)
Similarity:	467/816 - (57%)	Gaps:	63/816 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 PDGSGGVGIQRGN-----PAQGNPGMVTGTGSHS-DWLLKESQQRRRLLV--------------- 115
            |.||..|.:::|.     ..:.:|..|:..|.|: |.:|.|..:.:|..:
Mouse   120 PSGSFDVVLEKGTLDAMLAGEPDPWNVSSEGVHTVDQVLSEMVEYKRAKLRDEESPEITVEGRAT 184

  Fly   116 ---LAIAF-----------TVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAH 166
               |.:.|           |.|...:..|.:..|::...| |..|....|            .||
Mouse   185 RDSLEVGFQKRTRQLFGSHTQLELVLAGLILVLAALLLGC-LVALWVHRD------------PAH 236

  Fly   167 EGQDNICMTQECVRTAASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSISTFEVLSDQQQ 231
                :.|:|:.|:|.|..:|.::|....||:||:|::||.|.:.:|:|..||..:||..|.||.|
Mouse   237 ----STCVTEACIRVAGKILESLDRGVSPCQDFYQFSCGGWIRRNPLPNGRSRWNTFNSLWDQNQ 297

  Fly   232 VILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIERNWSPPAD 296
            .||:.:||.......::|..|.::|:.||:...:|.|:|...|:.::..:|||. |...|...:.
Mouse   298 AILKHLLENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIGGWN-ITGPWDEDSF 361

  Fly   297 LSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSANDR--RAY 359
            :.|.:.:..   .|.......:||.||.|:|:.||:|:||....||||||||.. :||::  .||
Mouse   362 MDVLKAVAG---TYRATPFFTVYVSADSKSSNSNIIQVDQSGLFLPSRDYYLNR-TANEKVLTAY 422

  Fly   360 HRYMTQVALLLGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQ 424
            ..||.::.:|||..|.:...::::|:..|.||.|:::|:..|.|...:|.||.:.|||.|.|.|.
Mouse   423 LDYMVELGVLLGGQPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPAVD 487

  Fly   425 WQEYLQAALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQ 489
            |.|:|...|.| :.|.:.||:|.||..||.::.:::..|:..:::||::|.||....|.:...::
Mouse   488 WLEFLSFLLSP-LELGDSEPVVVYGTEYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFE 551

  Fly   490 RERVEFRKILMGIQSERT-RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFN 553
            ..:.:..:.|.|.:...| ||..|:..|:..||.|:|:||::..|:::|||:|..||:.||:||.
Mouse   552 TAQEKLLETLYGTKKSCTPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRSAFE 616

  Fly   554 ELLAENDWMDDETRAVAKEKADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWE 618
            |.|.:..|||::||..||||||::.:.||:|:.:....||:..|....:..|:|..|:|::..:.
Mouse   617 ETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEVSEDSFFQNMLNLYNFS 681

  Fly   619 SEKMLRLLRQPVDKEKWTTEPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIG 683
            ::.|...||:|..:::|:..|..|||:|.|.||:|||||||||..||:.:.||:||:||||||:|
Mouse   682 AKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMG 746

  Fly   684 HEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKINEVDMFMDGRMTQGENI 748
            ||:||.|||:||::|||||:..||.|.::.||:..|.|:.:|||:|::|  ...::|..|.||||
Mouse   747 HELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQYQVN--GERLNGLQTLGENI 809

  Fly   749 ADNGGLKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSP 813
            |||||||.|:.|||.|...||.||.||.:.:|:.||||:.:||:||....||.:...:.:..|||
Mouse   810 ADNGGLKAAYNAYKAWLRKHGEEQPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSP 874

  Fly   814 GFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849
            ...||||.|||||||...:.||:||.|||.:.|.||
Mouse   875 ARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	268/655 (41%)
Gm49333	NP_808810.1	AdoMet_MTases	63..>128	CDD:302624	4/7 (57%)
		PepO	248..901	CDD:226118	268/660 (41%)
		M13	259..908	CDD:189000	268/656 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61902
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100162
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.830