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Protein Alignment Nep1 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	NP_055508.3	Gene:	EEF1AKMT4-ECE2 / 110599583	HGNCID:	53615	Length:	883	Species:	Homo sapiens

Alignment Length:	850	Identity:	313/850 - (36%)
Similarity:	486/850 - (57%)	Gaps:	73/850 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 NAPLEELSATVVSPLLGQQQVQHQAPHQMQQQQQQQQQNKLPTVVFLAPDGSGGVGIQRGN---- 84
            |....:.|:.||:.:    |.:|  .|..|.:.:.....||.     .|..|..|.:::|.
Human    83 NVTSVDYSSVVVAAM----QARH--AHVPQLRWETMDVRKLD-----FPSASFDVVLEKGTLDAL 136

  Fly    85 -PAQGNPGMVTGTGSHS-DWLLKE---SQQRRRL--------LVLAIAFTVLGA-AIGALAIYFA 135
             ..:.:|..|:..|.|: |.:|.|   .:..|:|        ||||.|..:|.| .:|.|.....
Human   137 LAGERDPWTVSSEGVHTVDQVLSEVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGV 201

  Fly   136 SVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMTQECVRTAASLLSAMDLNSDPCEDFF 200
            ..|:       :|.:                    :.|:|:.|:|.|..:|.::|....|||||:
Human   202 QYHR-------DPSH--------------------STCLTEACIRVAGKILESLDRGVSPCEDFY 239

  Fly   201 QYACGTWNKMHPIPEDRSSISTFEVLSDQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQ 265
            |::||.|.:.:|:|:.||..:||..|.||.|.||:.:||.......::|..|.:.|:.||:.:.:
Human   240 QFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVER 304

  Fly   266 IRKIGTGRLKQVLQSLGGWPVIERNWSPPADLSVERLMGQLRL---NYSEPVMIELYVGADDKNS 327
            |.::|...|:.:::.:|||     |.:.|.|  .:..|..|:.   .|.......:|:.||.|:|
Human   305 IEELGAQPLRDLIEKIGGW-----NITGPWD--QDNFMEVLKAVAGTYRATPFFTVYISADSKSS 362

  Fly   328 SVNILQMDQLQYALPSRDYYLKESSANDR--RAYHRYMTQVALLLGADPATAAAELEKVVLFETQ 390
            :.|::|:||....||||||||.. :||::  .||..||.::.:|||..|.:...::::|:..|.|
Human   363 NSNVIQVDQSGLFLPSRDYYLNR-TANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQ 426

  Fly   391 LVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLHYLTE 455
            |.|:::|:..|.|...:|.||.:.|||.|.|.:.|.|:|...|.| :.|.:.||:|.||:.||.:
Human   427 LANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP-LELSDSEPVVVYGMDYLQQ 490

  Fly   456 MGKILAHTDRRVVHNYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERT-RWSQCVEWTNKK 519
            :.:::..|:..:::||::|.||....|.:...::..:.:..:.|.|.:.... ||..|:..|:..
Human   491 VSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDA 555

  Fly   520 LGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKEKADSMNERIGYP 584
            ||.|:|:||::..|:::|||:|..||..||.||.|.|.:..|||::||..||||||::.:.||:|
Human   556 LGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFP 620

  Fly   585 ELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTTEPAVVNAFYNPN 649
            :.:....||:..|....|..|:|..|:|::..:.::.|...||:|..:::|:..|..|||:|.|.
Human   621 DFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPT 685

  Fly   650 KNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEA 714
            ||:|||||||||..||:::.||:||:||||||:|||:||.|||:||::|||||:..||.|.::.|
Human   686 KNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAA 750

  Fly   715 FRERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWETLHGREQQLPGLNM 779
            ||..|.|:.:||::|::|  ...::||.|.|||||||||||.|:.|||.|...||.|||||.:.:
Human   751 FRNHTACMEEQYNQYQVN--GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGL 813

  Fly   780 THDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAE 844
            |:.||||:.:||:||....||.:...:.:..|||...||||.|||||||...:.||:||.|||.:
Human   814 TNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQ 878

  Fly   845 KCSVW 849
            .|.||
Human   879 LCEVW 883

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.