DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nep1 and kel

DIOPT Version :9

Sequence 1:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster
Sequence 2:	XP_005157998.1	Gene:	kel / 101882278	ZFINID:	ZDB-GENE-110411-118	Length:	759	Species:	Danio rerio

Alignment Length:	815	Identity:	203/815 - (24%)
Similarity:	326/815 - (40%)	Gaps:	172/815 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 RRLLVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEGQDNICMT 175
            ||||:...|.::...|:| |.||       .||.:    ..|....:|...:        .:|::
Zfish    36 RRLLLPPFAVSLFATALG-LGIY-------SHLQK----TADPWKSKWKSAA--------PLCLS 80

  Fly   176 QECVRTAASLLSAMDLNSDPCEDFFQYACGT---------------------------------- 206
            ..|:|.:.....|||..|.|| |:|.:|||.
Zfish    81 PACIRASEHFSVAMDPFSRPC-DYFLFACGAGGSSTNRDRQRVKGEVNKHSEVRTRGLIEMRRGT 144

  Fly   207 --WNKMHPIPEDRSSISTFEVLSDQQQVILRA---VLEEPIDERDN--KATIKAKTFFKSCMDIP 264
              |:|      ....:.||   .|:|..:|.|   :||.| ||..:  .|..|||.||||||:..
Zfish   145 DGWSK------SDGQLKTF---PDRQTALLTAIKEILEAP-DEAVSMGAAEQKAKNFFKSCMNAE 199

  Fly   265 QIRKIGTGRLKQVLQSLGGWPVIERNWS-PPADLSVERLMGQLRLNYSEPVMIELYVGAD--DKN 326
            ...|:|:.....:||.|||| .:...|: ...:.::..||||    ||......:|||.:  ::.
Zfish   200 SREKMGSEPFLTLLQQLGGW-AVSGVWNQTDFNSTLALLMGQ----YSTFPFFNVYVGPEPSEEQ 259

  Fly   327 SSVN--ILQMDQLQYALPSR-DYYLKESSANDR--RAYHRYMTQVALLLGADPATAAAELEKVVL 386
            |:.|  .:|:|:..:..|.. :...:::.||.|  |.::....|..:|||.............|.
Zfish   260 SASNRHYIQIDEPHFQFPIEWNSKTQKAKANTRYLRPFYSACGQYLVLLGVPSDRTTQHCGLFVS 324

  Fly   387 FETQLVNVSLPEADRHDTSLVYRKMLLPELQELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLH 451
            ..|.|...:.|...|....|:||:..:.|||.|.|.|.|...|||...| :.:.:.:.::.:.|.
Zfish   325 LSTTLAVATFPLPYRLSQKLLYRRTTIQELQTLAPAVDWLACLQATFQP-LLISKSDIVLVHNLP 388

  Fly   452 YLTEMGKILAHTDRRVVH---------NYMLWRLVMSLMSHMIDEYQRERVEFRKILMGIQSERT 507
            |:..|.|.: |. .:|.|         .||::.|:.:|:. .:|....:.:....|..|...|..
Zfish   389 YIIHMSKTI-HL-WQVQHELMGTGPLNTYMIFSLLQTLIP-ALDSRFFQIMRNYSIATGDTQEMP 450

  Fly   508 RWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHTIRAAFNELLAENDWMDDETRAVAKE 572
            .|.:||:.|.:.....:... ||:...|:..|   |:|..:.::..:.|.:..|.|::.......
Zfish   451 HWWRCVQQTERGFDTLLSHA-IREKHAQKEAE---ELIQDVYSSLKKKLTDLSWRDEKESDFILN 511

  Fly   573 KADSMNERIGYPELLTNATELEQEYVNLTIVPDNFINNVLSILQWESEKMLRLLRQPVDKEKWTT 637
            |.:|:|.||.......:.|||...|..:.:..::|.:|.|.||..|.:...|||......|..:.
Zfish   512 KINSLNPRISTNTNNLSYTELNHLYEKVILNEEDFFSNYLQILLLEQKSRARLLSLGTQTEGLSM 576

  Fly   638 EPAVVNAFYNPNKNDIVFPAGILQPLFYSQHFPKSLNYGGIGVVIGHEITH----GFDDKGRQFD 698
            .|.:       :.|||:.|.|:....|:...:|::||||.:|.::..::.|    ....|.:..:
Zfish   577 TPFI-------SGNDIIVPVGMFVSPFFHSSYPRALNYGTLGSLMAKDLLHLLLPDIYTKAKNPE 634

  Fly   699 KEGNMMQWWNNATI-------EAF---RERTQCVIDQYSRYKINEVDMFMDGRMTQGENIADNGG 753
            .| ::..|.:..::       :||   ..:.|.|..|||                         .
Zfish   635 TE-SLCVWSHYLSVTKGPGWGDAFYLPSSKQQEVWVQYS-------------------------A 673

  Fly   754 LKQAFRAYKKWETLHGREQQLPGLNMTHDQLFFLNYAQIWCGSMRPEDALTKIRSAVHSPGF-VR 817
            |:.|..|||.....:..:..|||.:..|  ||..::.::.|.:    ||..:....  .|.| |.
Zfish   674 LQVALDAYKMSFKRYLADSSLPGFSYVH--LFLSSFTKVTCDT----DAYREFMPL--EPSFLVT 730

  Fly   818 VLGPLSNSRDFASAYKCPLGST-MN-----PAEKC 846
            ||  .|||.      .||...| ||     |||.|
Zfish   731 VL--CSNSG------LCPKPLTCMNKPQSFPAEMC 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nep1	NP_001284925.1	M13	194..847	CDD:189000	182/732 (25%)
kel	XP_005157998.1	GluZincin	99..>620	CDD:301352	140/551 (25%)
kel	XP_005157998.1	GluZincin	583..>721	CDD:301352	37/169 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0000538
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020