DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mipp2 and PHO12

DIOPT Version :9

Sequence 1:	NP_511055.1	Gene:	Mipp2 / 31544	FlyBaseID:	FBgn0026060	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_012087.1	Gene:	PHO12 / 856625	SGDID:	S000001258	Length:	467	Species:	Saccharomyces cerevisiae

Alignment Length:	421	Identity:	80/421 - (19%)
Similarity:	143/421 - (33%)	Gaps:	104/421 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ADIEGRLSTKT----------PYRAI-ANYDETPPKYAGCHPTRIWTIIRHGTRNPSES---VIL 83
            :||: ::.|:|          ||.:. .:|..:......|...::..:.|||.|.|:.|   .|:
Yeast    26 SDID-KIGTQTEIFPFLGGSGPYYSFPGDYGISRDLPESCEMKQVQMVGRHGERYPTVSKAKSIM 89

  Fly    84 QAQNRLSEIKKR--------------ILDQTKPPICTAELEKLRQWHWMHLNATEDEKLLVAEGE 134
            ....:||....:              .:..||    ..|:|.........||....|........
Yeast    90 TTWYKLSNYTGQFSGALSFLNDDYEFFIRDTK----NLEMETTLANSVNVLNPYTGEMNAKRHAR 150

  Fly   135 DELIELAERMQRR-----FPDLLPELYNPEWYYF-----KYTATQRTLKSAESFATGLFGRHRIH 189
            |.|.:....::.:     |.......::...|:.     |:..:.:|:..|||........|.
Yeast   151 DFLAQYGYMVENQTSFAVFTSNSNRCHDTAQYFIDGLGDKFNISLQTISEAESAGANTLSAHH-- 213

  Fly   190 TVRYPPPLHEDPVLRFYKGCGKWKTDVD----KNPETLVNARRFLAEPQMQSAVEQVRSSTRLPD 250
                              .|..|..||:    |..:|     ::|:     ...:::....:..:
Yeast   214 ------------------SCPAWDDDVNDDILKKYDT-----KYLS-----GIAKRLNKENKGLN 250

  Fly   251 LQPEDVQLMYTVCAFETAWHRPRHDSGSKSSYESVWCNFFDVAALEALEFFEDLEYYWNDGYGYE 315
            |...|....:..||:|.          :...|..: ||.|....|....:.:|||.|:..|.||:
Yeast   251 LTSSDANTFFAWCAYEI----------NARGYSDI-CNIFTKDELVRFSYGQDLETYYQTGPGYD 304

  Fly   316 LTHRIACPAIADMF-AAISSSEETRQRRANATLYFTHSGTLLKLLAHLGLARDNKPLTHKHF--- 376
            :...:.    |::| |::...:|:..:.....|.|||...:|..|..:|:..|...||.:|.
Yeast   305 VVRSVG----ANLFNASVKLLKESEVQDQKVWLSFTHDTDILNYLTTIGIIDDQNNLTAEHVPFM 365

  Fly   377 --ASERLWRTSQ-----IDAF-ATNLAFLRY 399
              ...|.|...|     .:.| .:|..::||
Yeast   366 ENTFHRSWYVPQGARVYTEKFQCSNDTYVRY 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mipp2	NP_511055.1	HP	68..351	CDD:299704	56/314 (18%)
PHO12	NP_012087.1	His_Phos_2	65..399	CDD:395259	72/381 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1382
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55377
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101372
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.650