DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mipp2 and PHO5

DIOPT Version :9

Sequence 1:	NP_511055.1	Gene:	Mipp2 / 31544	FlyBaseID:	FBgn0026060	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_009651.3	Gene:	PHO5 / 852390	SGDID:	S000000297	Length:	467	Species:	Saccharomyces cerevisiae

Alignment Length:	428	Identity:	85/428 - (19%)
Similarity:	164/428 - (38%)	Gaps:	68/428 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFLLLLHFFVGVTLSEEGECRRLNRADIEGRLSTKT---PYRAIAN-YDETPPKYA-------GC 61
            :|..:::..:..:|:..|.......||:: ::.|:.   |:...|. |...|..|.       ||
Yeast     1 MFKSVVYSILAASLANAGTIPLGKLADVD-KIGTQKDIFPFLGGAGPYYSFPGDYGISRDLPEGC 64

  Fly    62 HPTRIWTIIRHGTRNPSESV---ILQAQNRLSEIKKRILDQTKPPICTAELEKLRQWHWMHLNAT 123
            ...::..:.|||.|.|:.|:   |.....:||...::.         ...|..|...:...:...
Yeast    65 EMKQLQMVGRHGERYPTVSLAKTIKSTWYKLSNYTRQF---------NGSLSFLNDDYEFFIRDD 120

  Fly   124 EDEKL--LVAEGEDELIELAERM--QRRFPDLLPE---LYNPEWYYFKYTA-TQRTLKSAESFAT 180
            :|.::  ..|..:|.|......|  :|...|.|.:   :...:..:..:|: ::|...:|:.|..
Yeast   121 DDLEMETTFANSDDVLNPYTGEMNAKRHARDFLAQYGYMVENQTSFAVFTSNSKRCHDTAQYFID 185

  Fly   181 GLFGRHRI--HTVRYPPPLHEDPVLRFYKGCGKWKTDVDKNPETLVNARRFLAEPQMQSAVEQVR 243
            ||..:..|  .||........: .|.....|..|  |.|.| :.:||.   .....:....:::.
Yeast   186 GLGDQFNITLQTVSEAESAGAN-TLSACNSCPAW--DYDAN-DDIVNE---YDTTYLDDIAKRLN 243

  Fly   244 SSTRLPDLQPEDVQLMYTVCAFETAWHRPRHDSGSKSSYESVWCNFFDVAALEALEFFEDLEYYW 308
            ...:..:|...|...:::.||||.          :...|..| |:.|....|....:::||..|:
Yeast   244 KENKGLNLTSTDASTLFSWCAFEV----------NAKGYSDV-CDIFTKDELVHYSYYQDLHTYY 297

  Fly   309 NDGYGYELTHRIACPAIADMF-AAISSSEETRQRRANATLYFTHSGTLLKLLAHLGLARDNKPLT 372
            ::|.||::...:.    :::| |::...:::..:.....|.|||...:|..|...|:..|...||
Yeast   298 HEGPGYDIIKSVG----SNLFNASVKLLKQSEIQDQKVWLSFTHDTDILNFLTTAGIIDDKNNLT 358

  Fly   373 HKHF-----ASERLWRTSQ-----IDAF-ATNLAFLRY 399
            .::.     ...|.|...|     .:.| .:|..::||
Yeast   359 AEYVPFMGNTFHRSWYVPQGARVYTEKFQCSNDTYVRY 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mipp2	NP_511055.1	HP	68..351	CDD:299704	57/296 (19%)
PHO5	NP_009651.3	His_Phos_2	65..399	CDD:395259	72/363 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346147
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1382
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5846
OMA	1	1.010	-	-		QHG55377
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101372
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R957
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.630