DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mipp2 and Minpp1

DIOPT Version :9

Sequence 1:	NP_511055.1	Gene:	Mipp2 / 31544	FlyBaseID:	FBgn0026060	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	NP_034929.1	Gene:	Minpp1 / 17330	MGIID:	1336159	Length:	481	Species:	Mus musculus

Alignment Length:	474	Identity:	128/474 - (27%)
Similarity:	207/474 - (43%)	Gaps:	71/474 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LSEEGECRRLNRAD-----IEGRLSTKTPYRAIAN----YDETPPK-----YAG-CHPTRIWTII 70
            ||....|....|.|     :.....|||.|.. ||    .|...|:     .|| |.|.::..:|
Mouse    24 LSSFARCSLPGRGDPVASVLSPYFGTKTRYED-ANPWLLVDPVAPRRDPELLAGTCTPVQLVALI 87

  Fly    71 RHGTRNPSESVILQAQNRLSEIKKRILDQTKPPICTAELEKLRQW-----HWMHLNATEDEKLLV 130
            |||||.|:...|.:.:.....::.|........:..|    |.:|     .||       :..||
Mouse    88 RHGTRYPTTKQIRKLKQLQGLLQTRESRDGGSQVAAA----LAEWPLWYGDWM-------DGQLV 141

  Fly   131 AEGEDELIELAERMQRRFPDLLPELYNPEWYYFKYTATQRTLKSAESFATGLFGRHR-------I 188
            .:|..::.:||.|:...||||... .|.:......::..|.:.|:.:|..||:..:.       :
Mouse   142 EKGRQDMRQLALRLAALFPDLFSR-ENYDRLRLITSSKHRCVDSSAAFLQGLWQHYHPGLPPPDV 205

  Fly   189 HTVRYPPPLHEDPVLRFYKGCGKWKTDVDKNPETLVNARRFLAEPQMQSAVEQVRSSTRLP--DL 251
            ..:...||...|.::||:..|.|:.|||::|...|.:...|...|:||..:::|.::.::|  .|
Mouse   206 SDMECGPPRINDKLMRFFDHCEKFLTDVERNETALYHVEAFKTGPEMQKVLKKVAATLQVPMNSL 270

  Fly   252 QPEDVQLMYTVCAFETA---WHRPRHDSGSKSSYESVWCNFFDVAALEALEFFEDLEYYWNDGYG 313
            ..:.:|:.:..|:|:.|   .|.|             ||:.|||.....||:..||:.||...||
Mouse   271 NADLIQVAFFTCSFDLAIKGVHSP-------------WCDVFDVDDARVLEYLNDLKQYWKRSYG 322

  Fly   314 YELTHRIACPAIADMFAAISSSEETRQR----RANATLYFTHSGTLLKLLAHLGLARDNKPLTHK 374
            |.:..|.:|....|:|..:..:.|.:||    .:...|.|.|:.|||.||:.:|..:|.:|||..
Mouse   323 YTINSRSSCNLFQDIFLHLDKAVEQKQRSQPVSSPVILQFGHAETLLPLLSLMGYFKDKEPLTAY 387

  Fly   375 HFASE--RLWRTSQIDAFATNLAFLRYDCDKGNP-----QVLVLHQERVVRLPGCPQDKDLCPLA 432
            :|..:  |.:|:..|..:|:||.|:.|.||....     |:.:|..|:|  ||.....:.:....
Mouse   388 NFEEQVNRKFRSGHIVPYASNLIFVLYHCDNAQSPEEQFQIQLLLNEKV--LPLAHSQRPVGLYE 450

  Fly   433 TLRRIYANSVDHCDREKMC 451
            .|:..|.:.:..|...|.|
Mouse   451 ELKTHYRDILQSCQTSKEC 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mipp2	NP_511055.1	HP	68..351	CDD:299704	78/303 (26%)
Minpp1	NP_034929.1	HP_HAP_like	82..429	CDD:132717	101/371 (27%)
Minpp1	NP_034929.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	478..481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849304
Domainoid	1	1.000	143	1.000	Domainoid score	I4638
eggNOG	1	0.900	-	-		E1_KOG1382
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37980
Inparanoid	1	1.050	154	1.000	Inparanoid score	I4307
Isobase	1	0.950	-	0	Normalized mean entropy	S5846
OMA	1	1.010	-	-		QHG55377
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004136
OrthoInspector	1	1.000	-	-		otm42375
orthoMCL	1	0.900	-	-		OOG6_101372
Panther	1	1.100	-	-	O	PTHR20963
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R957
SonicParanoid	1	1.000	-	-		X3401
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740