DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mipp2 and AgaP_AGAP003555

DIOPT Version :9

Sequence 1:	NP_511055.1	Gene:	Mipp2 / 31544	FlyBaseID:	FBgn0026060	Length:	453	Species:	Drosophila melanogaster
Sequence 2:	XP_313302.4	Gene:	AgaP_AGAP003555 / 1274214	VectorBaseID:	AGAP003555	Length:	451	Species:	Anopheles gambiae

Alignment Length:	451	Identity:	192/451 - (42%)
Similarity:	260/451 - (57%)	Gaps:	30/451 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFLLLLHFFVGVTLSE----EGECRRLNRADIEGRLSTKTPYRAIANYD-ETPPKYAGCHPTRIW 67
            |.|.||..|..:.||.    |..|....:..|..||.||||||.:.|.| .:.....||..::||
Mosquito    11 LLLALLVSFSSILLSSSVGAERWCANNPKDTIFRRLGTKTPYRHVQNKDVRSIATVNGCTVSKIW 75

  Fly    68 TIIRHGTRNPSESVILQAQNRLSEIKKRILDQTKPPICTAELEKLRQWHWMHLNATEDEKLLVAE 132
            .:.||||||||:|:|...:..|.|:::.||:...  ||..:||...:  |......||.||||.|
Mosquito    76 GLFRHGTRNPSKSIIDHMRTTLPELQRDILEHGH--ICRDQLELFER--WQPRVTVEDAKLLVRE 136

  Fly   133 GEDELIELAERMQRRFPDLLPELYNPEWYYFKYTATQRTLKSAESFATGLFGRHRIHTVRYPPPL 197
            |.|||.:|.:|:::||...:||.|:...:.||:|.|:|...||.:|:.|||||.  ..::||..|
Mosquito   137 GGDELFQLGQRIRKRFGTHIPERYDEHDFRFKFTKTERAEYSARNFSHGLFGRD--EPIQYPEAL 199

  Fly   198 HEDPVLRFYKGCGKWKTDVDKNPETLVNARRFLAEPQMQSAVEQVRSSTRLPD-LQPEDVQLMYT 261
            |.||||||||||.|||..|.:||.:.....||.:..||:|.:|::  |.|:.. :.||:|..:|.
Mosquito   200 HRDPVLRFYKGCEKWKKQVKQNPYSYREMDRFGSSKQMRSVIEKL--SKRIGTFVSPEEVHAIYQ 262

  Fly   262 VCAFETAWHRPRHDSGSKSSYE-SVWCNFFDVAALEALEFFEDLEYYWNDGYGYELTHRIACPAI 325
            .|||||||          |..: |.||..||..::..:|:.|||:|||.|||||:||||.||.|.
Mosquito   263 TCAFETAW----------SDRDISPWCLLFDKESISTMEYNEDLKYYWIDGYGYDLTHRQACSAF 317

  Fly   326 ADMFAAISSSEETRQRRANATLYFTHSGTLLKLLAHLGLARDNKPLTHKHFASERLWRTSQIDAF 390
            ||:|...:.....|     .|.||||||||||.:|.|.|.:||:||..::...:|.||.|.||||
Mosquito   318 ADLFTNFNDENGPR-----FTFYFTHSGTLLKSIAFLNLYKDNEPLRGENMRHKRKWRVSHIDAF 377

  Fly   391 ATNLAFLRYDCDKGNPQVLVLHQERVVRLPGCPQDKDLCPLATLRRIYANSVDHCDREKMC 451
            .|||.|:.|.|..|...:.:.||||:..:||||:|..||.....:::||:.::.||...||
Mosquito   378 GTNLYFVLYGCPDGTQSIALYHQERLTNIPGCPEDVPLCSYDHFKQMYADRIEQCDLSAMC 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mipp2	NP_511055.1	HP	68..351	CDD:299704	121/284 (43%)
AgaP_AGAP003555	XP_313302.4	HP	77..394	CDD:299704	151/339 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	274	1.000	Domainoid score	I4267
eggNOG	1	0.900	-	-		E1_KOG1382
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37980
Inparanoid	1	1.050	345	1.000	Inparanoid score	I4562
OMA	1	1.010	-	-		QHG55377
OrthoDB	1	1.010	-	-		D1046588at2759
OrthoFinder	1	1.000	-	-		FOG0004136
OrthoInspector	1	1.000	-	-		oto107925
Panther	1	1.100	-	-	LDO	PTHR20963
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3401
TreeFam	1	0.960	-	-
	13	12.940