DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raptor and RAPTOR2

DIOPT Version :9

Sequence 1:	NP_001284924.1	Gene:	raptor / 31543	FlyBaseID:	FBgn0029840	Length:	1621	Species:	Drosophila melanogaster
Sequence 2:	NP_195797.3	Gene:	RAPTOR2 / 831681	AraportID:	AT5G01770	Length:	1336	Species:	Arabidopsis thaliana

Alignment Length:	1611	Identity:	555/1611 - (34%)
Similarity:	768/1611 - (47%)	Gaps:	373/1611 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 SLNDLGKVISNMRQDQSLVPIVKHIEQISDIQASNGQELASLGSLRELIRTIRKEWPRDDSIKLR 159
            :|.||  ::|.:.| .|:..:..|:....|..||:.                     .|||
plant     2 ALGDL--MVSRLSQ-SSVTVVTNHLYDDDDNCASSA---------------------HDDS---- 38

  Fly   160 LKEIQILGMPPARSLCFGERIRDDRCPLSLQTK-------------RHKERIQAMMYERQPWRIR 211
              .:.|:..|...|..:..        ||..|.             ||.:....:...|  ||::
plant    39 --RVSIIASPRVASSSYEN--------LSAATSMAYLPQTLVLCDLRHDDASDIVQPPR--WRLK 91

  Fly   212 ERMKTASVALVLCLNIGVDPPDVVKIQPCSRLECWIDPSSVSPP-KAMELIGSNLQMQYERWQPR 275
            |||||..||||:||:|.||||||:||.||:||||||||.|:.|| :|:|.||.||.:|||||..|
plant    92 ERMKTGCVALVMCLHITVDPPDVIKISPCARLECWIDPFSMFPPRRALEAIGQNLSIQYERWLAR 156

  Fly   276 ARYKKCNDPTVDDVKKLCTSLRRNAKGERILFHYNGHGVPKPTANGEIWVFNKTFTQYIPLSIFE 340
            ||||...|||.|||:|||.|.|:.||.||:|||||||||||||.||||||:||.|||||||.:.|
plant   157 ARYKVELDPTKDDVRKLCLSCRKYAKTERVLFHYNGHGVPKPTPNGEIWVYNKNFTQYIPLPVSE 221

  Fly   341 LITWMSAPSIYVYDCSNAGIIINSFQPYAKQHEEELGKALAAAQQRGGVQQLVGGSGGAANVAAN 405
            |.:|:..|:|||:|||.|.:|:|:|..                          |.|.|..
plant   222 LDSWLKTPTIYVFDCSAARVILNAFAE--------------------------GESSGPP----- 255

  Fly   406 QVQLTNQMVSYKNCIHLAACAANEILPMNAQLPADLFTSCLTTPINIALKWYAMQEKLGMVPRIQ 470
                       |:||.||||..:|.||.:.:.|||:|||||||||||||||:..:..|...  |.
plant   256 -----------KDCILLAACDVHETLPQSVEFPADVFTSCLTTPINIALKWFCRRSLLKEF--ID 307

  Fly   471 SELIDKIPGKVNDRRTMMGELNWIFTAITDTIAWNTLPRELFQRLFRQDLLVASLFRNFLLAERI 535
            ..|||:|||:.|||:|::|||||||||:|||||||.|||||||||||||||||||||||||||||
plant   308 ESLIDRIPGRQNDRKTLLGELNWIFTAVTDTIAWNVLPRELFQRLFRQDLLVASLFRNFLLAERI 372

  Fly   536 LRSHDCTPVSLPALPPCYRHPMWKAWDLVVDLALQQLPE-ILDHNAPYRQLPFFEHQLTAFQVWL 599
            :||.:|||:|.|.|||.::|.||.|||:..::.|.|||: .||.|..::...||..|||||:|||
plant   373 MRSGNCTPISHPMLPPTHQHHMWDAWDMAAEICLSQLPQFFLDPNTEFQPSSFFTEQLTAFEVWL 437

  Fly   600 DSESESRTPPEQLPIVLQVLLSQVHRLRALELLARFLDLGPWAVNLALGVGIFPYVLKLLQSSTR 664
            |..||.:.|||||||||||||||.||.|||.||.||||:|||||:|||.|||:|.|:||||::|.
plant   438 DHGSEHKKPPEQLPIVLQVLLSQCHRYRALVLLGRFLDMGPWAVDLALSVGIYPCVVKLLQTTTI 502

  Fly   665 ELRPVLVFIWAKILAVDPSCQVDLVKE--YKYFLSVLQDTSVSKEHRTLSAFVLSSIVHNFLLGQ 727
            |||.:|||||.||||:|.||||||||:  :.||:..|..:....|.|.::||:|:.||..:..||
plant   503 ELRQILVFIWTKILALDKSCQVDLVKDRGHIYFIRFLDSSDAFPEQRAMAAFILAVIVDGYKRGQ 567

  Fly   728 TSALQGPLLSICLEQLNDGSW-------LLRQWLAICLGMLWQNFEKARWSGARDLAHEKLYVLL 785
            .|.|:..|:::||..|.....       |..|||.:|||.||:::.:|:..|....|.|.| :..
plant   568 ESCLEANLIAVCLGHLEATQLCDPPPEPLFLQWLCLCLGKLWEDYLEAQIMGREANASENL-IAG 631

  Fly   786 RDSIPEVRAAAVFALGTFI-------SSVTDRSEEQANNIDRIIAITMLETVGEDMSPLVRMELA 843
            ..::.:|||||||||||.:       ..|.|...:...||...|.|..|..|..|.|||||.|:|
plant   632 HTNLLQVRAAAVFALGTLLDVGFDSGKGVCDEEFDDDENIVEDIIIKSLLDVVSDGSPLVRTEVA 696

  Fly   844 AAL--------QWMVVLFESQF-----VAVYLTEHMRGHVSAASFVMCPDPRDLTSSTHSLERHV 895
            .||        |.:..:.:|.:     :...|....:.|.|..|.|...|...||.:  |.:...
plant   697 VALARFAFGHKQHLKSVADSYWKPQNSLRTSLPSMAKFHDSGTSIVASSDMGSLTRA--SPDSQP 759

  Fly   896 TIRRGASSSSISNMGGASISSGTGSSSNPLGRSKSGSGSSGGRGAAGAAGGT--------NSIPF 952
            ..|.|..|||:...     .||....| ||. ..|...|..|....|.:.|.        |:|..
plant   760 VAREGRISSSLQEP-----FSGLMQGS-PLA-DDSSLHSDVGIIHDGVSNGVVHQPRPLDNAIYS 817

  Fly   953 QSIFTKLWLGICNLAQDPFPRVAAIAQEIVEHVRDTALCPIMAAKEATMANASEKCSSLSVSLPP 1017
            ||:     |.:..||:||.||:|::.:.::.         ::..::.             |:.|.
plant   818 QSV-----LAMFTLAKDPSPRIASLGRRVLS---------VIGIEQI-------------VAKPS 855

  Fly  1018 SPNTRVNYLGGGGAPGGAGATAESPPVGAAASGASHWAQKLRLSGSGACMGAG------------ 1070
            ..|         |.||.|.:.:.:|..|...|  |.|..          |..|
plant   856 KSN---------GRPGEAASASHTPLAGLVRS--SSWFD----------MHTGHLPLTFRTPPVS 899

  Fly  1071 DPQT--------ILQRKLRTSSINDETDSGPGYSRGVAGAGTGLGLPSGPRESTHSARSSGSESN 1127
            .|||        :...:||...:. ..|||.        |...||:             ||||
plant   900 PPQTSYLTGLRRVCSLELRPHLLG-SPDSGL--------ADPILGV-------------SGSE-- 940

  Fly  1128 HYLEPGHSLTPIVLTEFIPWAISYFTRPGKERYSSAEGSAEEGRQRFPVDRNSAELRRRRLRFLR 1192
                  .||.|  .:....|:..:|::|   ....|:.:.|...||        |.:::
plant   941 ------RSLLP--QSTIYNWSCGHFSKP---LLGGADANEEIAAQR--------EEKKK------ 980

  Fly  1193 NDFVRRHAGR-KHQELIDPYGFDVCVWNRKTQFTPSIVKLLPYEPQIAVA-YREKVLVYDFQYNS 1255
              |...|..: :|..:.......:..|:.|.:.......|.|:.|.:..| ..|::.|::::..:
plant   981 --FSLEHIAKCQHSSISGLSNIPIANWDTKFETGTKTALLHPFSPIVVAADENERIRVWNYEEAT 1043

  Fly  1256 VRTYGAESLGGNFTGYSSGYGSGSGSSSSLNGSTPRKSGAHTSGGGGGGFSAAPFARVSSIEFIN 1320
            :           ..|:.             |...|.|.                   :|::..:|
plant  1044 L-----------LNGFD-------------NNDFPDKG-------------------ISNLCLVN 1065

  Fly  1321 AQDMALNLVA--------HEDGVVRVWQSSPPASSATSEDTPSKARLVTAWTALGQVNQHNHRQR 1377
            ..|.:|.|||        .....:|:|:...         |..:.:|||.::::.
plant  1066 ELDDSLLLVASCNVPTLSRASFAIRIWKDYA---------TKGRQKLVTGFSSIQ---------- 1111

  Fly  1378 SVASGGSIGKGADASGLSSAAIGSGGIVTAWQQCSQHLVIGGGGCRFIRIWDVERELKLADIPLG 1442
                    |:...||||::        |..|||.|.:|.:.|.... |.:||:::|..:..:|.
plant  1112 --------GQKPGASGLNA--------VVDWQQQSGYLYVSGESLS-IMVWDLDKEQLVKSMPF- 1158

  Fly  1443 RSETCARVLSPYLPNMRSDVILAGCDDGSVRLFDKRCAPQDAGISVYRRHS--APILHASLRANG 1505
              |:...|.:.....:....:.||..||||||:|.|  ..|..:...|.|.  ..::..|.:. |
plant  1159 --ESGCSVTALSASQVHGSQLAAGFADGSVRLYDVR--TPDFLVCATRPHQRVEKVVGLSFQP-G 1218

  Fly  1506 L---VLVSGCTEGRISVADMRGSQSSINPFDVVYEWDA-GGDVTAITSHQLEDTVACGNASKIV- 1565
            |   .:||....|.|...|:|      .|.:.....|| .|.:||:..|:....:|.|:|.:::
plant  1219 LDPAKIVSASQAGDIQFLDLR------RPKETYLTIDAHRGSLTALGVHRHAPIIASGSAKQLIK 1277

  Fly  1566 IYSLDGRQQKVLRTNEGFIGPKIGHPTYLYFHPYKAQLAVGFVDNTVAIYS 1616
            ::||.|.|..:::.:..|:|.:||..:.|.||||:..||.|...:.|::|:
plant  1278 VFSLKGEQLGIIKYHTSFMGQQIGPVSCLAFHPYQMLLAAGAAGSFVSLYT 1328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raptor	NP_001284924.1	Raptor_N	219..365	CDD:291222	100/146 (68%)
		HEAT repeat	612..634	CDD:293787	18/21 (86%)
		HEAT repeat	646..684	CDD:293787	25/37 (68%)
		HEAT repeat	694..724	CDD:293787	10/29 (34%)
		HEAT repeat	734..760	CDD:293787	10/32 (31%)
		HEAT_2	743..847	CDD:290374	44/125 (35%)
		HEAT repeat	774..803	CDD:293787	13/28 (46%)
		HEAT repeat	822..848	CDD:293787	14/33 (42%)
		WD40	<1296..1617	CDD:225201	82/336 (24%)
		WD40	1400..>1617	CDD:295369	64/224 (29%)
		WD40 repeat	1448..1489	CDD:293791	12/40 (30%)
		WD40 repeat	1496..1539	CDD:293791	10/45 (22%)
		WD40 repeat	1544..1581	CDD:293791	10/37 (27%)
		WD40 repeat	1588..1615	CDD:293791	11/26 (42%)
RAPTOR2	NP_195797.3	Raptor_N	99..246	CDD:291222	100/146 (68%)
		WD40	966..>1320	CDD:225201	99/460 (22%)
		WD40	1018..1327	CDD:295369	91/399 (23%)
		WD40 repeat	1059..1108	CDD:293791	13/57 (23%)
		WD40 repeat	1124..1158	CDD:293791	10/34 (29%)
		WD40 repeat	1164..1203	CDD:293791	12/40 (30%)
		WD40 repeat	1211..1248	CDD:293791	10/43 (23%)
		WD40 repeat	1255..1290	CDD:293791	10/34 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	550	1.000	Domainoid score	I52
eggNOG	1	0.900	-	-		E1_KOG1517
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80210
Inparanoid	1	1.050	764	1.000	Inparanoid score	I101
OMA	1	1.010	-	-		QHG55294
OrthoDB	1	1.010	-	-		D97083at2759
OrthoFinder	1	1.000	-	-		FOG0004448
OrthoInspector	1	1.000	-	-		otm2643
orthoMCL	1	0.900	-	-		OOG6_101923
Panther	1	1.100	-	-	O	PTHR12848
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3153
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840