DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raptor and RPTOR

DIOPT Version :9

Sequence 1:	NP_001284924.1	Gene:	raptor / 31543	FlyBaseID:	FBgn0029840	Length:	1621	Species:	Drosophila melanogaster
Sequence 2:	NP_065812.1	Gene:	RPTOR / 57521	HGNCID:	30287	Length:	1335	Species:	Homo sapiens

Alignment Length:	1524	Identity:	650/1524 - (42%)
Similarity:	865/1524 - (56%)	Gaps:	265/1524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 EIQILGMPPARSLCFGER----IRDDRCPLSLQTKRHKERIQAMMYERQPWRIRERMKTASVALV 222
            |.::|..|   .|..||.    :.|...||:...|||.|:|:......|.||:::||||.|||||
Human     2 ESEMLQSP---LLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWRMKDRMKTVSVALV 63

  Fly   223 LCLNIGVDPPDVVKIQPCSRLECWIDPSSVSPPKAMELIGSNLQMQYERWQPRARYKKCNDPTVD 287
            ||||:|||||||||..||:||||||||.|:.|.||:|.||:|||.|||.||||||||:..|||||
Human    64 LCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALETIGANLQKQYENWQPRARYKQSLDPTVD 128

  Fly   288 DVKKLCTSLRRNAKGERILFHYNGHGVPKPTANGEIWVFNKTFTQYIPLSIFELITWMSAPSIYV 352
            :|||||||||||||.||:||||||||||:||.|||:|||||.:||||||||::|.|||.:|||:|
Human   129 EVKKLCTSLRRNAKEERVLFHYNGHGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFV 193

  Fly   353 YDCSNAGIIINSFQPYAKQHEEELGKALAAAQQRGGVQQLVGGSGGAANVAANQVQLTNQM---V 414
            |||||||:|:.||:.:|.|.|:||..|                       |.|......||   .
Human   194 YDCSNAGLIVKSFKQFALQREQELEVA-----------------------AINPNHPLAQMPLPP 235

  Fly   415 SYKNCIHLAACAANEILPMNAQLPADLFTSCLTTPINIALKWYAMQEKLGMVPRIQSELIDKIPG 479
            |.||||.||||.|.|:|||...||||||||||||||.|||:|:.||:.:.:||.:..:||:||||
Human   236 SMKNCIQLAACEATELLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG 300

  Fly   480 KVNDRRTMMGELNWIFTAITDTIAWNTLPRELFQRLFRQDLLVASLFRNFLLAERILRSHDCTPV 544
            ::|||||.:|||||||||||||||||.|||:|||:|||||||||||||||||||||:||::||||
Human   301 RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSYNCTPV 365

  Fly   545 SLPALPPCYRHPMWKAWDLVVDLALQQLPEILDHNAPYRQLPFFEHQLTAFQVWLDSESESRTPP 609
            |.|.|||.|.|.||:||||.||:.|.|||.|::....:|..|||..|||||||||....|:|.||
Human   366 SSPRLPPTYMHAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLTMGVENRNPP 430

  Fly   610 EQLPIVLQVLLSQVHRLRALELLARFLDLGPWAVNLALGVGIFPYVLKLLQSSTRELRPVLVFIW 674
            ||||||||||||||||||||:||.||||||||||:|||.||||||||||||||.|||||:|||||
Human   431 EQLPIVLQVLLSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIW 495

  Fly   675 AKILAVDPSCQVDLVKE--YKYFLSVLQDTSVSKEHRTLSAFVLSSIVHNFLLGQTSALQGPLLS 737
            |||||||.|||.||||:  :|||||||.|..:..||||::||:|:.||:::..||.:.|||.|::
Human   496 AKILAVDSSCQADLVKDNGHKYFLSVLADPYMPAEHRTMTAFILAVIVNSYHTGQEACLQGNLIA 560

  Fly   738 ICLEQLNDGSWLLRQWLAICLGMLWQNFEKARWSGARDLAHEKLYVLLRDSIPEVRAAAVFALGT 802
            ||||||||...|||||:|||||.:||||:.|||.|.||.||||||.||.|.|||||.||||||||
Human   561 ICLEQLNDPHPLLRQWVAICLGRIWQNFDSARWCGVRDSAHEKLYSLLSDPIPEVRCAAVFALGT 625

  Fly   803 FISSVTDRSEEQANNIDRIIAITMLETVGEDMSPLVRMELAAALQWMVVLFESQF--VAVYLTEH 865
            |:.:..:|: :.:..||..:|: ||..:..|.||:||.||..||..:||.:||.|  ||:...|.
Human   626 FVGNSAERT-DHSTTIDHNVAM-MLAQLVSDGSPMVRKELVVALSHLVVQYESNFCTVALQFIEE 688

  Fly   866 MRGHVSAASFVMCPDP-----------RD--LTSSTHSLERHVTIRRGASSSSIS-NMGGASISS 916
            .:.:.       .|.|           ||  .|....|:..:..||..|::.|:: ::...|::.
Human   689 EKNYA-------LPSPATTEGGSLTPVRDSPCTPRLRSVSSYGNIRAVATARSLNKSLQNLSLTE 746

  Fly   917 GTGS----SSNPLGRSKSGSGSSGG---------------RGAAGAAGGTNS---IPFQSIFTKL 959
            .:|.    |...|..|.|.|.:.|.               ...|.:....||   :.|.|::|::
Human   747 ESGGAVAFSPGNLSTSSSASSTLGSPENEEHILSFETIDKMRRASSYSSLNSLIGVSFNSVYTQI 811

  Fly   960 WLGICNLAQDPFPRVAAIAQEIVEHVRDTALCPIMAAKEATMANASEK----CSSLSVSLPPSP- 1019
            |..:.:||.||:|.|:.:|.:::..:          |.:||: ||..:    .|||:.|.|.||
Human   812 WRVLLHLAADPYPEVSDVAMKVLNSI----------AYKATV-NARPQRVLDTSSLTQSAPASPT 865

  Fly  1020 NTRVNYLGGGGAPGGAGATAESPPVGAAASGASHWAQKLRLSGSGACMGAGDPQTILQRKLRTSS 1084
            |..|:....||          |||..:.:|.:                        |...:....
Human   866 NKGVHIHQAGG----------SPPASSTSSSS------------------------LTNDVAKQP 896

  Fly  1085 INDETDSGPGYSRGVAGA----------GTGLGLPSGPRESTHSARSSGSESNHYLEPGHS--LT 1137
            ::.:..||...:.|.|||          .|......||.::...|..:.         ||.  ::
Human   897 VSRDLPSGRPGTTGPAGAQYTPHSHQFPRTRKMFDKGPEQTADDADDAA---------GHKSFIS 952

  Fly  1138 PIVLTEFIPWAISYFTRPGKERYSSAEGSAEEGRQRFPVDRN-SAELRR-RRLRFLRNDFVRRHA 1200
            ..|.|.|..|:..||.:|               ..:.|.:.: .:::|: |..|||||..|||.|
Human   953 ATVQTGFCDWSARYFAQP---------------VMKIPEEHDLESQIRKEREWRFLRNSRVRRQA 1002

  Fly  1201 GRKHQELIDPYGFDVCVWNRKTQFTPSIVKLLPYEPQIAVAYREKVLVYDFQYNSVRTYGAESLG 1265
            .:..|:.|.  ..|..::..:....||:||..|:.|.||||.::.:..:|::......|
Human  1003 QQVIQKGIT--RLDDQIFLNRNPGVPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDY------ 1059

  Fly  1266 GNFTGYSSGYGSGSGSSSSLNGSTPRKSGAHTSGGGGGGFSAAPFARVSSIEFINAQDMALNLVA 1330
                               .:...||                  :.||:::|::|.||.:|.|.|
Human  1060 -------------------FHNGNPR------------------YTRVTAMEYLNGQDCSLLLTA 1087

  Fly  1331 HEDGVVRVWQSSPPASSATSEDTPSKARLVTAWTALGQVNQHNHRQRSVASGGSIGKGADASGLS 1395
            .:||.:|||:     :.|..|..|   .:||||..|..:....             :||
Human  1088 TDDGAIRVWK-----NFADLEKNP---EMVTAWQGLSDMLPTT-------------RGA------ 1125

  Fly  1396 SAAIGSGGIVTAWQQCSQHLVIGGGGCRFIRIWDVERELKLADIPLGRSETCARVLSPYLPNMRS 1460
                   |:|..|:| ...|::..|..|.:||||.:||:|:.|||.| :::|...||  ..:.||
Human  1126 -------GMVVDWEQ-ETGLLMSSGDVRIVRIWDTDREMKVQDIPTG-ADSCVTSLS--CDSHRS 1179

  Fly  1461 DVILAGCDDGSVRLFDKRCAPQDAGISVYRRHSAPILHASL--RANGLVLVSGCTEGRISVADMR 1523
             :|:||..|||:|::|:|.|..:..:..||.|:|.::.|||  |.:|.: ||....|.:.:.|.|
Human  1180 -LIVAGLGDGSIRVYDRRMALSECRVMTYREHTAWVVKASLQKRPDGHI-VSVSVNGDVRIFDPR 1242

  Fly  1524 GSQSSINPFDVVYEWDAGGDVTAITSHQLEDTVACGNASKI-VIYSLDGRQQKVLRTNEGFIGPK 1587
             ...|:|...:|      ..:||:..|...|.:|||:.::. .||:..|.....::..:||:|.:
Human  1243 -MPESVNVLQIV------KGLTALDIHPQADLIACGSVNQFTAIYNSSGELINNIKYYDGFMGQR 1300

  Fly  1588 IGHPTYLYFHPYKAQLAVGFVDNTVAIYS 1616
            :|..:.|.|||:...||||..|..:::||
Human  1301 VGAISCLAFHPHWPHLAVGSNDYYISVYS 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raptor	NP_001284924.1	Raptor_N	219..365	CDD:291222	112/145 (77%)
		HEAT repeat	612..634	CDD:293787	20/21 (95%)
		HEAT repeat	646..684	CDD:293787	33/37 (89%)
		HEAT repeat	694..724	CDD:293787	16/29 (55%)
		HEAT repeat	734..760	CDD:293787	18/25 (72%)
		HEAT_2	743..847	CDD:290374	60/103 (58%)
		HEAT repeat	774..803	CDD:293787	23/28 (82%)
		HEAT repeat	822..848	CDD:293787	12/25 (48%)
		WD40	<1296..1617	CDD:225201	99/324 (31%)
		WD40	1400..>1617	CDD:295369	75/220 (34%)
		WD40 repeat	1448..1489	CDD:293791	14/40 (35%)
		WD40 repeat	1496..1539	CDD:293791	13/44 (30%)
		WD40 repeat	1544..1581	CDD:293791	10/37 (27%)
		WD40 repeat	1588..1615	CDD:293791	10/26 (38%)
RPTOR	NP_065812.1	Raptor_N	55..206	CDD:405260	116/150 (77%)
		HEAT repeat	516..544	CDD:293787	16/27 (59%)
		HEAT repeat	563..592	CDD:293787	20/28 (71%)
		HEAT_2	566..668	CDD:404525	60/103 (58%)
		HEAT repeat	602..633	CDD:293787	21/30 (70%)
		HEAT repeat	642..669	CDD:293787	12/27 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	850..943		26/126 (21%)
		WD 1	1020..1061		12/65 (18%)
		WD40	1027..1322	CDD:421866	109/384 (28%)
		WD40 repeat	1027..1063	CDD:293791	11/60 (18%)
		WD 2	1065..1106		18/63 (29%)
		WD40 repeat	1069..1121	CDD:293791	22/59 (37%)
		WD 3	1121..1160		16/65 (25%)
		WD40 repeat	1126..1162	CDD:293791	15/36 (42%)
		WD 4	1164..1203		16/42 (38%)
		WD40 repeat	1170..1207	CDD:293791	14/39 (36%)
		WD 5	1209..1249		13/41 (32%)
		WD40 repeat	1214..1252	CDD:293791	12/39 (31%)
		WD 6	1251..1291		11/45 (24%)
		WD40 repeat	1256..1294	CDD:293791	10/37 (27%)
		WD 7	1299..1335		12/31 (39%)
		WD40 repeat	1301..1328	CDD:293791	10/26 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160399
Domainoid	1	1.000	265	1.000	Domainoid score	I1915
eggNOG	1	0.900	-	-		E1_KOG1517
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80210
Inparanoid	1	1.050	1042	1.000	Inparanoid score	I267
Isobase	1	0.950	-	0	Normalized mean entropy	S2708
OMA	1	1.010	-	-		QHG55294
OrthoDB	1	1.010	-	-		D29632at33208
OrthoFinder	1	1.000	-	-		FOG0004448
OrthoInspector	1	1.000	-	-		oto90124
orthoMCL	1	0.900	-	-		OOG6_101923
Panther	1	1.100	-	-	LDO	PTHR12848
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R717
SonicParanoid	1	1.000	-	-		X3153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750