DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment raptor and rptor

DIOPT Version :9

Sequence 1:	NP_001284924.1	Gene:	raptor / 31543	FlyBaseID:	FBgn0029840	Length:	1621	Species:	Drosophila melanogaster
Sequence 2:	XP_005157410.1	Gene:	rptor / 560455	ZFINID:	ZDB-GENE-130530-685	Length:	1363	Species:	Danio rerio

Alignment Length:	1520	Identity:	640/1520 - (42%)
Similarity:	858/1520 - (56%)	Gaps:	246/1520 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 PARSLCFGERI--RDDRCPLSLQTKRHKERIQAMMYERQPWRIRERMKTASVALVLCLNIGVDPP 232
            |...|...|.:  .|...||:...|||.|:|:......|.||:::||||.|||||||||:|||||
Zfish    11 PVLGLAEEEEVDMTDWNLPLAFMKKRHTEKIEGYKALAQSWRMKDRMKTVSVALVLCLNVGVDPP 75

  Fly   233 DVVKIQPCSRLECWIDPSSVSPPKAMELIGSNLQMQYERWQPRARYKKCNDPTVDDVKKLCTSLR 297
            ||||..||:||||||||.|:||.||:|.||:|||.|||.||||||||:..|||||:|||||||||
Zfish    76 DVVKTSPCARLECWIDPLSMSPQKALETIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLR 140

  Fly   298 RNAKGERILFHYNGHGVPKPTANGEIWVFNKTFTQYIPLSIFELITWMSAPSIYVYDCSNAGIII 362
            ||||.||:||||||||||:||.|||||||||.:|||||||:::|.|||.:|||:||||||||||:
Zfish   141 RNAKEERVLFHYNGHGVPRPTVNGEIWVFNKNYTQYIPLSVYDLQTWMGSPSIFVYDCSNAGIIV 205

  Fly   363 NSFQPYAKQHEEELGKALAAAQQRGGVQQLVGGSGGAANVAANQVQLTNQM---VSYKNCIHLAA 424
            .||:.:|.|.|:||..|                       |.|......||   .|.||||.|||
Zfish   206 KSFKQFALQREQELEVA-----------------------AINPNHPLAQMPLPPSMKNCIQLAA 247

  Fly   425 CAANEILPMNAQLPADLFTSCLTTPINIALKWYAMQEKLGMVPRIQSELIDKIPGKVNDRRTMMG 489
            |.|:|:||||..||||||||||||||.|||:|:.||:...:||.:..:||:||||::|||||.:|
Zfish   248 CDASELLPMNPDLPADLFTSCLTTPIKIALRWFCMQKSAKLVPGVTLDLIEKIPGRLNDRRTPLG 312

  Fly   490 ELNWIFTAITDTIAWNTLPRELFQRLFRQDLLVASLFRNFLLAERILRSHDCTPVSLPALPPCYR 554
            ||||||||||||||||.|||:|||:|||||||||||||||||||||:||::|||||.|.|||.|.
Zfish   313 ELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNFLLAERIMRSYNCTPVSSPRLPPTYM 377

  Fly   555 HPMWKAWDLVVDLALQQLPEILDHNAPYRQLPFFEHQLTAFQVWLDSESESRTPPEQLPIVLQVL 619
            |.||:||||.||:.|.|||.|::....:|..|||..|||||||||....|:|.||||||||||||
Zfish   378 HAMWQAWDLAVDICLSQLPTIIEEGTAFRHSPFFAEQLTAFQVWLSMGVENRNPPEQLPIVLQVL 442

  Fly   620 LSQVHRLRALELLARFLDLGPWAVNLALGVGIFPYVLKLLQSSTRELRPVLVFIWAKILAVDPSC 684
            ||||||||||:||.||||||||||:|||.||||||||||||||.|||||:||||||||||||.||
Zfish   443 LSQVHRLRALDLLGRFLDLGPWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSC 507

  Fly   685 QVDLVKE--YKYFLSVLQDTSVSKEHRTLSAFVLSSIVHNFLLGQTSALQGPLLSICLEQLNDGS 747
            |.||||:  :|||||||.|..:..||||::.|:|:.||:|:..||.:.|||.|::||||||||..
Zfish   508 QADLVKDNGHKYFLSVLADPFMPAEHRTMAVFILAVIVNNYNTGQEACLQGNLIAICLEQLNDPH 572

  Fly   748 WLLRQWLAICLGMLWQNFEKARWSGARDLAHEKLYVLLRDSIPEVRAAAVFALGTFISSVTDRSE 812
            .|||||:|||||.:|||::.|||.|.||.||||||.||.|||||||.|||||||||:.:..:|:
Zfish   573 PLLRQWVAICLGRIWQNYDSARWCGVRDSAHEKLYSLLSDSIPEVRCAAVFALGTFVGNSAERT- 636

  Fly   813 EQANNIDRIIAITMLETVGEDMSPLVRMELAAALQWMVVLFESQF--VAVYLTEHMRGHVSAASF 875
            :.:..||..:|: ||..:..|.||:||.||..||..:||.:||.|  ||:...|..:.:.
Zfish   637 DHSTTIDHNVAM-MLAQLINDGSPIVRKELVVALSHLVVQYESNFCTVALQFMEEEKNYA----- 695

  Fly   876 VMCPDPRDLTSS---THSLERHVTIRRGASSSSISNMGGASISSGTGSSSNPLGRSKSG---SGS 934
              .|.|.:.|.:   |.|.: ...|.|..|.:|.:|:..|:.:.....|...|..::.|   :.|
Zfish   696 --VPSPANSTETGNITPSRD-SPAIPRLRSVNSYTNLRAATTARTLNKSLQNLNLNEEGGPAAFS 757

  Fly   935 SGGRGAAGAAGGT----------------------------NS---IPFQSIFTKLWLGICNLAQ 968
            .|....:.:|..|                            ||   :.|.|::|::|..:.:||.
Zfish   758 PGNLSTSSSASSTLGSPDNDEYLLSFETIDKMRRVSSYSSLNSLIGVSFNSVYTQIWRVLLHLAA 822

  Fly   969 DPFPRVAAIAQEIVEHVRDTALCPIMAAKEATMANASEK---CSSLSVSLPPSPNTRVNYLGGGG 1030
            ||||.|:.:|.:::..:          |.:|||...:::   ..||:.|.|.||.::...:...|
Zfish   823 DPFPDVSDLAMKVLNSI----------AYKATMNARTQRILDSGSLTQSAPASPTSKGTLIHQAG 877

  Fly  1031 APG----GAGATAESPPVGAAASGASHWAQKLRLSGSGACMGAGDPQTILQRKLRTSSINDETDS 1091
            |..    .:..::.|||:..|:|.:                        |..::....:.|...:
Zfish   878 ASHRSKCSSSPSSGSPPMPGASSSS------------------------LTNEVPKPPVRDGPSA 918

  Fly  1092 GPGYSRGVAGAG--------TGLGLPSGPRESTHSARSSGSESNHYLEPGHSLTPIVL-TEFIPW 1147
            .|.|:..:.|..        |......||.::.    ..|.|:..:    .|...:.| |....|
Zfish   919 RPPYTPTLGGQAPHSQQFPRTRKMFDKGPDQTA----EDGDETAVH----RSFVSLSLQTGLCDW 975

  Fly  1148 AISYFTRPGKERYSSAEGSAEEGRQRFPVDRNS-AELRR-RRLRFLRNDFVRRHAGRKHQELIDP 1210
            :..||.:|               ..:.|.:.:| :::|: |..|||||..||:.:.|..|..:.
Zfish   976 SAKYFAQP---------------VMKIPEEHDSESQVRKDREWRFLRNARVRKQSQRITQRGVT- 1024

  Fly  1211 YGFDVCVWNRKTQFTPSIVKLLPYEPQIAVAYREKVLVYDFQYNSVRTYGAESLGGNFTGYSSGY 1275
             ..|..::..:....||:||..|:.|.||||.::.:..:|::
Zfish  1025 -RLDDQIFINRNPGVPSVVKFHPFNPCIAVADKDSICFWDWE----------------------- 1065

  Fly  1276 GSGSGSSSSLNGSTPRKSGAHTSGGGGGGFSAAPFARVSSIEFINAQDMALNLVAHEDGVVRVWQ 1340
             .|.......||: ||                  :.|::::|::|..|.:|.|.|.:||.:|:|:
Zfish  1066 -KGERLDYFYNGN-PR------------------YTRITAMEYLNGHDCSLLLTATDDGALRIWK 1110

  Fly  1341 SSPPASSATSEDTPSKARLVTAWTALGQVNQHNHRQRSVASGGSIGKGADASGLSSAAIGSGGIV 1405
                  :...:..|   .:||||..|..:..   ..|.:|...||       .|..:..|..|:|
Zfish  1111 ------NFADQRNP---EMVTAWQGLSDMLP---TTRGLARRVSI-------YLDRSKQGGAGMV 1156

  Fly  1406 TAWQQCSQHLVIGGGGCRFIRIWDVERELKLADIPLGRSETCARVLSPYLPNMRSDVILAGCDDG 1470
            ..|:| ...|::..|..|.|||||.|||:|:.|||.| :::|...||   .:.:..::.||..||
Zfish  1157 VDWEQ-ETGLLMTSGDVRVIRIWDTEREIKVQDIPTG-ADSCVTSLS---CDPQRSLVAAGLGDG 1216

  Fly  1471 SVRLFDKRCAPQDAGISVYRRHSAPILHASLRANGLVLVSGCTEGRISVADMRGS--------QS 1527
            |||::|:|..|.:..:..||.|.|.::.|.|:..        .||.|....:.|.        ..
Zfish  1217 SVRVYDRRMGPNECRVMTYREHGAWVVKAHLQKE--------PEGHIISVSVNGDVRFFDPRMPE 1273

  Fly  1528 SINPFDVVYEWDAGGDVTAITSHQLEDTVACGNASK-IVIYSLDGRQQKVLRTNEGFIGPKIGHP 1591
            |:|....|      ..:||:..|...:..|||:.:: |.:::.:|.....::..:||:|.:||..
Zfish  1274 SVNTLQTV------KGLTALDIHPQANLFACGSMNQFIAVHNSNGDVISNIKYYDGFMGQRIGAI 1332

  Fly  1592 TYLYFHPYKAQLAVGFVDNTVAIYS 1616
            :.|.|||:...||||..|..::|||
Zfish  1333 SCLAFHPFWPHLAVGSNDYYMSIYS 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
raptor	NP_001284924.1	Raptor_N	219..365	CDD:291222	114/145 (79%)
		HEAT repeat	612..634	CDD:293787	20/21 (95%)
		HEAT repeat	646..684	CDD:293787	33/37 (89%)
		HEAT repeat	694..724	CDD:293787	16/29 (55%)
		HEAT repeat	734..760	CDD:293787	18/25 (72%)
		HEAT_2	743..847	CDD:290374	60/103 (58%)
		HEAT repeat	774..803	CDD:293787	24/28 (86%)
		HEAT repeat	822..848	CDD:293787	12/25 (48%)
		WD40	<1296..1617	CDD:225201	94/330 (28%)
		WD40	1400..>1617	CDD:295369	72/226 (32%)
		WD40 repeat	1448..1489	CDD:293791	12/40 (30%)
		WD40 repeat	1496..1539	CDD:293791	9/50 (18%)
		WD40 repeat	1544..1581	CDD:293791	8/37 (22%)
		WD40 repeat	1588..1615	CDD:293791	11/26 (42%)
rptor	XP_005157410.1	Raptor_N	62..208	CDD:317004	114/145 (79%)
		Adaptin_N	474..>678	CDD:331138	127/205 (62%)
		HEAT repeat	518..546	CDD:293787	15/27 (56%)
		HEAT repeat	559..589	CDD:293787	20/29 (69%)
		HEAT repeat	601..627	CDD:293787	21/25 (84%)
		HEAT repeat	642..672	CDD:293787	14/30 (47%)
		WD40	1040..1350	CDD:330360	105/390 (27%)
		WD40 repeat	1042..1076	CDD:293791	10/57 (18%)
		WD40 repeat	1083..1125	CDD:293791	14/50 (28%)
		WD40 repeat	1155..1188	CDD:293791	15/33 (45%)
		WD40 repeat	1197..1236	CDD:293791	12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596768
Domainoid	1	1.000	268	1.000	Domainoid score	I1825
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80210
Inparanoid	1	1.050	1037	1.000	Inparanoid score	I264
OMA	1	1.010	-	-		QHG55294
OrthoDB	1	1.010	-	-		D29632at33208
OrthoFinder	1	1.000	-	-		FOG0004448
OrthoInspector	1	1.000	-	-		oto40670
orthoMCL	1	0.900	-	-		OOG6_101923
Panther	1	1.100	-	-	LDO	PTHR12848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3153
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910