Protein Alignment raptor and daf-15

DIOPT Version :10

• Sequence 1: NP_572294.2
• Gene: raptor / 31543
• FlyBaseID: FBgn0029840
• Length: 1621
• Species: Drosophila melanogaster
• Sequence 2: NP_001368188.1
• Gene: daf-15 / 177770
• WormBaseID: WBGene00000911
• Length: 1800
• Species: Caenorhabditis elegans
• Alignment Length: 1900
• Identity: 518/1900 - (27%)
• Similarity: 740/1900 - (38%)
• Gaps: 608/1900 - (32%)

  Fly   176 FGERI---------RDDRCPLSLQTKRHKERIQAMMYERQPW----------RIRERMKTASVAL 221
            |.||:         ..:|..|.||..||.|.|...|.:.  |          :..:|::|||||:
 Worm    37 FAERLTVNLWHAQRNVERVTLYLQEPRHVEDIAGSMEDE--WDCIEECVNRRKGSDRLRTASVAI 99

  Fly   222 VLCLNIGVDPPDVV--KIQPCSRLECWIDPSSVSPPKAMELIGSNLQMQYERWQPRA--RYKKCN 282
            ::||::|||||:..  |..| |||..|:||......||...||.:.|..||:|||::  |||.|.
 Worm   100 IMCLHLGVDPPEAPSRKDAP-SRLLSWVDPYKCGAHKAAIEIGLSTQRAYEKWQPKSKTRYKICT 163

  Fly   283 DPTVDDVKKLCTSLRRNAKGERILFHYNGHGVPKPTANGEIWVFNKTFTQYIPLSIFELITWMSA 347
            ||.:|||:|:.|:|||.:..:|:|||||||||||||.|||||||||:||||||||||:|..|:..
 Worm   164 DPPIDDVRKVATNLRRISGNDRVLFHYNGHGVPKPTDNGEIWVFNKSFTQYIPLSIFDLQGWLDY 228

  Fly   348 PSIYVYDCSNAGIIINSFQPYAK-------------QHEEE----LGKALAAAQQRGGVQQLVGG 395
            |:||:::..:|..|:::::.:.:             |.|:.    :...:..|.|
 Worm   229 PTIYIWETHSAETILHNYRRFGEDQKISWQSRFDRWQEEQRNLPPISSKMTDADQ---------- 283

  Fly   396 SGGAANVAANQVQLTNQMVSYKNCIHLAACAANEILPM-NAQLPADLFTSCLTTPINIALKWY-A 458
                    |..:....:...|.:|||||||:|.:.||| |..||||||||||||||..:|.:: :
 Worm   284 --------AEALGFPEKYPRYNDCIHLAACSAGQWLPMSNPHLPADLFTSCLTTPIRTSLAFHLS 340

  Fly   459 MQEKLGMVPRIQSELIDKIPGKVNDRRTMMGELNWIFTAITDTIAWNTLPRELFQRLFRQDLLVA 523
            ..|.....|   ..::|.|||.:.:|||::|||||||||||||||:.::.|:.||:|||||||:|
 Worm   341 HSEHRDEYP---ENILDMIPGNLAERRTVLGELNWIFTAITDTIAFTSIDRDSFQKLFRQDLLLA 402

  Fly   524 SLFRNFLLAERILRSHDCTPVSLPALPPCYRHPMWKAWDLVVDLALQQLPE-------------- 574
            :|||:||||:|::...:..|||.|.|.....|.:|:.||..:|:.|....|
 Worm   403 TLFRSFLLAQRVMSKFNVLPVSQPPLKDTSMHDLWRCWDQTMDMVLDYCRELIYVKECERALFCG 467

  Fly   575 --------------------ILDHNAPYRQLPFFEHQLTAFQVWLDSESESRTPPEQLPIVLQVL 619
                                :|.:|..::...||..||.||::|||...:..|||.|||:|||||
 Worm   468 RDVINRSNVFPFLVLIDFEHVLTYNETHQYNTFFTEQLQAFELWLDYGVDEGTPPLQLPMVLQVL 532

  Fly   620 LSQVHRLRALELLARFLDLGPWAVNLALGVGIFPYVLKLLQSSTRELRPVLVFIWAKILAVDPSC 684
            |||.||:|||.|||||||.|.||:..:|.|||||||||||||:..:|:..|.|||||||||||||
 Worm   533 LSQAHRVRALRLLARFLDFGRWAIGYSLAVGIFPYVLKLLQSNISDLKISLAFIWAKILAVDPSC 597

  Fly   685 QVDLVKE---------------------------------------------------------- 691
            |::|..|
 Worm   598 QMELFNECIDESATQQQSPAQSQQPSVALKPSSMFANHPPPAQLTMDKRALQINTQTGGRFQTNQ 662

  Fly   692 ----------------------------------------------------------------- 691
                                                                             
 Worm   663 NQALDMQLQYAQQQAHQRQMDPSGGQHSPNAQPRQPQPQQPQQLQQQPSQQQQQQSRQPQGIMKP 727

  Fly   692 -------------YKYFLSVLQDTSVSKEHRTLSAFVLSSIV-HNFLLGQTSALQGPLLSICLEQ 742
                         ::|||.:|.|..:..:.:|::||||:.:. :||.|.|........:.||.|.
 Worm   728 TNAQPQEKKTMLRFQYFLQLLGDPEIKPKQKTVAAFVLAQLTSNNFKLAQKELTNKGYMGICTEL 792

  Fly   743 LNDGS----WLLRQWLAICLGMLWQNFEKARWSGARDLAHEKLYVLLRDSIPEVRAAAVFALGTF 803
            :.|.:    .||:.|:.|.||.||.:::.|||.|.|.:||:|:.:.|.|...|||||||||||:.
 Worm   793 MVDDTARSVKLLKLWILIGLGRLWSDYDVARWQGIRLMAHDKMILELSDESAEVRAAAVFALGSL 857

  Fly   804 ISSVTDRSEEQANNIDRIIAITMLETVGEDMSPLVRMELAAALQWMVVLFESQFVAVYLTEHMRG 868
            :.: :.||.|.|:.::..:|..:......|.|.|||.||..||||.|..||.:||...|
 Worm   858 LRN-SSRSNEHASAVEENLAGELCSQCVFDSSVLVREELIVALQWFVFDFEKRFVKFLL------ 915

  Fly   869 HVSAASFVMCPDPRDLTSSTHSLERHVTI-------RRGASSSSISNMGGASI---SSGTGSSSN 923
              ..::.:....||...||.:..|:.:.|       .|...:..::.....|:   ...|...|.
 Worm   916 --ELSNQIKFKLPRKRNSSENLSEQGLDIAAEMPSNHRRPRAPPVNEFMQPSVIRKKMSTSVFST 978

  Fly   924 PLGRSKSGSGSSGGRGAAGAAGG---------------------TNSIPFQSIFTKLWLGICNLA 967
            .:..:....|.......|..||.                     ..:..|.....|.||.:..|:
 Worm   979 AVEETVHEDGIGNVYHIAHEAGNRVEQESEDIEYRERAKVQIKHLEAKTFNEAVAKTWLSLLILS 1043

  Fly   968 QDPFPRVAAIAQEIVEHVRDTALCPIMAAK-EATMANASEKC-----SSLSVSLPPSPNTRVNYL 1026
            .||..|||.:||:||..|.  |..|.|.|. :.|||:.|.|.     |..:|.:|..|
 Worm  1044 LDPIERVARMAQKIVHRVE--AGMPEMQANIDNTMAHLSRKMIARKNSKATVEMPRKP------- 1099

  Fly  1027 GGGGAPGGAGATAESPPV--------------GAAASGAS------HWAQKLRLSGSGACM---- 1067
                    .|.:.|...:              |.:|.|..      ..|::.|..|.|..:
 Worm  1100 --------VGPSEEVSTLSERIKRNLEVEKESGVSADGIDFTKLNMQKAKEQRKGGKGGQIKKLQ 1156

  Fly  1068 -------GAGDPQTILQRKLRT----SSINDETDSGPGYS----------------RGVAGAGTG 1105
                   ..|.|..:.|:....    ||..|||.|...:|                :..|...:|
 Worm  1157 DESKVKFQVGSPGDVNQQHKNALSPGSSFTDETQSSELFSKDDSSDDDENKSANDEKDRATTASG 1221

  Fly  1106 LGLPSGPRES--------THSARSSGSESNHYLEPGHSLT-------PIVLTEFIPWAISYFTRP 1155
            ..:....|:|        ..:.|.:.:....:.....|.|       |||.|:|:.|....|..|
 Worm  1222 KTVKGAFRKSDIMDAALMEFTPRRTKAVPGDFAVKEESKTLRTVIENPIVSTQFVAWCSKVFVEP 1286

  Fly  1156 -------------GKERYSSAEGSAEEGRQRF----PVDRNSAELRRRRLRFLRNDFVRRHAGRK 1203
                         ..|.....|...|:.|::.    ..||...|.:|.|         .:..|:|
 Worm  1287 ILHVITLDEEKSEDWEHEDEDEFMPEQFREKIKDIQKQDRKMHEEKRAR---------DKKEGKK 1342

  Fly  1204 HQ------------------------ELIDPYG-------FDVCVWNRK-----TQFTPSIVKLL 1232
            .:                        :..|..|       :|.|:|..|     ...|.|.::..
 Worm  1343 EKSQEDVVVTTTTISDWAIHAMEGMLQSADIEGRDFQSCKYDECLWRVKLTHPARSLTTSKLRRC 1407

  Fly  1233 PY--EPQIAVAYREKVLVYDFQYNSVRTYGAESLGGNFTGYSSGYGSGSGSSSSLNGSTPRKSGA 1295
            .|  :.::....|:     |....|.|.:                        .|..|.|
 Worm  1408 MYASDGRLMTIIRQ-----DTDTRSFRRF------------------------DLTASNP----- 1438

  Fly  1296 HTSGGGGGGFSAAPFARVSSIEFINAQDMALNLVAHEDGVVRVWQSSPPASSATSEDTPSKARLV 1360
                       ..| :.||.:..||.....:.:....:||||:|.   |......:|......||
 Worm  1439 -----------FCP-SYVSQLILINDMSREMVIACSTNGVVRIWD---PYFLGWCDDYEKPPELV 1488

  Fly  1361 TAWTAL-GQVNQHNHRQRSVASGGSIGKGADASGLSSAAIGSGGIVTAWQQCSQHLVIGGGGCRF 1424
            :|...| .|:...:...|.:..                          |.|.:..|:.  .|.|.
 Worm  1489 SASFPLESQMKISDETNRCLFD--------------------------WNQQNGKLLC--TGTRS 1525

  Fly  1425 IRIWDVERELKLADI---PLGRSET--CARVLSPYLPNMRS-------DVILAGCDDGSVRLFDK 1477
            :||||...|....|:   |..:.:|  .|::.:..||...|       :::..|..||.|..||.
 Worm  1526 VRIWDAHCEKVCHDVMYSPGSKQQTGPGAKLNTNTLPTAMSGNLDEEGNMVAVGYADGRVDYFDM 1590

  Fly  1478 RCAPQDAGISVYRRHSAP-------------ILHASLRAN----GLVLVSGCTEGRISVADMRGS 1525
            |.|...|.    |.:.||             |:|  ||.|    |..|.:|..:|.|....:|..
 Worm  1591 RMANPKAA----RCNLAPVNMSKQFNDRPPGIMH--LRVNRQGFGTELFAGSQDGSIYKLQLRMF 1649

  Fly  1526 QSSINPFDVVYEWDAGGDVTAITSHQL--EDT--VACGNASKIVIYSLDGRQQKVLR-------- 1578
            :.: .| .:|..|:.|..     ||..  ||:  :|.....::.||  |..|.|::.
 Worm  1650 KEA-TP-SIVTPWEYGAH-----SHMFVHEDSRILASAGGGELAIY--DVAQNKLMARILPPGEP 1705

  Fly  1579 ------TNEGFIG------------------------------PKIGHPTYLYFHPYKAQLAVGF 1607
                  .|....|                              ||:   ..|..|..:.....|:
 Worm  1706 NSMRRDKNSSTFGLFSSQRKLSQVQMSGRMSSMSSATVGEDRQPKV---ISLTMHQMRLLTVAGY 1767

  Fly  1608 VDNTVAIY-SPTPVL 1621
            .||||.:| ||.|.|
 Worm  1768 DDNTVCVYGSPKPGL 1782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
raptor	NP_572294.2	Raptor_N	214..365	CDD:464202	84/154 (55%)
		HEAT repeat	612..634	CDD:293787	17/21 (81%)
		HEAT repeat	646..684	CDD:293787	27/37 (73%)
		HEAT repeat	694..724	CDD:293787	11/30 (37%)
		HEAT	<725..846	CDD:441023	47/124 (38%)
		HEAT repeat	734..760	CDD:293787	9/29 (31%)
		HEAT repeat	774..803	CDD:293787	17/28 (61%)
		HEAT repeat	822..848	CDD:293787	10/25 (40%)
		WD40	1400..>1617	CDD:475233	66/294 (22%)
		WD40 repeat	1448..1489	CDD:293791	13/47 (28%)
		WD40 repeat	1496..1539	CDD:293791	13/46 (28%)
		WD40 repeat	1544..1581	CDD:293791	10/54 (19%)
		WD40 repeat	1588..1615	CDD:293791	7/26 (27%)
daf-15	NP_001368188.1	Raptor_N	92..246	CDD:464202	84/154 (55%)
		HEAT repeat	834..866	CDD:293787	16/32 (50%)
		HEAT repeat	875..901	CDD:293787	10/25 (40%)
		WD40 repeat	1438..1495	CDD:293791	16/76 (21%)
		WD40 repeat	1568..1604	CDD:293791	10/39 (26%)
		WD40 repeat	1618..1642	CDD:293791	9/25 (36%)