DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4666 and THEM6

DIOPT Version :9

Sequence 1:	NP_001284923.1	Gene:	CG4666 / 31541	FlyBaseID:	FBgn0029838	Length:	193	Species:	Drosophila melanogaster
Sequence 2:	NP_057731.1	Gene:	THEM6 / 51337	HGNCID:	29656	Length:	208	Species:	Homo sapiens

Alignment Length:	203	Identity:	76/203 - (37%)
Similarity:	108/203 - (53%)	Gaps:	23/203 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LVVLLIL----YVIWDVNYFIRCVFTVFAGRLFQ-RKRKVTDTTTIYGLCTSQDVDIFIRHMNNA 63
            ||.||.|    :.:.||.|.:|....|...||.| |.|.:.......|.....|:|:.: |||||
Human     5 LVALLALGLAVFALLDVWYLVRLPCAVLRARLLQPRVRDLLAEQRFPGRVLPSDLDLLL-HMNNA 68

  Fly    64 RYLRELDFARFHFYALTGLYERIRDRRGGAVQGASSVRYRRTIPIFHPYKIQTKLIWWDDKAIYL 128
            |||||.||||.......|:...:|:.|...|..||..|:||::.:..|::::|:|:.|||:|.||
Human    69 RYLREADFARVAHLTRCGVLGALRELRAHTVLAASCARHRRSLRLLEPFEVRTRLLGWDDRAFYL 133

  Fly   129 EQQFITLSDGFVRAVAMSKQNITNCNVLEVLKTYPE-----TAQR----PEKPEELKLWLDAIEL 184
            |.:|::|.||||.|:...:|::        |.|.||     ..||    ||.|.:|:.|:...|.
Human   134 EARFVSLRDGFVCALLRFRQHL--------LGTSPERVVQHLCQRRVEPPELPADLQHWISYNEA 190

  Fly   185 SSQKLRKD 192
            |||.||.:
Human   191 SSQLLRME 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4666	NP_001284923.1	4HBT_2	48..179	CDD:404206	53/139 (38%)
THEM6	NP_057731.1	4HBT_2	54..185	CDD:315859	53/139 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147849
Domainoid	1	1.000	92	1.000	Domainoid score	I7612
eggNOG	1	0.900	-	-		E1_KOG4366
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H105296
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59462
OrthoDB	1	1.010	-	-		D1195870at2759
OrthoFinder	1	1.000	-	-		FOG0003421
OrthoInspector	1	1.000	-	-		otm40591
orthoMCL	1	0.900	-	-		OOG6_106004
Panther	1	1.100	-	-	O	PTHR12475
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4781
SonicParanoid	1	1.000	-	-		X2773
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.750