DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5921 and MPDZ

DIOPT Version :9

Sequence 1:NP_727061.2 Gene:CG5921 / 31538 FlyBaseID:FBgn0029835 Length:886 Species:Drosophila melanogaster
Sequence 2:NP_001362342.1 Gene:MPDZ / 8777 HGNCID:7208 Length:2103 Species:Homo sapiens


Alignment Length:1108 Identity:213/1108 - (19%)
Similarity:332/1108 - (29%) Gaps:384/1108 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 STYGFTVRGGREHGTGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVHKEFIQLVAGQDR 146
            |:.|.||...:: |.|..|..:.|||.....| :.|||.||.||        .:..|.:...|.|
Human  1016 SSLGMTVSANKD-GLGMIVRSIIHGGAISRDGRIAIGDCILSIN--------EESTISVTNAQAR 1071

  Fly   147 VTLKVRG-VGM-LPVRDLPEERLSWSVVKLPSVSGTPSE----SSFKG----------ERRGASR 195
            ..|:... :|. :.:..:|.|.|....:.|...||....    ||:.|          |..|...
Human  1072 AMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELPEREEGEGEES 1136

  Fly   196 DIS------------VVLHVAPRTKLGLGICKG---------PEWKPGIFVQFTKDRSVAREAG- 238
            ::.            |.|...|...||:.|..|         .|...|||::...:.|.|.:.| 
Human  1137 ELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGT 1201

  Fly   239 LRPGDQILSVNSIDFSDVLFSEAV-AVMKSSSKLDMVVRT------------------------- 277
            |:|||:|:.|:.:|..|....:|| |:.|:.:.:..:|::                         
Human  1202 LKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSS 1266

  Fly   278 -------------------------AAGCDLFPGESSGY--------NSSASSVTGDQSP----- 304
                                     |..|.:.|...|.:        .||||.::.|...     
Human  1267 TNPFADSLQINADKAPSQSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFG 1331

  Fly   305 -CWADAKSKRLTAVRE----ESGAGGGGCGLSSAPGAG-----------SPNWSQG--------- 344
             .|.:.:.:..|...|    |...|..|.|||.|....           .||.:.|         
Human  1332 YSWKNIRERYGTLTGELHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIAD 1396

  Fly   345 --VEVHKQM-----------------NKTIIKLTENGTSINNTYIASTGGSSVSGSGSTGSGTSG 390
              :|::.|:                 :|..|....|..::|.  :|...|::|....|.......
Human  1397 ELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNKDAVNQ--MAVCPGNAVEPLPSNSENLQN 1459

  Fly   391 RS------------QQSQSN---------------------PSNPSRNSTTMKR-SHLR-PVNSA 420
            :.            :||.|:                     .|:.:.:.::.|. .||. |.:..
Human  1460 KELGYHRFSLYSKPRQSSSHLVYLCSQLIAVQLHLTEPTVTTSDAAVDLSSFKNVQHLELPKDQG 1524

  Fly   421 GSGIGLSSGSAGSAGSAGSSGSGSRSGGVIAPAPAPPPPAMNEGANASGS----------VGSSL 475
            |.||.:|.....|              |||..:......|..:|....|.          ||..:
Human  1525 GLGIAISEEDTLS--------------GVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPI 1575

  Fly   476 SSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNVDRQ--------LTGHNGNGGHRSSVGQ-- 530
            ...|: .||..|...:...|.:            |.|.|        .:|...|......|.|  
Human  1576 EKFIS-LLKTAKMTVKLTIHAE------------NPDSQAVPSAAGAASGEKKNSSQSLMVPQSG 1627

  Fly   531 ------VSHRQRANVAGVAAT-------LQGSE---RISNLTGGGGAGGAGGSNGAAGA------ 573
                  :.:..|::...:.|:       :.|.|   .||....|.|....|||:...||      
Human  1628 SPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEV 1692

  Fly   574 -------------GGDQ-------------HTALMDEFKRAHQR----MFRNGFHESEHKLSSLG 608
                         .|||             |...::..::..||    ::|:.....|.::....
Human  1693 YEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEVCDTL 1757

  Fly   609 KSSLADRSLYGREMSLLRVKN-----------GGSGGGEGSGVMPTMRPVSMGRPLVTMSTYQER 662
            ...|..:...|..:|::..:|           ||....:|. :|...:.:.:....|..:|.:..
Human  1758 TIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGR-LMQGDQILMVNGEDVRNATQEAV 1821

  Fly   663 GETLK-----------RTSIMPDESCYRNSINSNNN-----------NGFSRNRSNSNTNNNNRL 705
            ...||           |....|..|..|.|.:|..:           :|.|.:.|..:::..|.|
Human  1822 AALLKCSLGTVTLEVGRIKAGPFHSERRPSQSSQVSEGSLSSFTFPLSGSSTSESLESSSKKNAL 1886

  Fly   706 QSQ----------------NGVNPANGNGSPELPPPPPQFANPQPKQMPPQHIKPMTG------- 747
            .|:                .|::.|.|.||| |...|...|...|..:..|..|...|       
Human  1887 ASEIQGLRTVEMKKGPTDSLGISIAGGVGSP-LGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTIC 1950

  Fly   748 -------------NAAANGSGS--ANGLGNGSLAKVRQPMSPMRSASISVGGFRPPATPQPDYDA 797
                         |...|.|||  ...:..|.::.|........|:|:|..|....:..|.|...
Human  1951 GTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDVSVVTGHQQEPASSSLSFTGLTSSSIFQDDLGP 2015

  Fly   798 VQIRSSQGSESVSGRDVATSQQQRRTLRLGTVTIGEYGDQRTTGKRETLRKT---NGEPASNGIL 859
            .|.:|........|              ||...:|.||...  |......||   .|..:.:|.|
Human  2016 PQCKSITLERGPDG--------------LGFSIVGGYGSPH--GDLPIYVKTVFAKGAASEDGRL 2064

  Fly   860 KNG 862
            |.|
Human  2065 KRG 2067

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5921NP_727061.2 PDZ_signaling 82..152 CDD:238492 22/69 (32%)
PDZ_signaling 197..276 CDD:238492 26/101 (26%)
MPDZNP_001362342.1 PDZ_signaling 2019..2102 CDD:238492 15/65 (23%)
L27_2 6..63 CDD:312549
PDZ_signaling 139..221 CDD:238492
PDZ_signaling 257..334 CDD:238492
PDZ 374..463 CDD:214570
PDZ_signaling 560..629 CDD:238492
PDZ_signaling 698..784 CDD:238492
PDZ_signaling 1006..1076 CDD:238492 22/68 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1121..1140 2/18 (11%)
PDZ_signaling 1149..1240 CDD:238492 26/90 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1278..1324 8/45 (18%)
PDZ 1347..1433 CDD:214570 15/85 (18%)
PDZ_signaling 1514..1593 CDD:238492 20/93 (22%)
MPDZ_u10 1595..1659 CDD:374710 9/75 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1600..1645 6/44 (14%)
PDZ 1660..1744 CDD:214570 16/83 (19%)
PDZ_signaling 1758..1836 CDD:238492 12/78 (15%)
PDZ_signaling 1893..1978 CDD:238492 18/85 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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