DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5921 and LNX1

DIOPT Version :9

Sequence 1:NP_727061.2 Gene:CG5921 / 31538 FlyBaseID:FBgn0029835 Length:886 Species:Drosophila melanogaster
Sequence 2:NP_001119800.1 Gene:LNX1 / 84708 HGNCID:6657 Length:728 Species:Homo sapiens


Alignment Length:330 Identity:81/330 - (24%)
Similarity:123/330 - (37%) Gaps:82/330 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    98 GFFVSHVEHGGEAHLKG-LRIGDQILRINGFRL-----DDAVHKEFIQLVAGQDRVTLKVRGVGM 156
            |.|:.:|..||.|:..| |...|::|.|||..|     :.|.|  .||  |.:.||.|.|.....
Human   405 GVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAH--LIQ--ASERRVHLVVSRQVR 465

  Fly   157 LPVRDLPEERLSWSVVKLPSVSGTPSESSFKGERRGASRDI--SVVLHVA-------PRTKLGLG 212
            ....|:.:| ..|        :...|.|...|||....:.:  ::..|..       |...||:.
Human   466 QRSPDIFQE-AGW--------NSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMT 521

  Fly   213 ICKGP---EWKPGIFVQFTKDRSV-AREAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSSKLDM 273
            :..|.   ||...|:|...:...| :|:..::.||.:|:|:.::.::|..|||||::|.:|. .:
Human   522 VAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSS-SI 585

  Fly   274 VVRTAAGCDLFPGE--------SSGYNSSASSVTGDQSPCWA-------------DAKSKRLTAV 317
            |::.....:..|.|        .|.:|.:..|   |.||.|.             |...:|.|| 
Human   586 VLKALEVKEYEPQEDCSSPAALDSNHNMAPPS---DWSPSWVMWLELPRCLYNCKDIVLRRNTA- 646

  Fly   318 REESGAGGGGCGLSSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGTSINN-------TYIASTGG 375
                    |..|....         .|.|.:.......||....||...|       ..:.:..|
Human   647 --------GSLGFCIV---------GGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNG 694

  Fly   376 SSVSG 380
            .|.||
Human   695 RSTSG 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5921NP_727061.2 PDZ_signaling 82..152 CDD:238492 22/59 (37%)
PDZ_signaling 197..276 CDD:238492 24/91 (26%)
LNX1NP_001119800.1 mRING-HC-C3HC3D_LNX1 38..79 CDD:319693
modified RING-HC finger (C3HC3D-type) 41..78 CDD:319693
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 178..214
NPXY motif 181..184
Interaction with MAGEB18. /evidence=ECO:0000269|PubMed:20864041 186..244
PDZ_signaling 272..355 CDD:238492
PDZ_signaling 380..460 CDD:238492 22/58 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..494 6/26 (23%)
PDZ_signaling 505..588 CDD:238492 23/83 (28%)
PDZ_signaling 637..721 CDD:238492 17/81 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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