DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Pard3

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_112514.1	Gene:	Pard3 / 81918	RGDID:	620374	Length:	1337	Species:	Rattus norvegicus

Alignment Length:	850	Identity:	168/850 - (19%)
Similarity:	275/850 - (32%)	Gaps:	219/850 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SSMQGSTTSSASSDVMTLTTTAASSWCA--IPASSRLRVLRLVRPHQRRLLVGGPERGST-YGFT 88
            |.||....:.|..:.:.||......:..  :|.:                     :.||. .|.:
  Rat   561 SQMQSPKETKAEDEDIVLTPDGTREFLTFEVPLN---------------------DSGSAGLGVS 604

  Fly    89 VRGGR---EHG-TGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVHKE------------ 136
            |:|.|   .|. .|.||..:.:||.|...| ||:.||::.:||..|....::|
  Rat   605 VKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTE 669

  Fly   137 -----FIQLVAGQDRVTL--KVRGVGMLPVRDLP--------EERLSWSVVK-LPSVSGTPSESS 185
                 .|||:..: |::.  ::|..|.....:||        |.|:|.|:.. :..:..:|:.::
  Rat   670 GNKRGMIQLIVAR-RISRCNELRSPGSPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNA 733

  Fly   186 FKGERRGAS------------RDISVVL----------HVAPRTK------LGLGICKGPEWKPG 222
            ......|.|            .|.:|::          |::.::.      :|..:.:...|...
  Rat   734 ALSRIMGESGKCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSSSSHDDVGFIMTEAGTWAKA 798

  Fly   223 IFVQFTKDRSVAREAGLRPG-DQILSVNSIDFSDVLFSE-AVAVMKSSSKLDMV-VRTAAGCDLF 284
            ..       |.:.:..|.|. |.:|:.....|.....|| ......::|:||.| .|.:...||.
  Rat   799 TI-------SDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSNASQLDFVKTRKSKSMDLG 856

  Fly   285 PGESSGYNS----SASSVTGDQSPCWADAKSKRL----TAVREESGAG-------------GGGC 328
            ..:.:..|:    .|.|...|..|.....||..|    |||.|.:..|             |.||
  Rat   857 IADETKLNTVDDQRAGSPNRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRGC 921

  Fly   329 GLSSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGTSINNTYIASTGGSSVSG--SGSTGSGTSGR 391
                       |.|....:.|..:|.::...:.|.   .|....|..||.||  |.||.|.....
  Rat   922 -----------NESFRAAIDKSYDKPMVDDDDEGM---ETLEEDTEESSRSGRESVSTSSDQPSY 972

  Fly   392 SQQSQSNPSNPSRNSTTMKRSHLRPVNSAGSG-----------IGLSSGSAGSAGSAGSSGSGSR 445
            |.:.|.|.....|:....|:      :.||..           :....|.....|.....|...:
  Rat   973 SLERQMNGDPEKRDKAEKKK------DKAGKDKKKDREKEKDKLKAKKGMLKGLGDMFRFGKHRK 1031

  Fly   446 SGGVIAPAPAPPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRD---RDRD- 506
                            ::.....|.:....|....|:..:.||:|::.|.:.|..|:   |:||
  Rat  1032 ----------------DDKMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQARERDY 1080

  Fly   507 --------GNGNVDRQLTGHNGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGG 563
                    ..|..|..|.|  |...:...:...:..|......:..||....:...      :..
  Rat  1081 AEIQDFHRTFGCDDELLYG--GMSSYDGCLALNARPQSPREGHLMDTLYAQVKKPR------SSK 1137

  Fly   564 AGGSNGAAGAGGDQHTALMDEFKRAHQR---MFRNGFHESEHKLSSLGKSSLADRSLYGREMSLL 625
            .|.||.:..:..|:...|..||::|.|.   ..|...:..|...||...:|.:.|.....|:.:.
  Rat  1138 PGDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQSGRHSVSVEVQVQ 1202

  Fly   626 RVKNGGSGGGEGSGVMPTMRPVS-------MGRPLVTMSTYQER---GETLKRTSIMPDESCYRN 680
            |.:.     .|........|..|       .....|:..::::.   ||..:.....|..|.|:.
  Rat  1203 RQRQ-----EERESFQQAQRQYSSLPRQSRKNASSVSQDSWEQNYAPGEGFQSAKENPRYSSYQG 1262

  Fly   681 SINSN-NNNGFSRN--------RSNSNTNNNNRLQSQNGVNPANGNGSP---ELPPPPPQFANPQ 733
            |.|.. ..:||:..        ..........:|:.|   .||:|...|   ::||.|.|.|...
  Rat  1263 SRNGYLGGHGFNARVMLETQELLRQEQRRKEQQLKKQ---PPADGVRGPFRQDVPPSPSQVARLN 1324

  Fly   734 PKQMP 738
            ..|.|
  Rat  1325 RLQTP 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	26/94 (28%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	16/97 (16%)
Pard3	NP_112514.1	DUF3534	1..146	CDD:288873
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..109
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..263
		PDZ_signaling	272..347	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..441
		PDZ_signaling	465..544	CDD:238492
		PDZ_signaling	588..681	CDD:238492	26/113 (23%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000269\|PubMed:9763423	712..936		45/241 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..888		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1015		19/91 (21%)
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1337		84/435 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1055		3/42 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1110..1271		31/171 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1337		12/48 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900