DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5921 and PDZD3

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_011541302.1	Gene:	PDZD3 / 79849	HGNCID:	19891	Length:	571	Species:	Homo sapiens

Alignment Length:	280	Identity:	68/280 - (24%)
Similarity:	105/280 - (37%)	Gaps:	81/280 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MTLTTTAASSWCAIPASSRLRVL-----------RLVRP-----HQRRLLVGGP----------- 79
            :.|:|..|:....:|..:||..:           :|.|.     .|..|||.||
Human   247 LVLSTGGAAERAGVPPGARLLEVNGVSVEKFTHNQLTRKLWQSGQQVTLLVAGPEVEEQCRQLGL 311

  Fly    80 ---------------------ERG-STYGFTVR--GGREHGTGFFVSHVEHGGEAHLKGLRIGDQ 120
                                 |:| ..:||.:|  .|.:...|.|:..|:.|..|...|::.||:
Human   312 PLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDR 376

  Fly   121 ILRINGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSWSVVKLPS---VSGTPS 182
            ::.:.|..::...|:|.:..:.||....       .|.|.| ||....:|:|:|..   :..|.:
Human   377 LVAVAGESVEGLGHEETVSRIQGQGSCV-------SLTVVD-PEADRFFSMVRLSPLLFLENTEA 433

  Fly   183 ESSFKGERRGA---SRDISVVLHVAPRTKLGLGIC---KGPEWK-----------PGIFV-QFTK 229
            .:|.:|....:   :.|.|:.....|...||...|   .||...           |.:|: |.|.
Human   434 PASPRGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTP 498

  Fly   230 DRSVAREAGLRPGDQILSVN 249
            ..|.|| |||:.||.||.||
Human   499 GGSAAR-AGLQVGDVILEVN 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	18/72 (25%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	23/68 (34%)
PDZD3	XP_011541302.1	PDZ_signaling	113..193	CDD:238492
		PDZ_signaling	221..298	CDD:238492	11/50 (22%)
		PDZ	326..411	CDD:214570	22/92 (24%)
		PDZ_signaling	466..545	CDD:238492	19/53 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810