DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Grip1

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	691	Identity:	142/691 - (20%)
Similarity:	253/691 - (36%)	Gaps:	182/691 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGGPERGSTYGFTVR 90
            |.|:..||...|...|.|.||..                         :|...|..|  :|..::
Mouse   507 SLSLASSTVGLAGQVVHTETTEV-------------------------VLTADPVTG--FGIQLQ 544

  Fly    91 GG----REHGTGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVHKEFIQLVAGQ---DRV 147
            |.    ....:...:|::|....|...| |:|||:::.|||...:|:..:|..||:...   .:|
Mouse   545 GSVFATETLSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEANQLLRDSSITSKV 609

  Fly   148 TLKVRGVGMLPVRDLPEERLSWSVVKLPSVSGTPSESSFKGERRGASRDISVVLHVAPRTKLGLG 212
            ||::            |..::.||:        ||..:|           .|.|......:||:.
Mouse   610 TLEI------------EFDVAESVI--------PSSGTF-----------HVKLPKKHSVELGIT 643

  Fly   213 ICKGPEWKPG--IFVQFTKDRSVAREAG-LRPGDQILSVNSIDFSDVLFSEAVAVMKSSSKL-DM 273
            |......|||  :.:...|..|||...| |..||::|::::|...:....:||.:::....| .:
Mouse   644 ISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKL 708

  Fly   274 VVR---------TAAGCDLFPGESSGYNSSAS-SVTGDQSPCWADAKSKRLT--AVREESGA--- 323
            .:|         .::|..::..|...|..... :::|.:.| :.......||  .:.|.:||
Mouse   709 KIRKDEDNSDEQESSGAIIYTVELKRYGGPLGITISGTEEP-FDPIIISSLTKGGLAERTGAIHI 772

  Fly   324 GGGGCGLSSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGTSINNTYIASTGGSSVSG-SGSTGSG 387
            |.....::|:...|.| .|:.:.:.:...:|:....:..|...:.  :|.....:.| ||..|.|
Mouse   773 GDRILAINSSSLKGKP-LSEAIHLLQMAGETVTLKIKKQTDAQSA--SSPKKFPIPGHSGDLGDG 834

  Fly   388 TSGRSQQSQSNPSNPSRNSTTMKRSHLRPVNSAGSGIGLSSGSAGSAGSAGSSGSGSRSGGV--- 449
                    :.:|| |.:....:..::...|.|..|.:....|| |...|.||.||..::.|.
Mouse   835 --------EEDPS-PIQKPGKLSDAYPSTVPSVDSAVDSWDGS-GIDASYGSQGSTFQTSGYNYN 889

  Fly   450 ------------IAPAPAP-----PPPAMN----EGANASGSVGSSLSSAITEELKKRKEKQQQQ 493
                        ::|.|.|     |...::    :.:.|||.||:|.|:          :.:|::
Mouse   890 TYDWRSPKQRTSLSPVPKPRSQTYPDVGLSNEDWDRSTASGFVGASDSA----------DAEQEE 944

  Fly   494 QHQQRHNRDRDRDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGG 558
            ....:...|.:..|...:.|:|        ...:..:||.|   |:..:|..:.||....|
Mouse   945 NFWSQALEDLETCGQSGILREL--------EEKADRRVSLR---NMTLLATIMSGSTMSLN---- 994

  Fly   559 GGAGGAGGSNGAAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMS 623
                               |.|.|...:...|..|:.......| .|...:|:.....:..:.::
Mouse   995 -------------------HEAPMARSQLGRQASFQERSSSRPH-YSQTTRSNTLPSDVGRKSVT 1039

  Fly   624 LLRVKNGGSGGGEGSGVM-PTMRPVSMGRPLVTMSTYQERG 663
            |.::|.      |...:| ||  ||.:.:  ||:  |::.|
Mouse  1040 LRKMKQ------EIKEIMSPT--PVELHK--VTL--YKDSG 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	21/77 (27%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	21/82 (26%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492
		PDZ_signaling	209..292	CDD:238492
		PDZ_signaling	307..390	CDD:238492
		PDZ_signaling	526..614	CDD:238492	25/126 (20%)
		PDZ_signaling	627..711	CDD:238492	22/94 (23%)
		PDZ_signaling	727..808	CDD:238492	15/82 (18%)
		PDZ_signaling	1058..1138	CDD:238492	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900