DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Whrn

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001008791.1	Gene:	Whrn / 73750	MGIID:	2682003	Length:	918	Species:	Mus musculus

Alignment Length:	816	Identity:	173/816 - (21%)
Similarity:	268/816 - (32%)	Gaps:	291/816 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SWCAI----PASSRLRVLRLVRPHQRRLLVGGPERGSTYGFTVRGGREHGTGFFVSHVEHGGEAH 111
            :|.|.    |...||..||..:.|:            ..||::|||.|||.|.:||.||.|..|.
Mouse   127 AWAAPDGAGPGEVRLVSLRRAKAHE------------GLGFSIRGGSEHGVGIYVSLVEPGSLAE 179

  Fly   112 LKGLRIGDQILRINGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSW-----SV 171
            .:|||:||||||:|...|....|.|.::.:.|..::.|.|...|.:|...:.....:|     ..
Mouse   180 KEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRS 244

  Fly   172 VKLPSVSGTPSESSFK---GERR--------GASRDISVVLHVAPRTKLGLGICKGPEWKPGIFV 225
            ...||....|..|:.:   .:||        |..:.:::||  .....|||.|..|.|:..||::
Mouse   245 TSPPSSLPQPHGSTLRQREDDRRSTLHLLQSGDEKKVNLVL--GDGRSLGLTIRGGAEYGLGIYI 307

  Fly   226 QFTKDRSVAREAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVR-------------- 276
            ......|.|..:||:.|||||.||...|.::|..|||.::|||..|.:.|:
Mouse   308 TGVDPGSEAESSGLKVGDQILEVNGRSFLNILHDEAVKLLKSSRHLILTVKDVGRLPHARTTVDQ 372

  Fly   277 --------------TAAGCDLFPGESSGYNSS---------ASSVT----GDQSPCWADAKSKRL 314
                          .:||   |||:.:...:|         .|.||    |:|:....|.:::.|
Mouse   373 TKWIASSRIGESVANSAG---FPGDHTEEGTSKPGFYKGPAGSQVTLSSLGNQTRALLDDQARHL 434

  Fly   315 TAVREESGA-------GGGGCG--------------------LSSAPGAGSPNWSQGVEVHKQMN 352
            ...:|.:..       .||...                    ||......||......: |..:.
Mouse   435 LTEQERATMMYYLAQYRGGTISVEAMVMALFELLNTHAKFSLLSEVRSIISPQDLDRFD-HLVLR 498

  Fly   353 KTIIKLTEN---GTSINNTYIASTGGSSVSGSGSTGSGT------------------------SG 390
            :.|..:...   |..:.:||...:...:.|.:||.|:.|                        :|
Mouse   499 REIESMKARQPPGPGVGDTYSMVSYSDTGSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEGTG 563

  Fly   391 RSQQSQSNP---------SNPSRNSTTMK---------RSHLR--------------PVNSAG-S 422
            .:.|..:|.         .:||.:...:|         :.|.|              |::||. |
Mouse   564 ETTQGSTNALPDVSVDDVKSPSEDLPGIKPPPPPPPLAQGHDRLLGQPRKPGREDPAPLSSAAHS 628

  Fly   423 GIGLS-----SGSAGSAGSAG-SSGSGSRSGGV--------------------------IAPAP- 454
            ||..|     |...|:|.:.| ||...|.|..:                          |.|.|
Mouse   629 GIVFSAPRNRSPPPGTAPTPGPSSAQDSPSSPIYASISHANPSSRKPLDTHLALVNQHPIGPFPR 693

  Fly   455 --APP----PPAMNEGANA----------SGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRDR 503
              :||    |||...||.|          ..:||::....:.|.                |..|.
Mouse   694 VQSPPHLKSPPAETPGAGACLPPPSPSEHPDAVGANQHFVLVEV----------------HRPDS 742

  Fly   504 DRDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSN 568
            :.|                     |.:|....:...|...:.|..|.:..:...|..||
Mouse   743 EPD---------------------VNEVRALPQTRTASTLSQLSDSGQTLSEDSGVDAG------ 780

  Fly   569 GAAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSG 633
                                          |:|...|..|:.:.:.::..|:|..  |.:....|
Mouse   781 ------------------------------ETEASTSGRGRQTASAKNKNGKEQP--RTERTAEG 813

  Fly   634 GGEGSGVM-PTMRPVSMGRPLVTMSTYQERGETLKR 668
            ..:..|:: ||...|.:.:...|:....|.|...::
Mouse   814 ANKPPGLLEPTSTLVRVRKSAATLGIAIEGGANTRQ 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	30/69 (43%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	30/78 (38%)
Whrn	NP_001008791.1	HN_L-whirlin_R1_like	38..113	CDD:259822
		PDZ_signaling	139..216	CDD:238492	34/88 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		4/25 (16%)
		PDZ_signaling	278..358	CDD:238492	30/81 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		6/22 (27%)
		HN_L-whirlin_R2_like	420..500	CDD:259823	12/80 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..538		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..824		57/338 (17%)
		PDZ_signaling	827..898	CDD:238492	4/23 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810