DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Dlg5

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	854	Identity:	165/854 - (19%)
Similarity:	270/854 - (31%)	Gaps:	313/854 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GFFVSHVEHGGEAHLKGLRIGDQILRINGFRLDDAVHKEFIQ-LVAGQDRVTLKVRGVGMLPVRD 161
            |.||:.|:.|..|..: ||:.|.:||||...|.:...|:.|: |:.|:..:.:.||
Mouse   658 GIFVTKVDKGSIADGR-LRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVR--------- 712

  Fly   162 LPEERLSWSVVKLPSVSGTPSESSFKGERRGASRDISVVLHVAPRTKLGLGICKGPEWKPGIFVQ 226
             ..:.|...||       ||...:..|::....:|..:.|                  :.|::..
Mouse   713 -RRKSLGGKVV-------TPLHINLSGQKGSRPQDSGISL------------------ENGVYAA 751

  Fly   227 FTKDRS-VAREAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPGESSG 290
            .....| .|:|..|..||:|:::|.|...:...:|..::::|..  |.:  |.:...:||
Mouse   752 AVVPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQ--DSL--TLSLLKVFP----- 807

  Fly   291 YNSSASSVTGDQSPCWADAK-------SKRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGVEVH 348
                       ||..|:...       |.|:.:.|                 |..|.    |:.|
Mouse   808 -----------QSSSWSGQNIFENIKDSDRMLSCR-----------------AHGPE----VQAH 840

  Fly   349 KQMNKTIIKLTENGTSINNTY---------IASTGGSS------VSGSGSTGS-----GTSGRSQ 393
               ||..:....|.|..:..|         :..:||||      .|||.|..|     .||.||.
Mouse   841 ---NKRNLLQHNNSTQTDIFYTDRLEDRKELGHSGGSSSFLHKPFSGSSSPVSPQACPSTSERSL 902

  Fly   394 QSQSNPSNPSRNSTTMKRSHLRPVNSAGSGIGLSSGSAGSAGSAGSSGSGSRSGGVIAPAPAPPP 458
            .|..:.::..|....:.....||:.|..:.:|                   ..|.|..|.....|
Mouse   903 NSFRSDTSAERGYGLVDMRSQRPLLSFETEVG-------------------PCGAVEVPLDKIDP 948

  Fly   459 PAMNEGANASGSVGSSL--SSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNVDRQLTGHNGN 521
                ||:|:.|:...::  |::..|:|...|:.:|::.....:...|.:. ...:|..|.|
Mouse   949 ----EGSNSGGTWPKAVLGSTSGPEKLSVYKKPKQRKSIFDPNTFKRPQT-PPKIDYLLPG---- 1004

  Fly   522 GGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAGGDQHTALMDEFK 586
                              .|:..:.|.|:|:.:||                  ..:.....|..|
Mouse  1005 ------------------PGLTHSPQPSKRVGSLT------------------PPKPPRRSDSIK 1033

  Fly   587 RAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSL-----------------------LRVK 628
            ..|:                |..||.::.:|.|...|.                       .||:
Mouse  1034 FQHR----------------LETSSESEATLVGSSPSTSPPSAPPPSMDPSEPTHASPPRKARVR 1082

  Fly   629 NGGSGGGEGSG---VMPTMRPVSMGRPLVTMSTYQERGETLKRTSIMP----------------- 673
            ...|...||.|   .:|..:|....   :|.....|.|:..:|....|
Mouse  1083 IASSYHSEGDGDTSYLPAKKPCDED---LTSQKVDELGQKRRRPKSAPSFRPKISPVVIPAQCLE 1144

  Fly   674 DESCYRNSINSNNNNGFSRNRSNSNTNNNNRLQSQNGVNP--ANGNGSPELPPPPPQFANPQPKQ 736
            ::.|. .:|...:..|                |..:..:|  |:.:|:|.|.|..|. ....|:.
Mouse  1145 EQECV-PAIGELSPEG----------------QEWSPYSPGHASRHGNPLLYPNRPS-VGTVPRS 1191

  Fly   737 MPPQHIKPMTGNAAANGSGSANGLGNGSLAKVRQPMSPMRSASISVGGFRPPATPQPDYDAVQIR 801
            |.|                   |...||:  :|.|:..:||..:     .|..:|....||
Mouse  1192 MTP-------------------GTTVGSI--LRNPIYTVRSHRV-----LPCGSPPVPRDA---- 1226

  Fly   802 SSQGSESVSGRDVATSQQQRRTLRLGTVTIGEYGDQRTTGKRETLRKTNGEPASNGILKNGSNRS 866
               ||:|:|   .:...|.|.:|.|......:|.:.|.:                    .|||..
Mouse  1227 ---GSQSLS---PSVQHQGRLSLDLSHRACSDYSEMRAS--------------------QGSNSL 1265

  Fly   867 SASFNHGSS 875
            .:|...|||
Mouse  1266 PSSARLGSS 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	18/54 (33%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	14/79 (18%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117
		PDZ_signaling	625..712	CDD:238492	18/54 (33%)
		PDZ_signaling	<741..800	CDD:238492	14/80 (18%)
		PDZ	1357..1439	CDD:214570
		dbPDZ_assoc	1437..1512	CDD:374667
		PDZ	1513..1594	CDD:214570
		SH3_DLG5	1610..1672	CDD:212794
		GuKc	1744..1920	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900