DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Pdzd2

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_038959013.1	Gene:	Pdzd2 / 65034	RGDID:	619958	Length:	2818	Species:	Rattus norvegicus

Alignment Length:	1002	Identity:	210/1002 - (20%)
Similarity:	326/1002 - (32%)	Gaps:	295/1002 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTNSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGGPER 81
            |.:|..|.....:...:|.|.|      ||...|.|            ||:||....::....|:
  Rat   548 LLDSTGTSQEYHIVKKSTRSLS------TTHVESPW------------RLIRPSVISIIGLYKEK 594

  Fly    82 GSTYGFTVRGGRE--HG-TGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRL-----DDAVHKEF 137
            |...||::.|||:  .| .|.||..:...|.|...| |:.||:||.:||..:     .:|:| .|
  Rat   595 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIH-TF 658

  Fly   138 IQLVAGQDRVTL--KVRGVGMLPVRDLPEERLSWSVVKLPSVSGTPS-------ESSFKGERRGA 193
            .|:.:|...:|:  |:....:.|.........|.|.....:..|||:       .||..|.:...
  Rat   659 KQIRSGLFVLTVRTKLLSPSLTPCSTPTHMSRSSSPSFNTNSGGTPAGGGQEEGGSSSLGRKAPG 723

  Fly   194 SRD---ISVVLHVAPRTKLGLGIC-----KGPEWKPGIFVQFTKDRSVAR-EAGLRPGDQILSVN 249
            .:|   :.|.|:..||..||:|.|     ..|   |||::......|||: |:.|..|||||.||
  Rat   724 PKDRIVMEVTLNKEPRVGLGIGACCLALENSP---PGIYIHSLAPGSVAKMESNLSRGDQILEVN 785

  Fly   250 SIDFSDVLFSEAVAVMK-------------------SSSKLDMVVRTAAGCDLFPGESSGYNSSA 295
            |::......|:..|::.                   |..::|.|:           ..|.|..|.
  Rat   786 SVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVI-----------ARSTYQESR 839

  Fly   296 SSVTGDQSPCWADAKSKRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGVEVHKQMNKTIIKLTE 360
            .:                                 :|:||.|:|..|..:.....:      |:|
  Rat   840 EA---------------------------------NSSPGLGTPLKSPSLAKKDSL------LSE 865

  Fly   361 NGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQSNPSNPSRNSTTMKRSHLRPVNSAGSGIG 425
            :..|   .|....|..|:|.....||          .:..:|.....|.:...|.||.||...
  Rat   866 SELS---QYFVHDGQGSLSDFVVAGS----------EDEDHPGSGYETSEDGSLLPVPSAHKA-- 915

  Fly   426 LSSGSAGSAGSAGSSGSGSRSGGVIAPAPAPPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQ 490
             .:.|..:.||..:||...:...|...|..|..|                              |
  Rat   916 -RANSLVTLGSQRTSGLLHKQVTVARQASLPGSP------------------------------Q 949

  Fly   491 QQQQHQQRHNRDRDRDGNGNVDRQLTGHNGNGGHRSSVG-------------------------- 529
            ..:....|..|.|..|.||..|.:  ..:|.|...|..|
  Rat   950 VLRNPLLRQRRVRCYDSNGGSDDE--DFDGEGDCISLPGVLPGPGKPLVEDDTRPALTTSSKSID 1012

  Fly   530 ---QVSHRQR------ANVAGVAATLQGSERISNLTGG-----GGAGGAGGS--NGAAGAGGDQH 578
               |....|:      .:|..:.::|.....|.|.|||     ....|:|.:  ||..|:|..:
  Rat  1013 VNKQEERLQKPLVSKACSVPLLGSSLDSEHSILNGTGGTPPKVASLPGSGETPKNGPRGSGRKE- 1076

  Fly   579 TALMDEFKRAHQRMFR-----NGFHESEHKLSSLGKSSLADRSLYGREMSLLRVK---------- 628
               |...:.:.:..:|     ......|:..|...||    .:|..|...:.|:.
  Rat  1077 ---MSGSRSSPKLEYRVPTDTQSPRSPENHTSPPQKS----ENLVSRHKPVARISPHYKRSDAEE 1134

  Fly   629 -NGGSGGGEGS-----GVMPTMRPVSMGRPLVTMSTYQERGETLKRTSIMPDESCYRNSINSNNN 687
             .||:..|..:     ...|...||: ||.....:..:.:|......|.:| .:|...|...:.|
  Rat  1135 APGGTANGPCAQDLKVQASPVKDPVT-GRQPGGTAEKELQGNPTPGDSSVP-TNCGPASTPCHPN 1197

  Fly   688 NGFSRNRSNSNTNNNNRLQSQNGVNPANG-NGSPE--LPPPPPQFANPQPKQMP----------- 738
            .|..       |.|......:...:|..| :||.|  ..|...:..:|...:.|
  Rat  1198 TGLP-------TENPQGAAPECVPHPGTGWDGSSEHLCSPGKSREVHPDSSETPTVAEQVHQPES 1255

  Fly   739 -PQHIKPMTGNAAANGSGSANGLGNGSLAKVRQP----MSPMRSASISVGGFRPPATP---QPDY 795
             .|.:.|.|....:.|           ::|::.|    :||...||......|..|.|   .|..
  Rat  1256 LSQPVSPRTSEPESQG-----------ISKMKPPSQRCVSPREKASTPPDSSRAWAAPGDSSPST 1309

  Fly   796 DAVQIRSSQGSESVSGRDVATSQQQRRTLRLGTVTIGEYGDQRTTGKRE-TLRKTNGEPASNGIL 859
            ..:.:..|.|:...:....|:...|.|:..|.       |..:..|.:| .:.|:    ..:|.|
  Rat  1310 RRIAVPMSTGAAPATAIPQASLVSQERSRGLS-------GPSKGLGTKELCIPKS----LKDGAL 1363

  Fly   860 KNGSNRSSASFNHGSSHQ----TEKTI 882
            ...:..:|...:|.||..    ||:|:
  Rat  1364 LEDTAPASGKMSHASSPSGPVATERTL 1390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	27/80 (34%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	30/103 (29%)
Pdzd2	XP_038959013.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	590..671	CDD:238492	27/81 (33%)
		PDZ_signaling	729..813	CDD:238492	27/86 (31%)
		PHA03247	<985..1446	CDD:223021	83/445 (19%)
		PDZ_signaling	2603..2677	CDD:238492
		PDZ_signaling	2731..2813	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900