DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and grip1

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_009298419.1	Gene:	grip1 / 558006	ZFINID:	ZDB-GENE-041210-125	Length:	1191	Species:	Danio rerio

Alignment Length:	1064	Identity:	208/1064 - (19%)
Similarity:	321/1064 - (30%)	Gaps:	429/1064 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ERGSTYGFTVRGGREHGTGFFVSHVEHGG-EAHLKGLRIGDQILRINGFRLDDAVHKEFIQLVAG 143
            :.|:|.|.||.||.:......||::..|| .|....|.:||.|..:||..|....|.|.|.|:..
Zfish    85 KEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLNVGDYIKSVNGINLTKFRHDEIISLLKN 149

  Fly   144 -QDRVTLKVRGVGMLPVRDLPEERLSWSVVKLPSVSGTPSESSFKGERRGASRDISVVLHVAPRT 207
             .:||.|:|.                   .:||.||...|...||        ::.|.||....|
Zfish   150 VGERVVLEVE-------------------YELPPVSVQGSGVMFK--------NVEVTLHKEGNT 187

  Fly   208 KLGLGICKGPEWKPGIFVQFTKDRSVA-----------REAGLRPGDQILSVNSIDFSDVLFSEA 261
             .|..|      :.|......|.|.|.           ||..::|||::||::.|.......:||
Zfish   188 -FGFVI------RGGAHEDRNKSRPVTITTIRPGGPADREGTIKPGDRLLSIDGIRLHGASHAEA 245

  Fly   262 VAVMKSS------------SKLDMVVRTAAGCDLFP-----GESSGYNSSASSVTGDQSPCWADA 309
            ::::|..            |.:|.|. ||:|..|..     |.|.|...|.|.....|.......
Zfish   246 MSILKQCGQEATLLIEYDVSVMDSVA-TASGPLLVEVAKSMGSSLGLALSTSMYCNKQVIIIDKV 309

  Fly   310 KSKRLTAVREESGAGGGG-------------CGLSSAP---GAGSPNWSQGVEVHKQMNKTI--- 355
            |.   .::.:..||...|             |.|:.|.   .:.|.:....:..|.|....:
Zfish   310 KP---ASIADRCGALHAGDHILSVDGTSMEYCTLAEATQLLASASEHVKMEILPHHQTRLALKGP 371

  Fly   356 --IKLT--------ENGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQSNPSNP-------- 402
              :|:.        |:||:.|:.::...       ..:|.......||..:::||||
Zfish   372 EHVKVQRSTRPLPWESGTNNNSNFLPYQ-------HYNTYHPDQSHSQAKKTSPSNPPLGSSFSP 429

  Fly   403 ---------SRNSTTMKRSHLRPVNSAG-------------SGIGLSSGSAGSAG---------- 435
                     |.|..|:.|: :.|.:..|             |.:.|:|.:.|.||
Zfish   430 TSMSAYSLSSLNMNTLPRT-MYPTSPRGTMMRRKLKKKDYKSSMSLASSTVGLAGQVVHTETTEV 493

  Fly   436 ---SAGSSGSGSR-SGGVIAPAPAPPPPAM-----NEGANASG--SVG----------------- 472
               |....|.|.: .|||.|......||.:     :..|...|  .:|
Zfish   494 TLISDSIMGFGIQLQGGVFATETLSSPPLIAYIDPDSPAERCGILQIGDRILSINGIPTEDSTLE 558

  Fly   473 --------SSLSSAITEELK----------------------------------KRKE------- 488
                    ||::|.:|.|::                                  .||.
Zfish   559 ETNQLLRDSSITSKVTLEIEFDVAESVIPSSGTFHVKLPKKPGVELGITISSPSSRKPGDALIIS 623

  Fly   489 --KQQQQQH-------------------------------QQ-------RHNRDRDRDG---NGN 510
              |:....|                               ||       :..:|.|..|   .|:
Zfish   624 DIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQQCEDLVKLKIRKDEDNSGVLRAGS 688

  Fly   511 VDRQLTGHNGNGGHRSSVGQVSHRQRANVA------------GVAATLQGSER------ISNLTG 557
            |||..         |..:..|:..|..:.|            .:..|:.|:|.      ||:||.
Zfish   689 VDRNA---------RVLLACVADEQETSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTK 744

  Fly   558 GGGAGGAGGSNGAAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREM 622
            ||.|...|..:     .||:..|:.....:.      ....|:.|.|...|:|
Zfish   745 GGLAERTGAIH-----IGDRILAINSNSLKG------KPLSEAIHLLQMAGES------------ 786

  Fly   623 SLLRVKNGGSGGGEGSGVMPTMRPVSMGRPLVTMSTYQERGETLKRTSIMPDESCYRNSINSNNN 687
            ..|::|.        .|.:|:.:|.|:...|..:|..::.|:...:.|     ..|..:|.|
Zfish   787 VTLKIKK--------QGELPSPKPPSVTGRLNNLSDLEDDGQKAGKLS-----DIYSTTIPS--- 835

  Fly   688 NGFSRNRSNSNTNNNNRLQSQNGVNPANGNGSPELPPPPPQFANPQPKQMPPQHIKPMTGNAAAN 752
                         .::.::|.:| :..:...|.:.|                      ||..|:.
Zfish   836 -------------VDSAVESWDG-SAIDATFSTQAP----------------------TGFQASG 864

  Fly   753 GSGSANGLGN-----GSLAKV---RQPMSPMRSASISVGGFRPPATPQPDYDAVQIRSSQGSESV 809
            .|..::...|     |||:.|   ||..:.:....|.|..:..|                   |.
Zfish   865 YSFHSHEWRNAKPSRGSLSPVNSSRQRNNILPDFGIGVDDWDRP-------------------SA 910

  Fly   810 SGRDVATSQQQRRTLRLGTV-----TIGEYG---------------DQRTTGKRETLRKTNGEP- 853
            ||..         ||..|.:     |:|..|               |..|.|:...||:...:|
Zfish   911 SGAS---------TLPTGLISDSRFTVGHDGTEPDQEENFWSQALEDLETCGQSGILRELEDKPD 966

  Fly   854 -----ASNGILKNGSNRSSASFNH 872
                 .:..||....:.||.|.||
Zfish   967 RLLNKRNLAILATIMSGSSLSLNH 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	26/71 (37%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	24/101 (24%)
grip1	XP_009298419.1	PDZ_signaling	79..159	CDD:238492	26/73 (36%)
		PDZ_signaling	178..261	CDD:238492	21/89 (24%)
		PDZ_signaling	276..359	CDD:238492	15/85 (18%)
		PDZ_signaling	490..578	CDD:238492	17/87 (20%)
		PDZ_signaling	591..675	CDD:238492	6/83 (7%)
		PDZ_signaling	711..792	CDD:238492	20/103 (19%)
		PDZ_signaling	1053..1133	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900