DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Grip

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster

Alignment Length:	902	Identity:	180/902 - (19%)
Similarity:	278/902 - (30%)	Gaps:	365/902 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 STTSSASSDVMTLTTTAASSWC--------AIP----------ASSRLRVLRLVRPHQRRLLVGG 78
            ||...::..||.:.....|..|        ::|          .:|:|..:.:.|
  Fly   134 STIGLSNQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVER---------- 188

  Fly    79 PERGSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVHKEFIQL-- 140
             |.| ..|.|:|||.::  ...|:||...|..:..| ::.||::||::...|......|..|:
  Fly   189 -ESG-CLGLTLRGGADY--PLIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQIIK 249

  Fly   141 ----VAGQDRVTLKVRGVGMLPVRDLPEERLSWSVVKLPSVSGTPSESSFKGERRGASRDISVVL 201
                |:|...:|::.         |:       |||:....|..|               :.:.:
  Fly   250 CGGHVSGYTNLTIEY---------DV-------SVVQSVEFSMGP---------------LLIEI 283

  Fly   202 HVAPRTKLGLGIC-------------------KGPEWKPGIFVQFTKDRSVAREAG-LRPGDQIL 246
            ......||||.:|                   :..|...|:|:......|:|...| |..|||:|
  Fly   284 ERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIASILPASIADRCGALSVGDQVL 348

  Fly   247 SVNSIDFSDVLFS--EAVAVMKSS-------------------------------SKLDMVVRTA 278
            |::........||  |.:.::.:|                               |.|:....:.
  Fly   349 SIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRGHTTLGSPKYSFSTLESRKSST 413

  Fly   279 AG------------------CDLFPGESSGYNSSASSVTGDQS-------------PCWADAKSK 312
            ||                  |.. || |:|.:.....:.|..|             |...|....
  Fly   414 AGRQRQRFARKSSLPLENPACGT-PG-STGGSMGTGGIHGSSSLGMGLGLCRAESFPVLLDCSHG 476

  Fly   313 RLTAVREE-SGAGGGGC-------------------------------------------GLSSA 333
            ....:.|. ||:||.|.                                           |.||.
  Fly   477 AGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIVAINKMYSLDAAAMRQLLEGGSSR 541

  Fly   334 PGA--GSP-NWSQGVEVHKQMNKTIIK------------------LTENGTSINNTYIASTG-GS 376
            .||  |:| ||.: :|:...|...::.                  |:.:|:|.....|:... ||
  Fly   542 NGASNGTPANWLE-LEIEFDMPDAVVPASGVFSVKLLRAGKCGLGLSVSGSSHGGLVISDVKMGS 605

  Fly   377 SVSGSGSTGSG---------------------TSGRSQQSQSNPSNPSRNSTTM--KRSHL---- 414
            ....|||..||                     ..||||    |||:.|.:.||:  ||..|
  Fly   606 PAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQ----NPSHSSSDFTTLTIKRIVLPDFL 666

  Fly   415 ---RPV--NSAGSGIGLSSGSAGSAG-----------SAGS------------------------ 439
               .|:  |...|||.|..|...|..           :||.
  Fly   667 PMSSPIYSNCPASGINLGMGMGVSTSTDHDLYSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDD 731

  Fly   440 ---------SGSGSRSGGVIAPAPAPPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQH 495
                     |||||..|...|       .:.:.|.|:...|....:.::|.||.:.:::|:|...
  Fly   732 ASLQSVQLRSGSGSNGGNQAA-------NSWSTGVNSRSYVAPPNTQSLTTELPEEEDEQEQMYP 789

  Fly   496 QQRHNRDRDRDGNG---NVDRQLTGHNGNGGHRSSVGQVSHR--------QRANVAGVAATLQGS 549
            ....||....|...   .::.::.|...:...:|| |...|:        .:..:.|:  ||.||
  Fly   790 GYELNRYASVDCTALPPPMENKVYGSAASSSSKSS-GSSLHQIIFTVRLEPKGGLLGI--TLAGS 851

  Fly   550 ERIS-NLT-GGGGAGGAGGSNGAAGAGG-----DQHTA-----------------LMD-EFKRAH 589
            |.|: ::| .|...||....||....|.     |:|:.                 |:| :..|:|
  Fly   852 EDITKSITISGLVEGGIAHKNGQIHVGDQLLAIDEHSVQGMPLSHATSLLQNLGDLVDLKILRSH 916

  Fly   590 QRMFRNGFHESE-----HKLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVM 641
            .  ..||.|..:     .|:....:|..|:     .|.|    |..|||...|.|.:
  Fly   917 D--LANGSHLPQTQAIYAKVQRRPRSPSAN-----TEAS----KESGSGNANGGGAV 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	21/76 (28%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	23/131 (18%)
Grip	NP_572285.2	PDZ	82..147	CDD:294084	4/12 (33%)
		PDZ_signaling	183..254	CDD:238492	20/84 (24%)
		PDZ_signaling	278..375	CDD:238492	22/111 (20%)
		PDZ	496..>521	CDD:294084	0/24 (0%)
		PDZ_signaling	571..658	CDD:238492	21/90 (23%)
		PDZ_signaling	832..913	CDD:238492	18/82 (22%)
		PDZ_signaling	973..1055	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900