DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and pard3b

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_002936439.2	Gene:	pard3b / 496480	XenbaseID:	XB-GENE-5816818	Length:	1137	Species:	Xenopus tropicalis

Alignment Length:	1050	Identity:	197/1050 - (18%)
Similarity:	331/1050 - (31%)	Gaps:	321/1050 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MTAASASISTSASLTNSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRL------- 61
            :|:::..|.|...:..|:......::....:||.|:| ..:...:......:|...:.
Frog   126 VTSSALKIGTPLLVRRSSDPTVGPAVDFHPSSSQSAD-QNVNDASQGLSRVLPPDEQTDQNTGLQ 189

  Fly    62 RVLRLVRPHQRRLLVGGPERGSTYG------FTVRGGREHGTGFFVSHVEHGGEAHLKGL-RIGD 119
            :.|..:|...|::.:.|  .|...|      ::...||  ..|.::..:|....:..:|| :..:
Frog   190 KPLYKIREITRKVEISG--SGGPLGIHVVPFYSSFSGR--ALGLYIRGIEESSRSKREGLFQENE 250

  Fly   120 QILRINGFRLDDAVHKEFIQLVAGQD--RVTLKVRGVGMLPVRDLPEER-------------LSW 169
            .|::||...|.|   :.|.|   .||  |..:|.:.|.:..|  |||:|             |..
Frog   251 CIVKINNVELID---RSFAQ---AQDIFRQAMKQQNVLVETV--LPEKRELYEKSVISSLFVLDD 307

  Fly   170 SVVKLPSVSGTP------------------------------------SESSFK---------GE 189
            .:.::|.:...|                                    |||.|.         |.
Frog   308 DIDEVPDIKPPPPPVHVNRSIKMPEQVNGIDPTGTKIQQPPLSPNLISSESKFSSPSLSPLGFGN 372

  Fly   190 RRGASRDISVVLHVAPRTKLGLGICKGPEWKPGI-FVQFTKDRSV-----------------ARE 236
            ::...             ||.:.:.||.|   |: |...|:|.:|                 .::
Frog   373 KKNGK-------------KLRIDLTKGAE---GLGFTVVTRDSTVHGPGPIFVKNILPKGAAVKD 421

  Fly   237 AGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCD--LFPGESSGYNSSASSVT 299
            ..|..||:||.||..|.:.....|.||:::|:...:.|....|..|  ..|.|..|..
Frog   422 GRLLSGDRILEVNGKDIAGKTQEELVAMLRSTKLGESVSLVVARQDETFLPRELKGET------- 479

  Fly   300 GDQSPCWADAKSKRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGVEVHKQMNKTII----KLTE 360
              ::..:....:.::|.....:.:|..|.|:|.   .|:.:...|.::...: |:||    ...:
Frog   480 --ENLVFPPDNTAQMTFEIPLNDSGSAGLGISL---KGNKSRETGADLGIFI-KSIIHGGAAFKD 538

  Fly   361 NGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQSNPSNPSR-------NSTTMKRSHLRPVN 418
            ....:|:..:|..|.|.:..|......|..||...:.|.....:       :..|.:||.....|
Frog   539 GRLRVNDQLVAVNGESLLGKSNRDAMETLRRSMSMEGNIRGMIQLVILRRLDWQTEERSETFQKN 603

  Fly   419 SAGSGIGLSSGSAGSAGSAGSSGSGSRSGGVIAPAPAPPPPAMNEGANASGSVGSSLSSAITEEL 483
            :. ..:.:|..:........||....|:.....|.|.||.|.               ...|.|..
Frog   604 TI-ENLAVSEQNGVQEKLKDSSRFNDRNSENYIPPPIPPHPK---------------EHIIVESP 652

  Fly   484 KKRKEKQQQQQHQQRHNRDR------DRDGNGNVDRQLTGHNGNG-GHRSSVGQVSHRQRANVAG 541
            |.|...:.|..........|      |....|::....:|..|.. |.|..:.:.|..:....|
Frog   653 KLRNVAESQPNDSLNIKASRSMDIVADESNIGSLREHQSGSPGKDFGPRLGLKKSSSLESLQTA- 716

  Fly   542 VAATLQGSE------RISNLTGGGGAGGAGGSNGAA------GAGGDQHTALMDEFKRAHQRMFR 594
             .|.::.:|      |...:.|    .|...|..||      |..|::..||.|  ..:|
Frog   717 -FAEVKKNELPFYRPRPHMVRG----RGCNESFRAAIDKSYDGPEGEEEDALSD--LSSH----- 769

  Fly   595 NGFHESEHKLSSLGKSSLADRSLYGREMSLLRVK--NGGSGGGE-----------------GSGV 640
            :|......:|:.||...:.|.....:|.....||  ...:.|.|                 |.||
Frog   770 SGRESPNSELTPLGNQEMEDTDKSKKEKKKKDVKKEKAKAKGKEKKKKDDAEEHEKKAKKKGFGV 834

  Fly   641 MPTMRPVSMGRPLVTMSTYQERGETLKRTSIMPDESCYRNSINSNNNNGFSRNRSNSNTNNNNRL 705
                    :||   .:...:|:|.. |:.::..:|    |.:.....   .|.|.|.   .:..|
Frog   835 --------LGR---LIKKKEEKGNQ-KQGTLKEEE----NEVEKMKE---ERERINI---KHQEL 877

  Fly   706 QSQNGVNPANGNGSPELPPPPPQFANPQPKQMPPQHIK-------PMTGNAAANGSGSANGLGNG 763
            :.|...|....|.|.::          :...|.|.:.|       |:..||
Frog   878 REQQAKNLLGYNWSHDM----------EDDDMDPNYAKVNHFQEAPLNHNA-------------- 918

  Fly   764 SLAKVRQPMSPMRSASISVGGFRPPATPQPDYD-AVQIRSSQGSE--------------SVSGRD 813
                 .:|.|             ||.|..|.|. ..|:.||:..:              |.|||.
Frog   919 -----HRPYS-------------PPTTLPPSYPRETQVLSSEREDLYAKINKKQQAPDKSDSGRS 965

  Fly   814 VATSQQQRRTLRLGTVTIGEYGDQRTTG------KRETLRKTNGE--------PASNGILKNGSN 864
            .:.:..:.:.||:      ||...:..|      ..|..|....|        |.::.:..:|..
Frog   966 TSGTADRIQQLRM------EYHQAKQEGFLMHEDDDELGRHLEYEQTWIPIRSPEASRLRYDGME 1024

  Fly   865 RSSASF-NHG 873
            |..||. .||
Frog  1025 RQYASLPRHG 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	19/78 (24%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	23/96 (24%)
pard3b	XP_002936439.2	DUF3534	2..83	CDD:338230
		PDZ_signaling	199..284	CDD:238492	22/94 (23%)
		PDZ	381..467	CDD:214570	22/88 (25%)
		PDZ_signaling	498..586	CDD:238492	18/91 (20%)
		DUF3824	<1014..1128	CDD:372351	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910