DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5921 and Patj

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_477342.1	Gene:	Patj / 44100	FlyBaseID:	FBgn0067864	Length:	871	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	159/816 - (19%)
Similarity:	244/816 - (29%)	Gaps:	274/816 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 GSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVHKEFIQLVAGQD 145
            |:..||.:.|.|  .:|..|..:..||.|...| ||.||.||:|....|.:.| .|.:..|..|.
  Fly   156 GTGLGFGIIGAR--NSGVIVKTILPGGVADKDGRLRSGDHILQIGDVNLHEMV-SEQVAAVLRQS 217

  Fly   146 --RVTLKVR----------------GVGMLPVRDL--PEERLSWSV-VKLPSVSGTPSESS---- 185
              .|.|.|.                |..::|.|.|  |.|...:.: ...|.:.|..|.:|
  Fly   218 GTHVRLVVARPVEQSVPTPQYALEPGTAVVPTRVLVDPAELERYLISTGYPEIFGESSTASTPQT 282

  Fly   186 --------FKGERR---GASRDISVVLHVAPRTKL---------GLGI------CKGPEWKPGIF 224
                    ::||..   ..:.|:..:|.:....||         ||||      |:..|.. |||
  Fly   283 TTEDDRFVYRGETSMLIDPNIDLEELLALPETEKLQVELKKDANGLGITIAGYVCEKEELS-GIF 346

  Fly   225 VQFTKDRSVAREAG-LRPGDQILSVNSIDFSDVLFSEAVAVMKSSS--------------KLDMV 274
            |:.....|.|..:| :|..|:|:.|:..........:||.::|.|.              |.:.:
  Fly   347 VKSVSPGSAADLSGRIRVNDRIIEVDGQSLQGYSNHQAVELLKKSGQVVNLRLERYLRGPKFEQL 411

  Fly   275 VRTAAGCDLFPGESSGYNSSA---------SSVTGDQSPCWADAKSKRLTAVREESGAGGGGCGL 330
            .:..|..|..|..:.|..|.|         ||.|        ...|:.:|...||.........:
  Fly   412 QQAIAANDKLPSSAPGTPSRAPMPTPVATTSSAT--------TTPSRSITRELEEEALPAPEAFM 468

  Fly   331 SSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGTSINNTYIASTGG--------SSVSGS------ 381
            ::.|..                          |::..|.::|.|.        .|:.||
  Fly   469 TTPPSV--------------------------TTMTTTTLSSFGAGKQLVAVRDSLDGSTKIIPT 507

  Fly   382 ------GSTGSGTSG--RSQQSQSNPSNPSRNSTTMKRSHLRPVNS------------AGSGIGL 426
                  ..|.:..||  ...:..::|.......|.:.|...:.|.|            |..|:|:
  Fly   508 EVVPLADKTEAKNSGVITRHKYYTDPELSDDAETEIIRKWQKIVGSDVEVIVAQIKKFAVGGLGI 572

  Fly   427 S-SGSAGSAGSAGSSGSGSRSGGVIAP-----APAPPPPAMNEGANASGSV-----GSSLSS--- 477
            | .|:....|           |..:.|     :..|..|....|...||..     |..|..
  Fly   573 SLEGTVDVEG-----------GREVRPHHYIRSILPDGPVGVNGVLRSGDELLEVNGERLLGMNH 626

  Fly   478 ----AITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNVD-RQLTGHNGNGGHRSSVGQVSHRQRA 537
                ||.:||.                          :| |.:.|.|.|............:...
  Fly   627 LEVVAILKELP--------------------------LDVRMVCGRNRNSSLLPFSDDTLKKLSN 665

  Fly   538 NVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAGGDQHTALMDEFKRAHQRMFRNGFHESEH 602
            |...:   |..::|:......|....||     :.|.||...|....|.
  Fly   666 NFENL---LPATDRLVKAKSDGSLATAG-----SVADGDSVAAAAASFS---------------- 706

  Fly   603 KLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVMPTMRPVSMGRPLVTMSTYQERGETLK 667
            ||.|.....|...:::..:..::.:..|..  |.|..::....|:.....|:.:.:....|....
  Fly   707 KLKSRSLEPLTGLAMWSSQPQIIELVKGDR--GLGFSILDYQDPLDPNDTLIVIRSLVPGGVAQL 769

  Fly   668 RTSIMP-DESCYRNSINSNNNN---------GFSRN-------------------RSNSNTNNNN 703
            ...::| |...:.||||..|.:         |.|:.                   .||::|.:..
  Fly   770 DGRLIPGDRLLFVNSINLENASLDQAVQALKGASKGVVRIGVAKPLPMTDNSLKACSNASTTSEE 834

  Fly   704 RLQSQNGVNPANGNGSPELPPPPPQFANPQPKQMPP 739
            .|.:|               |.||......|..|||
  Fly   835 TLDAQ---------------PSPPALPTVAPPAMPP 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	25/72 (35%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	25/108 (23%)
Patj	NP_477342.1	L27	12..70	CDD:295425
		PDZ_signaling	154..226	CDD:238492	25/72 (35%)
		PDZ_signaling	318..400	CDD:238492	21/82 (26%)
		PDZ_signaling	557..643	CDD:238492	21/122 (17%)
		PDZ_signaling	726..807	CDD:238492	15/82 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900