DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and CG34375

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001163693.1	Gene:	CG34375 / 42715	FlyBaseID:	FBgn0085404	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	565	Identity:	111/565 - (19%)
Similarity:	163/565 - (28%)	Gaps:	186/565 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 LGLGICKGPEWKPGIFVQFTKDRSVAREAGLRPGDQILSVNSIDFSDVLFSEAVAVMKS--SSKL 271
            |||.:.:.| |.|..:|...:.:|.|...|:|.||.:|.:|..|...:..||....::.  .|..
  Fly    15 LGLNLSRAP-WDPYPWVSGVQAKSSAERGGVRLGDTLLELNGADVLGLKISELANRLQDHWQSGA 78

  Fly   272 DMVV----RTAAGCDLFPGESSGYNSSASSVTGDQS---------------------------PC 305
            ::|.    |..|..|  |.|.....|.|.....:|.                           |.
  Fly    79 EVVTLMMWRQQANID--PNEDPAEASHAVQHGINQQSLQKFATCLQHISQLLECPVCLEVIKPPG 141

  Fly   306 W-----------ADAKSKRLTAVREESGAGGGGCGLS---------SAP-GAGSPNWSQGVEVHK 349
            |           ..::|.:....|...|. .|.|.||         |.| ..|..|.....:.|.
  Fly   142 WQCCNGHVLCNNCRSRSVKCPVCRVPLGP-RGRCLLSDKLFTLLAESFPCDGGKTNKVAASQGHG 205

  Fly   350 QMNKTIIKLTENGTSINNTYIASTGGSSVSGSGSTGSGTS----------------GRSQQSQSN 398
            ::: ::.|.|....:.....:|.|.    ||....|...|                .:|||.|..
  Fly   206 KLS-SVNKCTNEYHNQPKMALAKTS----SGKSKCGKQISRQLETVLVDQSPREIRRKSQQGQEQ 265

  Fly   399 PSNPSR----NSTTMKRSHLRPVNSAGSGIGLSSG--------SAGSAGSAGSSGSGSRSGGVIA 451
            ......    ..|.:|..|........|..|.::.        |..|....|....|.|...|
  Fly   266 EQAVQEAVLPRCTLIKVQHQEAAVEHFSEEGHNNMLVKPKLKLSKKSWRITGPDQDGLRCDEV-- 328

  Fly   452 PAPAPPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNVDRQLT 516
                   ..:|.|.                      :.|:|||.|:|.....::..:...:.| .
  Fly   329 -------ATINNGV----------------------QVQEQQQQQERQQLGHEKSASSESEYQ-N 363

  Fly   517 GHNGNG----GHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAGGDQ 577
            .|...|    .|...:||....:.:.||     :|....:.|  .||.:..||....|..||.:|
  Fly   364 YHCPTGKSCSSHSYQLGQPVANKLSTVA-----MQALAVVEN--SGGASLSAGSHKQAPAAGVNQ 421

  Fly   578 HTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVMP 642
            ...|                     :..|:|:          ||..|||..:|
  Fly   422 ELPL---------------------EAGSIGR----------REWQLLRHLSG------------ 443

  Fly   643 TMRPVSMGRPLVTMSTYQERGETLKRTSIMPDE--SCYRNSINSN 685
                   ...|..:..|...||.|.....:|.|  :|.|.|..|:
  Fly   444 -------DHRLAVLQIYGTFGERLHVRPQLPLEGVACLRLSEESS 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	20/72 (28%)
CG34375	NP_001163693.1	PDZ	13..86	CDD:238080	20/71 (28%)
CG34375	NP_001163693.1	RING	129..168	CDD:238093	4/38 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900