DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and bbg

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001246755.1	Gene:	bbg / 39583	FlyBaseID:	FBgn0087007	Length:	2637	Species:	Drosophila melanogaster

Alignment Length:	1040	Identity:	202/1040 - (19%)
Similarity:	326/1040 - (31%)	Gaps:	393/1040 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TAASASISTSASLTNSAST---DCSSSMQGSTTSSASS-----DVMTL----------------- 44
            ||..:|..|...|..|:..   .||||...|..:.|.|     ||...
  Fly  1775 TAPISSSFTRKPLNRSSENLLDSCSSSSAPSLKTRAMSVENLNDVQRQYQLAKQLPQLHVADSMY 1839

  Fly    45 ---TTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGGPERGSTYGFTVRGGREHGTGFFVSHVEH 106
               |.|...|:.::|.                                   |.|| |.:.|.||.
  Fly  1840 SLNTATPTPSYASLPR-----------------------------------RSHG-GSYSSGVER 1868

  Fly   107 GGEAHLKGLRIGDQILRINGFRLDDAVHKEFIQLVAGQDRVTL-KVRGVG-------MLPVRDLP 163
                     ||.     .:|...|.|..|..|..:..|.|.:| |:||:.       :.|:.|||
  Fly  1869 ---------RIS-----FSGEGGDAANRKAAITNILEQRRRSLSKLRGLVIPERPQLLEPILDLP 1919

  Fly   164 EERLSWSVVKLPSVSGTPSESSFKGERR-------------GASRDISVVLHVAPRTKLGLGICK 215
            |.:   |.||  :.||..|..|..||..             ||:.:...:|:...|..|...:.:
  Fly  1920 EIK---SQVK--AASGEDSTDSGLGESHRSTVNRNCQLGAGGAANNYRSILNTNQRRPLEQQLSQ 1979

  Fly   216 GPEWKPGIFVQFTKDRSVAREAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVRTAAG 280
            .|...|...:...:.||:.......|.||....:|:      ||....|.....|. .:.||.
  Fly  1980 PPAKPPRTSLTPLQPRSMMIPPPPPPLDQESDTDSV------FSHTARVATPPEKF-ALTRTL-- 2035

  Fly   281 CDLFPGESSGYNSSASSVTGDQSPCWADAKSKRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGV 345
                   ||..|:|.:|           :.:..||     ||:..|.....|:.|:     :..|
  Fly  2036 -------SSETNTSIAS-----------SNTSTLT-----SGSSAGSQASCSSLGS-----TPAV 2072

  Fly   346 EVHKQMNKTIIKLTENGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQSNPSNPSRNSTTMK 410
            ::.:::.|:.:        ||...:|.:...|:..|....|..| |.|:..::.::....|...:
  Fly  2073 DLTRRVLKSQV--------INGEAVALSSRKSILASAKCRSAKS-RGQEEDNDSTDGEACSLANR 2128

  Fly   411 RSHLRPVNS---------------------AGSGIGLSSGSAGSA-----------------GSA 437
            |  ::|::|                     ..:.:.|:|.:..|:                 ..|
  Fly  2129 R--MKPISSYKLQQQQIQLGKQLVVDKLINVAAYVELTSDTDDSSRRSDTPAKISAMFIDEERKA 2191

  Fly   438 GSSGSGSRSGGV----IAPAPAPP--PPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQ 496
            ...|..::...|    :.|...|.  |.|..|          .|....|.||:::.|:....|.|
  Fly  2192 SFKGDPNQQAKVKVEQVKPMVLPMLLPSAKRE----------PLKQQTTAELREKFERSAAAQAQ 2246

  Fly   497 -QRHNRDRDRDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQR--------ANVAGVAATLQGSERI 552
             |.|:         .|..::|             |..|.:|        ::.:||::|.|.....
  Fly  2247 TQNHS---------PVIHKVT-------------QKPHHERFSSLDSLASSSSGVSSTTQNVSTT 2289

  Fly   553 SNLTGGGGAGGAGGSNGAAGAGGDQHTALMDE----------FKRAHQRMFRNGFHESEHKLSSL 607
            .......|:..:.|||.:.....|.. .:::|          |....||         |:..||:
  Fly  2290 QETATEFGSFSSLGSNQSLITAQDVQ-QIVEEADPPLKTPEAFIIVLQR---------ENPESSI 2344

  Fly   608 GKSSLADRSLY-GREMSLLRV--------------------KNGGSGGG----EGSGVMPTMRPV 647
            | .:||..|.| .:|:::.::                    .||.|..|    |...|:.|.||
  Fly  2345 G-ITLAGGSDYEAKEITIHKILSNTPAAKDGRLKKGDRILAVNGMSMRGLTHRESISVLKTPRP- 2407

  Fly   648 SMGRPLVTMSTYQE----RGETLKRTSIMPDESCYRNSINSNNNN----GFSRNRSNSNTN---- 700
                .:|.:.|..|    :..|.||:|:        .|::|.|..    .:.|.|:....:
  Fly  2408 ----EVVLVVTRSESLVVKALTKKRSSL--------GSLSSLNEKPTELDYERKRNYHKASRSLD 2460

  Fly   701 ------NNNRLQSQNGVNPANGNGSPELPPPPPQFANPQPKQMPPQ------------------- 740
                  :|...:|.....|:.|:.||           |||..:..:
  Fly  2461 LDLDLVSNEAGESPVATTPSTGSVSP-----------PQPASLHDEDAEATIAGIRARRQLSRGD 2514

  Fly   741 ----------------------HIKPMTGNAAANGSGS--------ANGLGNGSLAKVRQPMS-- 773
                                  .|:....:|||:|.|:        :.|||.........|:.
  Fly  2515 AAKLSTSELLERAAEARNAIAAEIRAQAEDAAASGGGARCVEIVKDSCGLGFSIEGGFDSPLGNR 2579

  Fly   774 PMRSASISVGGFRPPATPQPDYDAVQIRSSQGSESVSGRDVATSQQQR-------RTLRLGTVTI 831
            |:....:.:||......        |:|:  |.|.:|....:||:..|       :.|.||.|.|
  Fly  2580 PLIVKKVFMGGAAQKTN--------QVRN--GDEILSINGASTSRMTRVDAWNYMKQLPLGPVKI 2634

Fly 832 831
Fly 2635 2634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	18/70 (26%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	15/78 (19%)
bbg	NP_001246755.1	PDZ_signaling	90..177	CDD:238492
		ATP-synt_B	<1084..>1109	CDD:304375
		PDZ_signaling	2331..2413	CDD:238492	22/96 (23%)
		PDZ_signaling	2553..2634	CDD:238492	19/90 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900