DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and GRID2IP

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001138590.1	Gene:	GRID2IP / 392862	HGNCID:	18464	Length:	1211	Species:	Homo sapiens

Alignment Length:	845	Identity:	157/845 - (18%)
Similarity:	248/845 - (29%)	Gaps:	327/845 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PHQRRLLVG---GP----------ERGSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKGLRIGDQ 120
            |.:..||||   ||          :...::|||:||   ||. .::..|..|..|....|:.||:
Human   260 PRRASLLVGGLAGPGGARRTVRVYKGNKSFGFTLRG---HGP-VWIESVLPGSPADNAALKSGDR 320

  Fly   121 ILRINGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVR------DLPE-----ERLSWSVVKL 174
            ||.:||..:.:..|.:.:.::.|...:...|...|::|..      |.|.     ..|.|....|
Human   321 ILFLNGLDMRNCSHDKVVSMLQGSGAMPTLVVEEGLVPFASDSDSLDSPNPSSALTSLQWVAEIL 385

  Fly   175 PSVSGTPSESSFKGERRGASRDISVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAREAGL 239
            |        ||.:.:.|..|:.:..:|....|    .|:|:..|       .|.:.|::
Human   386 P--------SSIRVQGRTFSQQLEHLLTPPER----YGVCRALE-------SFFQHRNI------ 425

  Fly   240 RPGDQILSVNSIDFSDVLFSEAVAVM------------------KSSSKLDMVVRTAAGCDLFPG 286
               |.::    :|...||.:.|..|:                  |.:..|.....||.     |.
Human   426 ---DTLI----VDVYPVLDTPAKQVLWQFIYQLLTYEEQELCQEKIACFLGYTAMTAE-----PE 478

  Fly   287 ESSGYNSSASSVTGDQSPCWADAKSKRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGVEVHKQM 351
            ......|..:.....:|...|.:..:|  ::|.:....|..||.|..|               :|
Human   479 PELDLESEPTPEPQPRSSLRASSMCRR--SLRSQGLEAGLSCGPSECP---------------EM 526

  Fly   352 NKTII---KLTENGTSI----NNTYIASTGGSSVSGSGSTGSGTSGRSQQSQSNPSNPSRNSTTM 409
            ...:|   :...:|||:    |...:::......|...|:..|..|...:|:::|..||...||.
Human   527 PLPLIPGERQAGDGTSLPETPNPKMMSAVYAELESRLNSSFKGKMGTVSKSRASPPGPSPAVTTG 591

  Fly   410 KRSHLRPVNSAGSGIG--------------LSSGSAGSAGSAGS----SGSGSRSGGVIAPAPAP 456
            .|:.        ||:.              |.||...|..|:.|    |...||     ||:|.|
Human   592 PRTL--------SGVSWPSERLLPSPCYHPLCSGGLASPSSSESHPYASLDSSR-----APSPQP 643

  Fly   457 PPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNVDRQLTGHNGN 521
            .|          |.:......:........:.|.....|..| :||.||
Human   644 GP----------GPICPDSPPSPDPTRPPSRRKLFTFSHPVR-SRDTDR---------------- 681

  Fly   522 GGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAGGDQHTALMDEFK 586
                                      ..:.:|...|                   ....::|:|.
Human   682 --------------------------FLDVLSEQLG-------------------PRVTIVDDFL 701

  Fly   587 RAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVMPTMRPVSMGR 651
            ..........||:.:....:..:||.:|
Human   702 TPENDYEEMSFHDDQGSFVTNERSSASD------------------------------------- 729

  Fly   652 PLVTMSTYQERGETLKRTSIMPDESCYRNSINSNNNNGFSRNRSNSNTNNNNRLQSQNGVNPANG 716
             .::.|   |.|.:|..:||
Human   730 -CISSS---EEGSSLTYSSI--------------------------------------------- 745

  Fly   717 NGSPELPPPPPQFANPQPKQMPPQHIKPMTGNAAANGS-GSANGLGNGSLAKVRQPMSPMRSASI 780
              |..:||||  .:.|.|..:|....||  .:.:::|| |.|..|.. .|.::..|:.|
Human   746 --SDHIPPPP--LSPPPPPPLPFHDAKP--SSRSSDGSRGPAQALAK-PLTQLSHPVPP------ 797

  Fly   781 SVGGFRPPATPQPDYDAVQIRSSQGSESVSGRDVATSQQQRRTLRL-------GTV--TIGEYGD 836
                  ||..|.|  ..|.......|..:..|...||....:.||.       ||:  .:||..|
Human   798 ------PPPPPLP--PPVPCAPPMLSRGLGHRRSETSHMSVKRLRWEQVENSEGTIWGQLGEDSD 854

Fly 837 836
Human 855 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	19/69 (28%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	15/96 (16%)
GRID2IP	NP_001138590.1	PDZ_signaling	14..74	CDD:238492
		HN_L-delphilin-R1_like	133..212	CDD:259820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..269		4/8 (50%)
		PDZ_signaling	278..353	CDD:238492	20/78 (26%)
		HN_L-delphilin-R2_like	389..468	CDD:259821	16/102 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..502		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..549		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..600		11/39 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..672		13/68 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..783		23/156 (15%)
		FH2	820..1188	CDD:280362	10/35 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810