DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and ssp6

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001286952.1	Gene:	ssp6 / 38694	FlyBaseID:	FBgn0035676	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	1084	Identity:	190/1084 - (17%)
Similarity:	306/1084 - (28%)	Gaps:	474/1084 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TAASASISTSASLTNSASTDCS-------------------------------SSMQGSTTSSAS 38
            ||||::.:|:|:::.|||...|                               |..|.|...:.:
  Fly    15 TAASSAATTAAAVSISASNATSVGSLIAAACQQEQPHPHQHYSQSQQQHLYHQSHQQASHYVNGT 79

  Fly    39 SDVMTL-------TTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGGPE------------RGST 84
            ..:..|       .:.....:..:..|:.:    |.|....|.|...|:            :.::
  Fly    80 GSLGRLKFHKSLDASDEEIEYAQLSRSTHI----LGRHKSERYLASNPDEDRRRRTIIVEKKNNS 140

  Fly    85 YGFTVRGGREHGTGF----------FVSHVEHGGEAHLKGLRIGDQILRINGFRLDDAVHKEFIQ 139
            ||||:   :.:|..:          :|.:||:||.|:..|:|.||.||.|||..::.|.||..::
  Fly   141 YGFTL---QSYGIHYKRDEELEMITYVDYVEYGGPAYRAGMREGDVILSINGKDMEKADHKTIVE 202

  Fly   140 LVAGQD--------------RVTLKVRGVGM---------------LPVRDLPEERLSWSVVKLP 175
            .:...|              :|.|.:|.:.:               |..|:|.|.:  |....||
  Fly   203 FIKQCDTRMRMVVLFEDCVRKVDLHMRYIQLQSMLQQKMNELERVHLRERELLEGK--WKTHSLP 265

  Fly   176 SVSGTPSESSFKGERRGASRDISVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAREAGL- 239
            :             |:.|:.:.|                  |....|:     ....||.|||.
  Fly   266 A-------------RKKANANTS------------------PSDGEGV-----SPTEVAGEAGFY 294

  Fly   240 RPGDQILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPGESSGYNSSASSVTGDQSP 304
            ||     ::::.|..::
  Fly   295 RP-----ALSTEDVPNI------------------------------------------------ 306

  Fly   305 CWADAKSKRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGTSINNTY 369
                       |.|:.   |.||.|:...|..                   ..||.:  .::.||
  Fly   307 -----------AARQH---GVGGPGIIPPPAQ-------------------FMLTYH--YLDPTY 336

  Fly   370 ---IASTGGSS---VSGSGSTGSGTSGRS-------QQSQSNPSNPSRNSTTMKRSHLRPVNSAG 421
               :..|.|||   |.|.|...|.:..:.       ||::|..:|.....||...:...
  Fly   337 RYVLRPTHGSSEEFVDGLGLQRSSSDHQPPAQRYVLQQTESVDANSMTQPTTTAPTQYH------ 395

  Fly   422 SGIGLSSGSAGSAGSAGSSGSGSRSGGVIAPAPAPPP-----------PAMNEGANASGS---VG 472
                                  |.:||.:.| |||||           |...|...:||.   ||
  Fly   396 ----------------------STTGGSVKP-PAPPPRTCEKHKPPAKPPKPEKEKSSGKHCHVG 437

  Fly   473 SSLS-------------SAI-------------------TEELKKRKEKQQQQQHQQRH-NRDRD 504
            .|.:             ||:                   |..:..|:..:|.::|..:| :|||:
  Fly   438 HSCNPCLGHFRWKSAEKSAVPAPDNVSLDAYDLASPCCDTHCVPSRRRHRQHKEHTHKHKHRDRE 502

  Fly   505 RDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNG 569
            |                      |.....|.|......|:.                    .:||
  Fly   503 R----------------------VESKEQRVRPKSTSHASP--------------------NANG 525

  Fly   570 AAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGG 634
            .||:|...|          |.....:  ||.:.:.....:.....:....::..:..|.:...
  Fly   526 GAGSGHHHH----------HHHHHHS--HEQQQQQQQQQQQQQQQQQQQQQQQPIQTVPHHHH-- 576

  Fly   635 GEGSGVMPTMRPVSMGRPLVTMSTYQERGETLKRTSIMPDESCYRNSINSNNNNGFSRNRSNSNT 699
                      .|..|..|....|   :.|.|..|...:........|::|..::.|:...:.|.|
  Fly   577 ----------YPHQMHNPCQVQS---QSGSTRSRYFDLASGLASHCSLHSCTSSEFATGDTASYT 628

  Fly   700 N--NNNRL----QSQNGVNPANGNGSPELPPPPPQFANP-------------------------- 732
            .  :.:.|    .|:...:..:...|.:.....||...|
  Fly   629 TSISTDTLFWDPTSETAQSRQHSTKSRQSYEQQPQQQQPTHQGHHHHHHHQGDYHQRYHVTTTQM 693

  Fly   733 QPKQMPPQHI----KPMTGNAAANGSGSANGLG-----------NGSLAKVRQPMSPMR------ 776
            ||:|:.|..|    ||.:.:..||.:|...|.|           ...:|:.|..| |.|
  Fly   694 QPQQIYPNTIAYVQKPKSWDNLANKAGFNVGYGYLDTVAVKPAIKMQIAQQRHSM-PRRNPYGRY 757

  Fly   777 SASISVGGFRPPAT----PQPDYDAVQIRSSQGSESVSGRDVATSQQQ----------------- 820
            |....|..:.||.|    .........|.:....|.::..|..|.|||
  Fly   758 STYGDVENYAPPPTEFVGELTTTTTTTITAKSTEELLAACDCLTPQQQAAIKAAQYQLSQNQKLS 822

  Fly   821 --------------RRTLRLGTVTIGEY----GDQRTTGKRETL 846
                          |.|..:||.|..:.    ||.:||.:...|
  Fly   823 HQNSCQLGYYSHLPRPTTDVGTSTTSQQVHGAGDVQTTSEATRL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	26/93 (28%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	11/79 (14%)
ssp6	NP_001286952.1	PDZ_signaling	130..216	CDD:238492	24/88 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900