DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Dlg5

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_609505.1	Gene:	Dlg5 / 34573	FlyBaseID:	FBgn0032363	Length:	1916	Species:	Drosophila melanogaster

Alignment Length:	1002	Identity:	207/1002 - (20%)
Similarity:	321/1002 - (32%)	Gaps:	265/1002 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGGPERGS 83
            :|..|.| ..|:.....:.|..:|.:..:.........|..::.:|:.....|.|..:.....||
  Fly   362 DSVKTLC-DKMRHERDKAISDSLMAIRDSEKIKKQKDEAQKKIDLLKEQMEQQERQNLDSNASGS 425

  Fly    84 TYGFTVRGGREHGTGFFVSHVEHGGEAHLKGLRIGDQILRINGFRLDDAVHKEFIQLVAGQDRVT 148
            ...|  |.....|....  .||..|..|...|          |..|||:..:   :||.|   ||
  Fly   426 RRSF--RPSSYEGEDLL--EVELSGYEHTSDL----------GIILDDSNKR---KLVCG---VT 470

  Fly   149 LKVRGVGMLPVRD-------LPEERLSWSVVKLPSVSGTPSESSFKGERRGASRD-ISVVLHVAP 205
            ......|.|.:.|       |..:.||..:|.....:..|.........|.:.|. .||.|....
  Fly   471 SSSPACGKLKINDVICKVNNLDCQSLSKRMVLDEIRACAPRSLLLVSRTRHSKRHAYSVQLKTRD 535

  Fly   206 RTKLGLGIC-KGPEWKPGIFVQFTKDRSVA-REAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSS 268
            |.      | .|.:...|:|:...:..|:| .|..|..||::||:|:.....|...|.|..:.:.
  Fly   536 RD------CPHGLQLDMGVFIAKIEQNSLAFYEPELDVGDRVLSINNKSMDSVQSIEEVMQLMND 594

  Fly   269 SKLDMVVRTAAGCDLFPGESSGYNSSASSVTGDQSP---CWADAKSKRLTAVREESGAGGGGCGL 330
            .:                 |.|.|..|.....||.|   ..:.|::..:.:::..|.|||||
  Fly   595 PR-----------------SDGLNLFALKYVQDQLPPGMTTSSAQTDSIDSMQHVSSAGGGG--- 639

  Fly   331 SSAPGAGSPNWSQGVEVHKQMNKTIIKLTENGTSINN------------TYIASTGGSSVS---- 379
            .|.|.:.:.:.|:..|...:.    :|.::.||..:|            ..:.|...|..|
  Fly   640 GSGPSSATKHPSRFAEFFFRK----LKFSKPGTPEDNFEQEHDDAIAALDSVLSENSSEKSKENL 700

  Fly   380 ----------GSGSTGSGTSGRSQQSQSNPSNPSRNSTTMKRSHLRPVNSAG-----------SG 423
                      ...|...||..|:..|..||:...|.:.  |:..|..:.:||           ..
  Fly   701 FNRKKRTKKEKEASKSMGTWPRTNISHENPTGTMRGNE--KKRALMSLFTAGPINVDKDDELMGE 763

  Fly   424 IG---------------------LSSGSAGSAGSAGSS-------GSGSRSGGVIAPAPAPPPPA 460
            :|                     :|...|...||.|.:       .|...|.||.|..|..||..
  Fly   764 VGVPEKQPAALIQDQLPPPLPPQMSKPLAHIRGSNGGAIKTHPNRNSNPVSSGVSALFPPGPPNG 828

  Fly   461 MNEGANASGSV--GSSLSSAITEELKKR--------------KEKQQQQQHQQRHNRDRDRDGNG 509
            |   .|.|...  ..||.....||:.::              |...|::...:.|:       |.
  Fly   829 M---PNTSYPTHPRHSLYGVTAEEINQKPIQRAPLMGANARVKMPSQERYGTRPHS-------NH 883

  Fly   510 NVDRQLTGHNGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAG 574
            .:...:| .:|:.....:.||.:.:|..|.:..:|..          |.|.....||:..|||
  Fly   884 RLSLNIT-PSGDFYQPKTSGQQAQQQVMNASSTSAGF----------GVGSGSMVGGTGPAAG-- 935

  Fly   575 GDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSL----ADRSLY----GREMSLLRVKNGG 631
                     ||....|::: :.||......:|.|.:..    ..|..:    |:...::.:|:..
  Fly   936 ---------EFPVRKQQVY-DVFHPPPLPKNSSGSNMFMPLHPTRGSHPPPVGQPPDVVSLKSQN 990

  Fly   632 SGGGEGSGVMPTMRPVSMGRPLVTMSTYQER--GETLKRTSIMPDESCYRNSINSNNNNGFSRNR 694
            |.....|...|.:....|         |.:|  .:.::.....|.:|   .||.|..:.|:....
  Fly   991 SIESILSAKSPAISEYGM---------YAKRHVPQAVRHVPKYPSDS---ESIGSGVHGGYGGFL 1043

  Fly   695 SNSNTNNNNRLQSQNGVNP---ANGNGSP-ELPPPPPQ--------------------------F 729
            .:::...|...|......|   .|...|| .||.||||                          .
  Fly  1044 QSNHMPGNRHTQLFPTFGPGGRGNRRSSPLTLPSPPPQQQLQQLPAATAPHDSVGIPTDLDYHPH 1108

  Fly   730 ANPQPKQMPPQHIKPMTGNAAANGSGSANGLGNGSLAKVRQPMSPMRSASISVGGF--------- 785
            .:.|...||..|..|   :|.....|  :|||.|....|...:|.:..|....|.|
  Fly  1109 HHTQTNAMPHPHPHP---HAPYLDYG--HGLGIGPYMGVGGGVSGVGGAIYEGGTFPRKKDNQRL 1168

  Fly   786 RPPATPQ-PDYDAVQIRSSQGS---------ESVSGRDVATSQQQRRTLRLGTVTI-GEYGDQRT 839
            |.|:.|. ....:..:::|.||         ..|||..::.|...|..:.|.:.:| ..||....
  Fly  1169 RIPSNPSVASKSSSMVKNSSGSIDHHYVTSTGPVSGGSMSASSSDRAPMSLMSSSIHNSYGANIA 1233

  Fly   840 TGKRETLRKTNGEPASNGILKNGSNRS 866
            .|        ||..:|.|:...|...|
  Fly  1234 GG--------NGTGSSIGVGGGGGGGS 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	19/69 (28%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	20/80 (25%)
Dlg5	NP_609505.1	AAA_23	<165..333	CDD:290211
		CENP-F_leu_zip	229..360	CDD:287450
		DUF1090	<326..408	CDD:284007	8/46 (17%)
		PDZ_signaling	439..516	CDD:238492	22/94 (23%)
		PDZ_signaling	533..592	CDD:238492	17/64 (27%)
		PDZ_signaling	1290..1369	CDD:238492
		PDZ_signaling	1497..1576	CDD:238492
		SH3_DLG5	1594..1657	CDD:212794
		Guanylate_kin	1737..1904	CDD:279019
		NK	<1773..1905	CDD:302627
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810