DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Pdzd7

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001099832.2	Gene:	Pdzd7 / 293996	RGDID:	1309882	Length:	1031	Species:	Rattus norvegicus

Alignment Length:	999	Identity:	218/999 - (21%)
Similarity:	348/999 - (34%)	Gaps:	298/999 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GSTTSSASSDVMTLTTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGGPERG------------- 82
            |..:|::.|.:.:.....:.|     ||:..|.  |:|..||  |:.||.||
  Rat    15 GELSSASLSSLSSRGHLGSDS-----ASTATRY--LLRKQQR--LLNGPSRGIRASSPMGRVILI 70

  Fly    83 ------------------------STYGFTVRGGREHGTGFFVSHVEHGGEAHLKGLRIGDQILR 123
                                    ...||:||||.|||.|.|||.||.|..|...||.:||:|..
  Rat    71 NSPIEANSDESDIIHAVCVEKSPSGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLCVGDKITE 135

  Fly   124 INGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSW-SVVK----LPSVSGTPSE 183
            :||..|:.......::|:....|:.:.||.:|.:|.....:|:.:| .||.    :...|.|||:
  Rat   136 VNGLSLESTTMGSAVRLLTSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCSSTPSD 200

  Fly   184 SSFK-GERRGASRDISVVLHVAPRTK---LGLGICKGPEWKPGIFVQFTKDRSVAREAGLRPGDQ 244
            ||.: |.||        ::|:...:.   ||..|..|.|:..||:|.......:|.|.|::.|||
  Rat   201 SSSEDGVRR--------IVHLYTTSDDFCLGFNIRGGKEFGLGIYVSKVDHGGLAEENGIKVGDQ 257

  Fly   245 ILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPGESSGYNSSASSVTGDQSPCWADA 309
            :|:.|.:.|.|:..|:||.|:|..:.:.:.::..       |....|....|..      ||.|.
  Rat   258 VLAANGVRFDDISHSQAVEVLKGQTHIMLTIKET-------GRYPAYKEMVSEY------CWLDR 309

  Fly   310 KS----KRLTAVREESG-----AGGGGCGLSSAPG-------------AGSPNWSQ---GVEVHK 349
            .|    ::|:...|.|.     |....|...|.|.             :..|.|.:   .::...
  Rat   310 LSNGVLQQLSPASESSSSVSSYASSAPCSSGSLPSDRMDVCLGPEDPTSQGPGWGRADTAMQTEP 374

  Fly   350 QMNKTIIKLTENGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQ-------SNPSNPSRNST 407
            .|..:.:   |...|:..|.|.........|..||....|..|:..:       |.|..|    .
  Rat   375 DMGGSRV---ETWCSVRPTVILRDTAIRSDGPSSTRHLDSALSESPKTALLLALSRPRPP----I 432

  Fly   408 TMKRSHLRPVNSAGSGIGLSSGSAGSAGSAGSS-----------------GSGSRSGGVI-APAP 454
            |..:|||.............|||:|..|:...|                 |.|.|....: :.:|
  Rat   433 TRSQSHLTLWEEKKQRKKEKSGSSGEKGALQRSKTLMNLFFKGGRQGRPAGDGHREAWTLDSRSP 497

  Fly   455 APPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNG-NVDRQLTGH 518
            ....|.::  ...:|||| .:...:|..|::.:|:.:.....    |.....|.| |||.|:
  Rat   498 TKVRPRLD--LEKAGSVG-PVQKFVTWRLRRDRERGRALLSA----RSGSPSGQGPNVDEQM--- 552

  Fly   519 NGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAGGDQHTALMD 583
                       |....:|..:..:|..|...:.:..:|                    :|.:
  Rat   553 -----------QAWESRRPLIQDLARRLLTDDEVLAVT--------------------RHCS--- 583

  Fly   584 EFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVMPTMRPVS 648
              :..|           |..:..|.:..||   :..|...||.:::          :...:.|..
  Rat   584 --RYVH-----------EGGVEDLVRPLLA---ILDRPAKLLLLRD----------IRSVVAPTD 622

  Fly   649 MGR-PLVTMSTYQERGETLKRTSIMP--------DESCYRNSIN--SNNNNGFSRNRSNSNTNNN 702
            :|| ..:.|....|..|.||..::.|        |....|:.|.  .::..||.....||.:.:.
  Rat   623 LGRFDSMVMPVEMEAFEALKSRAVGPSALRPTRQDTPPKRHLITPVPDSRGGFYLLPVNSCSEDE 687

  Fly   703 N--------RLQSQNGVNPANGNGSPEL----------------PPPPPQFANPQPKQ------M 737
            :        .|:...|.:..:..|.|.|                |||.|....|:|.:      .
  Rat   688 DGEIRERLGGLKVSLGASAPHHKGIPPLQDVPVDAFSLRRGACAPPPQPPPVAPRPPRPNWLLTE 752

  Fly   738 PP------QHIKPMTGNAAANG-------SGS---ANGLGNGSLAKVRQPMS--PMRSASISVGG 784
            ||      |:.....|.:.:..       |||   :...|.|..|..|:..|  |:.:|:.:.|.
  Rat   753 PPSREDTQQNQNQTPGQSCSRSRSHSRSRSGSRSRSRSQGRGKSAGCRRSPSPAPITTATSANGR 817

  Fly   785 F-RP----PATPQP---DYDAVQIRS-------SQGSESVSGRDVATSQQQRRTLRLGTVTIGEY 834
            : ||    |..|:|   ....|.:|.       .|.:|..:|.  ||:.:.|      |||:.:
  Rat   818 YHRPRKARPLLPRPLDGQVAKVGVRQEPLENGIDQTAEDEAGN--ATTGELR------TVTLSK- 873

  Fly   835 GDQRTTGKRETLRKTNGEPASNGI 858
                       ::::.|...|.||
  Rat   874 -----------MKQSLGISISGGI 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	28/106 (26%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	24/81 (30%)
Pdzd7	NP_001099832.2	PDZ_signaling	84..164	CDD:238492	27/79 (34%)
		PDZ_signaling	209..289	CDD:238492	25/87 (29%)
		HN_PDZD7_like	555..632	CDD:259824	16/125 (13%)
		PDZ_signaling	866..954	CDD:238492	8/39 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9173
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820