DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Mpdz

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus

Alignment Length:	1183	Identity:	223/1183 - (18%)
Similarity:	349/1183 - (29%)	Gaps:	456/1183 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTNSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGGPER 81
            ||..:|  ..|..:..|..|.|.:....|.|.|..
  Rat   969 LTEQSS--LVSDAESVTLQSMSQEAFERTVTIAKG------------------------------ 1001

  Fly    82 GSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVHKEFIQLVAGQD 145
            .|:.|.||...:: |.|..|..:.|||.....| :.:||.||.||        .:..|.|...|.
  Rat  1002 SSSLGMTVSANKD-GLGVIVRSIIHGGAISRDGRIAVGDCILSIN--------EESTISLTNAQA 1057

  Fly   146 RVTLKVRG---------------------VGMLPVRDLPEERLSW-------------------S 170
            |..|:...                     :..:|...|.|.|:|:                   .
  Rat  1058 RAMLRRHSLIGPDIKFSAAPADDRAPFYVITYVPAEHLEEFRVSFGQQAGGIMALDIFSSYTGRD 1122

  Fly   171 VVKLP---SVSGTPSE------SSFKGERRGASRDISVVLHVAPRTKLGLGICKG---------P 217
            :.:||   ...|..||      ||:...||       |.|...|...||:.|..|         .
  Rat  1123 IPELPEREEGEGEESELQNAAYSSWSQPRR-------VELWREPSKSLGISIVGGRGMGSRLSNG 1180

  Fly   218 EWKPGIFVQFTKDRSVAREAG-LRPGDQILSVNSIDFSDVLFSEAV-AVMKSSSKLDMVVRTAAG 280
            |...|||::...:.|.|.:.| |:|||:|:.|:.:|..|....:|| |:.|:.|.:..:|::...
  Rat  1181 EVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGSPVVFMVQSIVN 1245

  Fly   281 -----------CDLFPGES-SGYNSSASS--VTGDQSPCWADAKSKRLTAVREESGAGGGGCGLS 331
                       ..|:|..| |..|..|.|  :|.|::|..::::|::.|              |.
  Rat  1246 RPRKSPLPSLPHSLYPKCSFSSTNPFAESLQLTSDKAPSQSESESEKAT--------------LC 1296

  Fly   332 SAPGAGSPNWSQGVEVHKQMNKTII-----KLTENGTSINNTYIASTGGSSVSGSGSTGSGTSGR 391
            |.|.:....:|:....:.|.:.|.:     |..|.|.|..|.
  Rat  1297 SVPSSSPSVFSEMSSDYAQPSATTVAEDEDKEDEFGYSWKNI----------------------- 1338

  Fly   392 SQQSQSNPSNPSRNSTTMKRSHLRPVNSAGSGIGLSSGSAGS---------------AGSAGSSG 441
                      ..|..|...:.|:..:....||:|||  .||:               .|:||..|
  Rat  1339 ----------QERYGTLTGQLHMIELEKGHSGLGLS--LAGNKDRTRMSVFIVGIDPTGAAGRDG 1391

  Fly   442 -------------------SGSRSGGVIAPAPAP-------PPPAMNEGANASGSVGSSLSSAIT 480
                               |...:..:|..||:.       ...|:|:.|...||....|.|  |
  Rat  1392 RLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFIRNADAVNQMAVCPGSAADPLPS--T 1454

  Fly   481 EELKKRKEKQ------------QQQQHQQRHNRDRDRDG-----------NGNVDRQLTGHNG-- 520
            .|..:.||.:            ....:.......:|:.|           ||...:.||...|
  Rat  1455 SESPQNKEVEPSITTSASAVDLSSLTNVYHLELPKDQGGLGIAICEEDTLNGVTIKSLTERGGAA 1519

  Fly   521 ----------------------------------------------------------NGGHRSS 527
                                                                      ..|.|..
  Rat  1520 KDGRLKPGDRILAVDDELVAGCPIEKFISLLKTAKTTVKLTVGAENPGCQAVPSAAVTASGERKD 1584

  Fly   528 VGQ-----------VSHRQRANVAGVAAT-------LQGSE---RISNLTGGGGAGGAGGSNGAA 571
            ..|           :....|::...:.|:       :.|.|   .||....|.|....|||:...
  Rat  1585 SSQTPAVPAPDLEPIPSTSRSSTPAIFASDPATCPIIPGCETTIEISKGQTGLGLSIVGGSDTLL 1649

  Fly   572 GA-------------------GGDQ-------------HTALMDEFKRAHQR----MFRNGFHES 600
            ||                   .|||             |...::..::..||    ::|:.....
  Rat  1650 GAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYK 1714

  Fly   601 EHKLSSLGKSSLADRSLYGREMSLLRVKN-----------GGSGGGEGSGVMPTMRPVSMGRPLV 654
            |..:.......|..|...|..:|::..:|           ||....:|.        :..|..::
  Rat  1715 EEDVCDTFTVELQKRPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGR--------LMQGDQIL 1771

  Fly   655 TMSTYQERGETLKRTSIM-------------------------PDESCYRNSINSNNNNGFSRNR 694
            .::....|..|.:..:.:                         |.:|   :.::.::.:.||..|
  Rat  1772 MVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIKAAPFHSERRPSQS---SQVSESSLSSFSLPR 1833

  Fly   695 SNSNTNNN-------NRLQSQ----------------NGVNPANGNGSPELPPPPPQFANPQPKQ 736
            |..:|:.:       |.|.|:                .|::.|.|.||| |...|...|...|..
  Rat  1834 SGIHTSESSESSAKKNALASEIQGLRTVEIKKGPADALGLSIAGGVGSP-LGDVPIFIAMMHPNG 1897

  Fly   737 MPPQHIKPMTGNAAANGSG-SANGLGNGSLAKVRQPMSPMRSASISV------GGFRPPATPQPD 794
            :..|..|...|:......| |.:|:.:      .|.::.|::||.|:      ||.....|....
  Rat  1898 VAAQTQKLRVGDRIVTICGTSTDGMTH------TQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQ 1956

  Fly   795 YDAVQIRSSQG--SESVSGRDVATSQQQRRTL-----RLGTVTIGEYGDQRTTGKRETLRKT--- 849
            ..|....:..|  |.::...|:...|.:..||     .||...:|.||...  |......||
  Rat  1957 ELANPCLAFTGLTSSTIFPDDLGPPQSKTITLDRGPDGLGFSIVGGYGSPH--GDLPIYVKTVFA 2019

  Fly   850 NGEPASNGILKNG 862
            .|..|.:|.||.|
  Rat  2020 KGAAAEDGRLKRG 2032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	22/70 (31%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	27/89 (30%)
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		PDZ	374..463	CDD:214570
		PDZ_signaling	552..621	CDD:238492
		PDZ_signaling	693..776	CDD:238492
		PDZ_signaling	993..1063	CDD:238492	25/108 (23%)
		PDZ_signaling	1150..1241	CDD:238492	29/97 (30%)
		PDZ	1348..1433	CDD:214570	16/86 (19%)
		PDZ_signaling	1482..1561	CDD:238492	7/78 (9%)
		MPDZ_u10	1563..1624	CDD:293272	5/60 (8%)
		PDZ	1625..1709	CDD:214570	16/83 (19%)
		PDZ_signaling	1721..1801	CDD:238492	11/87 (13%)
		PDZ_signaling	1858..1943	CDD:238492	21/91 (23%)
		PDZ_signaling	1984..2067	CDD:238492	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810