DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and WHRN

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_011516787.1	Gene:	WHRN / 25861	HGNCID:	16361	Length:	918	Species:	Homo sapiens

Alignment Length:	885	Identity:	189/885 - (21%)
Similarity:	300/885 - (33%)	Gaps:	264/885 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 PASSR-LRVLRLVRPHQRRLLV---------------------GGPE-------------RGSTY 85
            |...| |.:||||.|...:||.                     |||:             |...:
Human    85 PVKRRLLPMLRLVIPRSDQLLFDQYTAEGLYLPATTPYRQPAWGGPDSAGPGEVRLVSLRRAKAH 149

  Fly    86 ---GFTVRGGREHGTGFFVSHVEHGGEAHLKGLRIGDQILRINGFRLDDAVHKEFIQLVAGQDRV 147
               ||::|||.|||.|.:||.||.|..|..:|||:||||||:|...|....|.|.::.:.|..::
Human   150 EGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKL 214

  Fly   148 TLKVRGVGMLPVRDLPEERLSWSVVKLPSV---SGTPSE-----SSFKGERR--------GASRD 196
            .|.|...|.:|...:.....:|...:..|:   ||.|..     ...:|:||        |..:.
Human   215 VLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSGLPQPHGGALRQQEGDRRSTLHLLQGGDEKK 279

  Fly   197 ISVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAREAGLRPGDQILSVNSIDFSDVLFSEA 261
            :::||  .....|||.|..|.|:..||::......|.|..:||:.|||||.||...|.::|..||
Human   280 VNLVL--GDGRSLGLTIRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEA 342

  Fly   262 VAVMKSSSKLDMVVRTAAGCDLFPGESSGYNSSASSVTGDQSPCWADAKSKRLTAVREESGAGGG 326
            |.::|||..|.:.|:...            ....:..|.|::...|.::      :||......|
Human   343 VRLLKSSRHLILTVKDVG------------RLPHARTTVDETKWIASSR------IRETMANSAG 389

  Fly   327 GCGLSSAPGAGSPNWSQG-----VEVHKQMNKTIIKLTENGTSINNT--------YIASTGGSSV 378
            ..|..:..|...|.:.:|     |.:....|:|.:.|.|....:.|.        |:....|.||
Human   390 FLGDLTTEGINKPGFYKGPAGSQVTLSSLGNQTRVLLEEQARHLLNEQEHATMAYYLDEYRGGSV 454

  Fly   379 SGSG---------STGSGTSGRSQ-QSQSNPSNPSRNSTTMKRSHLR-------PVNSAG----- 421
            |...         :|.:..|..|: :...:|.:..|....:.|..:.       |...||
Human   455 SVEALVMALFKLLNTHAKFSLLSEVRGTISPQDLERFDHLVLRREIESMKARQPPGPGAGDTYSM 519

  Fly   422 ---SGIGLSSGSAGSAGSAGS--------------------SGSG-----------------SRS 446
               |..|.|:||.|::.:..|                    :|..                 |.|
Human   520 VSYSDTGSSTGSHGTSTTVSSARERLLWLIDLMENTLDLEETGEAVQGNINALPDVSVDDVRSTS 584

  Fly   447 GGVIAPAPAPPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRDRDRDGNGNV 511
            .|:.:..|.|.||.:.:|.:.          .:.:..|..:|..|......
Human   585 QGLSSFKPLPRPPPLAQGNDL----------PLGQPRKLGREDLQPPSSMP-------------- 625

  Fly   512 DRQLTGHNGNGGHRSSVGQV--SHRQRANVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAG 574
                          |..|.|  :.:.|:..||.|.| .|:....:|...........:|.::...
Human   626 --------------SCSGTVFSAPQNRSPPAGTAPT-PGTSSAQDLPSSPIYASVSPANPSSKRP 675

  Fly   575 GDQHTALMDE-----FKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGG 634
            .|.|.||:::     |.|.         ....|..|...::::|...|         :....||.
Human   676 LDAHLALVNQHPIGPFPRV---------QSPPHLKSPSAEATVAGGCL---------LPPSPSGH 722

  Fly   635 GEGSGV-----------------MPTMRPVSMGRPLVTMSTYQERGETLKRTSIMPDESCYRNSI 682
            .:.:|.                 :..:|.:...|...|:|...:.|:||...|          .:
Human   723 PDQTGTNQHFVMVEVHRPDSEPDVNEVRALPQTRTASTLSQLSDSGQTLSEDS----------GV 777

  Fly   683 NSNNNNGFSRNRSNSNTNNNNRLQSQNGVNPANGNGSPELPPPPPQFANPQP---KQMPPQHIKP 744
            ::......:..|...:.:..:|             .|.|||      .|.:|   ...||..::|
Human   778 DAGEAEASAPGRGRQSVSTKSR-------------SSKELP------RNERPTDGANKPPGLLEP 823

  Fly   745 MTGNAAANGSGSANGLGNGSLAKVRQPMSPMRSASISVGG 784
            .:.......|.:..|:.....|..|||:.  |..:|..||
Human   824 TSTLVRVKKSAATLGIAIEGGANTRQPLP--RIVTIQRGG 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	30/72 (42%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	30/78 (38%)
WHRN	XP_011516787.1	HN_L-whirlin_R1_like	37..112	CDD:259822	10/26 (38%)
		PDZ_signaling	138..215	CDD:238492	30/76 (39%)
		PDZ_signaling	277..357	CDD:238492	30/81 (37%)
		HN_L-whirlin_R2_like	419..499	CDD:259823	16/79 (20%)
		PDZ_signaling	827..898	CDD:238492	10/37 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D168224at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820