DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and X11L

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001285376.1	Gene:	X11L / 252671	FlyBaseID:	FBgn0026313	Length:	1170	Species:	Drosophila melanogaster

Alignment Length:	751	Identity:	147/751 - (19%)
Similarity:	231/751 - (30%)	Gaps:	248/751 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 TPSESSFKGERRGASRDISVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAREAGLRPGDQ 244
            ||.|.::.|:|          |...|:.:|.: :.:.|..||                   |.||
  Fly   321 TPMEQAYIGQR----------LARIPKDELYM-VHRSPTKKP-------------------PSDQ 355

  Fly   245 --------------ILSVNSIDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLFPGESSGYNSSA 295
                          .:..||....|:..:|..|.::..|:         ...|.| |::.|:|:.
  Fly   356 NPSTAYQEHNDIELYIDSNSRSSGDLADTELEANLRRHSR---------NFTLSP-ETTDYDSNC 410

  Fly   296 ---SSVTGDQSPCWAD-AKSKRLTAVREESGAGGGGCGLSSAPGAGSPN----------WSQGVE 346
               .|::.|.: |..| .|......|.|:        ||||...:.:.|          .||...
  Fly   411 GDLDSLSNDIN-CPTDFGKLYTSMPVLED--------GLSSGHASDTENNVSVVCDKQQSSQSQP 466

  Fly   347 VHKQMNKTIIKLTENGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQSN------------P 399
            ||:.        ..||..:.|.|...        |.|..:.|:..||.:..:            |
  Fly   467 VHEH--------NGNGERLENDYNVM--------SASLATLTTDASQSALISDFASLPMPPAPPP 515

  Fly   400 SNP-------SRNSTTMKRSHLRPVN------------------SAGSGIGLSSGSAGSAGSAGS 439
            |:|       :..|.||......|::                  |||||:|::..:||  ||..|
  Fly   516 SSPPQIEIADASESMTMVPDADNPLDSHYGAVYAAALGGTHTEKSAGSGLGVTPVTAG--GSLPS 578

  Fly   440 SGSGS--------RSG---------------GVIAPAPAPPPPAMNEGANASGSVGSSLSSAITE 481
            ..:..        ||.               .|:...|..|.....:|...|.:.|::.......
  Fly   579 QAASEIQEAMKEIRSALQRAKTQPEKLKFCDEVLPTDPDSPVWVPRKGTTISTAQGAAADEEPDT 643

  Fly   482 ELKKRKEKQQQQQHQQRHNRDR---DRDGNGNVDRQLTGH-NG----------NGGHRSSVGQVS 532
            :|:..:...||:..:|....|:   |.:.|...|....|| ||          |.....:....:
  Fly   644 DLETDRLLGQQRHDEQDFFADQSLADNNANEGTDIASNGHLNGTSDNNNPNPMNNSKPQTYSTAT 708

  Fly   533 HRQRANVAGVAATL-QGSERISNLTG-------------------GGGAGGAGGSNGAAGAGGDQ 577
            .||     |:..:| ..|..|..:.|                   |........:|....|....
  Fly   709 IRQ-----GIGTSLTPNSPDICQIVGTTDISISSPEKLQFTKSPTGSIKSLKDSANSDKKAKSRN 768

  Fly   578 HTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVMP 642
            ...|::........:||..:..|. :|...|:.:.:.|.:...| ::.|:|   :...||.....
  Fly   769 KEGLLEPKVLIEGVLFRARYLGST-QLVCEGQPTKSTRMMQAEE-AVSRIK---ALAPEGESQPS 828

  Fly   643 T-----------------MRPVSMGRPLVTMSTYQERGETLKRTSIMPDESCYRNSINSNNNNGF 690
            |                 ::.:.|...|.|:|...:.|:.:..                     .
  Fly   829 TEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVL---------------------M 872

  Fly   691 SRNRSNSNTNNNNRLQSQNGVNPANGNGSPELPPPPP-QFANPQPKQM-------PPQHIKPMTG 747
            :|.|...|:..:..:.|..|..|..|.|..|.||..| ...|..||.:       ..|.|....|
  Fly   873 ARRRFVPNSVVDPSITSPLGDVPTPGIGEEESPPKEPLSKHNRTPKMICHVFESDEAQFIAQSIG 937

  Fly   748 NA---AANGSGSANGLGNGSLAKVRQPMSPMRSASI 780
            .|   |......|||:.|.||||.......:.|..|
  Fly   938 QAFQVAYMEFLKANGIENESLAKEMDYQEVLNSQEI 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	15/92 (16%)
X11L	NP_001285376.1	PTB_X11	775..954	CDD:269919	40/204 (20%)
		PDZ_signaling	988..1065	CDD:238492
		PDZ_signaling	1092..1151	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900