DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and PDZD2

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	XP_005248326.1	Gene:	PDZD2 / 23037	HGNCID:	18486	Length:	2873	Species:	Homo sapiens

Alignment Length:	1229	Identity:	246/1229 - (20%)
Similarity:	391/1229 - (31%)	Gaps:	442/1229 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTNSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRLRVLRLVRPHQRRLLVGGPER 81
            |.:|:|......:...:|.|.|      ||...|.|            ||:||....::....|:
Human   547 LLDSSSASQEYHIVKKSTRSLS------TTQVESPW------------RLIRPSVISIIGLYKEK 593

  Fly    82 GSTYGFTVRGGRE--HG-TGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRL-----DDAVHKEF 137
            |...||::.|||:  .| .|.||..:...|.|...| |:.||:||.:||..:     .:|:| .|
Human   594 GKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIH-TF 657

  Fly   138 IQLVAGQDRVTLKVRGVGMLPVRDLPEERLSWSVVKLPSVSGTPS-------ESSFKGERRGASR 195
            .|:.:|...:|::.:.|............:|.|.....:.||..|       .||..|.:....:
Human   658 KQIRSGLFVLTVRTKLVSPSLTPCSTPTHMSRSASPNFNTSGGASAGGSDEGSSSSLGRKTPGPK 722

  Fly   196 D---ISVVLHVAPRTKLGLGIC-----KGPEWKPGIFVQFTKDRSVAR-EAGLRPGDQILSVNSI 251
            |   :.|.|:..||..||:|.|     ..|   |||::......|||: |:.|..|||||.|||:
Human   723 DRIVMEVTLNKEPRVGLGIGACCLALENSP---PGIYIHSLAPGSVAKMESNLSRGDQILEVNSV 784

  Fly   252 DFSDVLFSEAVAVMK-------------------SSSKLDMVVRTAA-------------GCDL- 283
            :......|:..|::.                   |..::|.|:..:.             |..|
Human   785 NVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESKEANSSPGLGTPLK 849

  Fly   284 -----------------------FPGESSGY------------NSSASSVTGDQSPCWADAKS-- 311
                                   .||..|.:            :..::|..|...|..:..|.
Human   850 SPSLAKKDSLISESELSQYFAHDVPGPLSDFMVAGSEDEDHPGSGCSTSEEGSLPPSTSTHKEPG 914

  Fly   312 --------------------KRLTAVREESGAGG------------------------------- 325
                                |::|..|:.|..|.
Human   915 KPRANSLVTLGSHRASGLFHKQVTVARQASLPGSPQALRNPLLRQRKVGCYDANDASDEEEFDRE 979

  Fly   326 GGCGLSSAPGA---------------GSPNWSQGVEVHKQ---MNKTIIKLTEN----GTSIN-- 366
            |.|  .|.|||               .|.:.|:|::||.|   ..||::....:    |:|::
Human   980 GDC--ISLPGALPGPIRPLSEDDPRRVSISSSKGMDVHNQEERPRKTLVSKAISAPLLGSSVDLE 1042

  Fly   367 ----------NTYIASTGGSSVSGSGSTG-------SGTSGRSQ---------QSQSN---PSNP 402
                      .:|.|:...|:.:..||.|       ||:|...:         ||.:|   ||:|
Human  1043 ESIPEGMVDAASYAANLTDSAEAPKGSPGSWWKKELSGSSSAPKLEYTVRTDTQSPTNTGSPSSP 1107

  Fly   403 SRNSTTMKRSHLRPVNSAGSGIGLSSGSAGSAGS-----AGSSG------------------SGS 444
            .:.|..:...| |||.........|...|..:||     .|.:.                  :|.
Human  1108 QQKSEGLGSRH-RPVARVSPHCKRSEAEAKPSGSQTVNLTGRANDPCDLDSRVQATSVKVTVAGF 1171

  Fly   445 RSGGVIAPAPAPPPPAMNEGANASGSVGSSLS----SAITEELKKRKEKQQQQQHQQRHNRDRDR 505
            :.||.:...........:...:.|..:.|:||    |.:||.|.|...:..||...:   .|...
Human  1172 QPGGAVEKESLGKLTTGDACVSTSCELASALSHLDASHLTENLPKAASELGQQPMTE---LDSSS 1233

  Fly   506 DGNGNVDRQLTGHNGNGGHRSSVGQVSHRQ----------------------------------- 535
            |...:..::...|..........||||..:
Human  1234 DLISSPGKKGAAHPDPSKTSVDTGQVSRPENPSQPASPRVTKCKARSPVRLPHEGSPSPGEKAAA 1298

  Fly   536 -----RANVAGVAATLQGSERISNLTGGGGAGGAGGSNGAAGAG----GDQHTALMDEFKRAHQR 591
                 :...|...:|...:.|::.|.|.|     .|:.|...||    ||..|:       ..||
Human  1299 PPDYSKTRSASETSTPHNTRRVAALRGAG-----PGAEGMTPAGAVLPGDPLTS-------QEQR 1351

  Fly   592 MFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGGSGGGEGSGVMPTMRP-VSMGRPLVT 655
            ....|.|....:::.:.    |..|  .:|.|||          ||:..:.:..| .|:.....|
Human  1352 QGAPGNHSKALEMTGIH----APES--SQEPSLL----------EGADSVSSRAPQASLSMLPST 1400

  Fly   656 MSTYQERGETL-------KRTSIMPDESCYRNSINSNNNNGFSRNRSNSNTNNNNRLQSQNGVNP 713
            .:|.:..|...       .|.|.:.|...:...::::    .:|:.|:...::.::..|..|..|
Human  1401 DNTKEACGHVSGHCCPGGSRESPVTDIDSFIKELDAS----AARSPSSQTGDSGSQEGSAQGHPP 1461

  Fly   714 ANGNG---------------SPEL-----PPPPPQFANPQPKQM----PPQHI---KPMTGNAAA 751
            |...|               ||..     .|..||:|: ||..:    |.:|.   |....|.:.
Human  1462 AGAGGGSSCRAEPVPGGQTSSPRRAWAAGAPAYPQWAS-QPSVLDSINPDKHFTVNKNFLSNYSR 1525

  Fly   752 N------GSGSANGLGNGS-------------------------LAKVRQPMSPMRS-------- 777
            |      .|.|.:|||:.:                         .|..|...||.||
Human  1526 NFSSFHEDSTSLSGLGDSTEPSLSSMYGDAEDSSSDPESLTEAPRASARDGWSPPRSRVSLHKED 1590

  Fly   778 ------ASISVGGFR----PPATPQ--PDYDAV--------QIRSSQGSESVSGRDVATSQQQRR 822
                  ..|.:...|    ||::|.  |...|:        .::.|...|||:      |.:::.
Human  1591 PSESEEEQIEICSTRGCPNPPSSPAHLPTQAAICPASAKVLSLKYSTPRESVA------SPREKA 1649

  Fly   823 TLRLGTVTIGEYGDQRTTGKRETLRKTNGEPASNGILKNGSNRSSASFNHGSSHQTEKT 881
            ....|:.|.|....|.::    .|..::.|..::..:       |.|.||..|...|.|
Human  1650 ACLPGSYTSGPDSSQPSS----LLEMSSQEHETHADI-------STSQNHRPSCAEETT 1697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	26/78 (33%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	30/103 (29%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	589..670	CDD:238492	27/81 (33%)
		PDZ_signaling	726..810	CDD:238492	27/86 (31%)
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900