DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5921 and dlg-1

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001024431.1	Gene:	dlg-1 / 180819	WormBaseID:	WBGene00001006	Length:	967	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	107/464 - (23%)
Similarity:	180/464 - (38%)	Gaps:	84/464 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GSTTSSASSDVMTLTTTAASSWCAI--PAS---------------SRLRV--LRLVRPHQRRL-L 75
            |.:||...|.| |.:.:|.:...||  |::               |:|.|  .|..||:...: |
Worm   301 GGSTSYLRSGV-TPSVSAGNLQHAIHSPSAPIHPPPPPPVHHGSLSQLSVGQYRSTRPNTSVIDL 364

  Fly    76 VGGPERGSTYGFTVRGGR--EH---GTGFFVSHVEHGGEAHLKG-LRIGDQILRINGFRLDDAVH 134
            |.| .||  .||::.||:  ||   .|..:|:.:...|.|.|.| ||:||:||.::...|.:..|
Worm   365 VKG-ARG--LGFSIAGGQGNEHVKGDTDIYVTKIIEEGAAELDGRLRVGDKILEVDHHSLINTTH 426

  Fly   135 KEFIQLVAGQ-DRVTLKV-RGVGMLPVRDLPEERLSWSVVKLP--------SVSGTPSESSFKGE 189
            :..:.::... :||.|.: :|.|.:......::.:..:.:..|        |..|:.|..|:.|.
Worm   427 ENAVNVLKNTGNRVRLLIQQGTGAIFNDSASQQFMPTTPILRPSSVQDYNRSQMGSQSHLSYGGP 491

  Fly   190 -RRGASRDISVVLHVAPR--------TKLGLGICKGPEWKPGIFVQFTKDRSVAREAG-LRPGDQ 244
             ....|....:.:.:.||        ..||..|..|.:.:| |::.|.....||..:| ::.||.
Worm   492 LNTSYSSQAPIAIPLEPRPVQLVKGQNGLGFNIVGGEDNEP-IYISFVLPGGVADLSGNVKTGDV 555

  Fly   245 ILSVNSIDFSDVLFSEAVAVMKSSSK---LDMVVRTAAGCDLFPGESSGYNSSASSVTGD---QS 303
            :|.||.:...:....||...::::..   |.:..|        |.|...:.|....:..|   ||
Worm   556 LLEVNGVVLRNATHKEAAEALRNAGNPVYLTLQYR--------PQEYQIFESKIEKLRNDVIAQS 612

  Fly   304 PCWA-DAKSKRLTAV------REESGAGGGGCGLSSAP-----GAGSPNWSQGVEVHKQMNKT-- 354
            .... ..||:.:.|:      ||.|.|.....|.:...     .:....|....:||:...:|
Worm   613 RMGTLSRKSEYVRALFDYDPSRENSVAPHRSMGFNYGDILHIINSSDDEWWTARKVHENGEETAE 677

  Fly   355 -II---KLTENGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQSNPSNPSRNSTTMKRSHLR 415
             :|   |..|....:....:....||...|..|:.:|...| :.|:|..|...:.........|.
Worm   678 GVIPSKKRVEKRERLRRKQVNFNSGSQSLGRNSSTTGLENR-RGSRSQLSFSRKFPFVKSTDRLN 741

  Fly   416 PVNSAGSGI 424
            .:|...|.:
Worm   742 DLNEESSNV 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	24/77 (31%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	20/90 (22%)
dlg-1	NP_001024431.1	L27_1	7..63	CDD:312556
		PDZ	199..289	CDD:214570
		PDZ_signaling	361..445	CDD:238492	28/86 (33%)
		PDZ	507..591	CDD:214570	21/92 (23%)
		SH3_DLG-like	623..684	CDD:212795	11/60 (18%)
		GuKc	776..944	CDD:214504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910