DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Mpdz

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001292213.1	Gene:	Mpdz / 17475	MGIID:	1343489	Length:	2069	Species:	Mus musculus

Alignment Length:	1183	Identity:	233/1183 - (19%)
Similarity:	361/1183 - (30%)	Gaps:	429/1183 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ASISTS-----------ASLTNSASTDCSSSMQGSTTSSASSDVMTLTTTAASSWCAIPASSRLR 62
            :|:|||           ..||:.:|  .:|..:.....|.|.:....|.|.|..
Mouse   951 SSLSTSELAPALPAVAQKYLTDQSS--LASDAESVNLQSMSQEAFERTVTIAKG----------- 1002

  Fly    63 VLRLVRPHQRRLLVGGPERGSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKG-LRIGDQILRING 126
                               .|:.|.||...:: |.|..|..:.|||.....| :.:||.||.||
Mouse  1003 -------------------SSSLGMTVSANKD-GLGVIVRSIIHGGAISRDGRIAVGDCILSIN- 1046

  Fly   127 FRLDDAVHKEFIQLVAGQDRVTLKVRG---------------------VGMLPVRDLPEERLSW- 169
                   .:..|.|...|.|..|:...                     :..:|...|.|.|:|:
Mouse  1047 -------EESTISLTNAQARAMLRRHSLIGPDIKFSAAPADDRAPFYVITYVPAEHLEEFRVSFG 1104

  Fly   170 ------------------SVVKLP---SVSGTPSE------SSFKGERRGASRDISVVLHVAPRT 207
                              .:.:||   ...|..||      ||:...||       |.|...|..
Mouse  1105 QQAGGIMALDIFSSYTGRDIPELPEREEGEGEESELQNAAYSSWSQPRR-------VELWREPSK 1162

  Fly   208 KLGLGICKG---------PEWKPGIFVQFTKDRSVAREAG-LRPGDQILSVNSIDFSDVLFSEAV 262
            .||:.|..|         .|...|||::...:.|.|.:.| |:|||:|:.|:.:|..|....:||
Mouse  1163 SLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIIEVDGMDLRDASHEQAV 1227

  Fly   263 -AVMKSSSKLDMVVRT-----------AAGCDLFPGES-SGYNSSASS--VTGDQSPCWADAKSK 312
             |:.|:.:.:..:|::           :....|:|..| |..|..|.|  :|.||:|..::::::
Mouse  1228 EAIRKAGNPVVFMVQSIINRPRKSPLPSLPHSLYPKYSFSSTNPFADSLQLTTDQAPSQSESETE 1292

  Fly   313 R--LTAVREES----GAGGGGCGLSSAPGAGSP---------NWSQGVEVHKQMNKT--IIKLTE 360
            :  |..|...|    ...|..|...||......         :|....|.:..:...  :|:|.:
Mouse  1293 KPALCNVPPSSPSVFSEMGSDCAQPSATAVSEDEDKEDEFGYSWKNIQERYGSLTGQLHVIELEK 1357

  Fly   361 NGTSINNTYIASTGGSSVS----GSGSTG-SGTSGRSQ---------------QSQSNPSN---- 401
            ..:.:..:...:...:.:|    |...|| :|..||.|               :|..|.|:
Mouse  1358 GQSGLGLSLAGNKDRTRMSVFIVGIDPTGAAGRDGRLQIADELLEINGQILYGRSHQNASSIIKC 1422

  Fly   402 -PS-------RNSTTMKRSHLRPVNSAGSGIGLSSGSAGSAGSAGSSGSGSRSGGVIAPAPAPPP 458
             ||       ||:..:.:..:.|               |.|..:.||.|.|.....:.|...
Mouse  1423 APSKVKIIFIRNADAVNQMAVCP---------------GIAADSPSSTSDSPQNKEVEPCST--- 1469

  Fly   459 PAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNRDRDRDG-----------NGNVD 512
                  .:||.:..|||:.....||.|                  |:.|           ||.:.
Mouse  1470 ------TSASAADLSSLTDVYQLELPK------------------DQGGLGIAICEEDTINGVMI 1510

  Fly   513 RQLTGHNG--------NGGH---------------------RSSVGQVSHRQRAN------VAGV 542
            ..||.|.|        .|.|                     :::...|....||.      |...
Mouse  1511 ESLTEHGGAAKDGRLKPGDHILAVDDEVVAGCPVEKFISLLKTAKATVKLTVRAENPACPAVPSS 1575

  Fly   543 AATLQGSER----------------------------------------------ISNLTGGGGA 561
            |.|:.|..:                                              ||....|.|.
Mouse  1576 AVTVSGERKDNSQTPAVPAPDLEPIPSTSRSSTPAVFASDPATCPIIPGCETTIEISKGQTGLGL 1640

  Fly   562 GGAGGSNGAAGA-------------------GGDQ-------------HTALMDEFKRAHQR--- 591
            ...|||:...||                   .|||             |...::..::..||
Mouse  1641 SIVGGSDTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRL 1705

  Fly   592 -MFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKN-----------GGSGGGEGSGVMPTM 644
             ::|:.....|..:.......|..|...|..:|::..:|           ||....:|. :|...
Mouse  1706 TLYRDEAPYKEEDVCDTFTIELQKRPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGR-LMQGD 1769

  Fly   645 RPVSMGRPLVTMSTYQERGETLK-----------RTSIMPDESCYRNSINSNNN----------- 687
            :.:.:....|..:|.:.....||           |....|..|..|.|.:|..:
Mouse  1770 QILMVNGEDVRHATQEAVAALLKCSLGAVTLEVGRVKAAPFHSERRPSQSSQVSESSLSSFTPPL 1834

  Fly   688 NGFSRNRSNSNTNNNNRLQSQ----------------NGVNPANGNGSPELPPPPPQFANPQPKQ 736
            :|.:.:.|..:.:..|.|.|:                .|::.|.|.||| |...|...|...|..
Mouse  1835 SGINTSESLESNSKKNALASEIQGLRTVEIKKGPADSLGLSIAGGVGSP-LGDVPIFIAMMHPNG 1898

  Fly   737 MPPQHIKPMTGNAAANGSG-SANGLGNGSLAKVRQPMSPMRSASISV------GGFRPPATPQPD 794
            :..|..|...|:......| |.:|:.:      .|.::.|::||.|:      ||.....|....
Mouse  1899 VAAQTQKLRVGDRIVTICGTSTDGMTH------TQAVNLMKNASGSIEVQVVAGGDVSVVTGHQQ 1957

  Fly   795 YDAVQIRSSQG--SESVSGRDVATSQQQRRTL-----RLGTVTIGEYGDQRTTGKRETLRKT--- 849
            ..|....:..|  |.|:...|:...|.:..||     .||...:|.||...  |......||
Mouse  1958 ELANPCLAFTGLTSSSIFPDDLGPPQSKTITLDRGPDGLGFSIVGGYGSPH--GDLPIYVKTVFA 2020

  Fly   850 NGEPASNGILKNG 862
            .|..|.:|.||.|
Mouse  2021 KGAAAEDGRLKRG 2033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	22/70 (31%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	26/89 (29%)
Mpdz	NP_001292213.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..372
		PDZ	375..464	CDD:214570
		PDZ_signaling	553..622	CDD:238492
		PDZ_signaling	694..777	CDD:238492
		PDZ_signaling	994..1064	CDD:238492	25/108 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1144		5/18 (28%)
		PDZ_signaling	1151..1242	CDD:238492	28/97 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1313		8/34 (24%)
		PDZ	1349..1434	CDD:214570	15/84 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1449..1473		5/32 (16%)
		PDZ_signaling	1483..1563	CDD:238492	14/97 (14%)
		MPDZ_u10	1564..1625	CDD:293272	5/60 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1571..1611		4/39 (10%)
		PDZ	1626..1710	CDD:214570	15/83 (18%)
		PDZ_signaling	1722..1802	CDD:238492	13/80 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1809..1848		7/38 (18%)
		PDZ_signaling	1859..1944	CDD:238492	21/91 (23%)
		PDZ_signaling	1985..2068	CDD:238492	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810