Protein Alignment CG5921 and Grip2

DIOPT Version :9

• Sequence 1: NP_727061.2
• Gene: CG5921 / 31538
• FlyBaseID: FBgn0029835
• Length: 886
• Species: Drosophila melanogaster
• Sequence 2: NP_612544.2
• Gene: Grip2 / 171571
• RGDID: 621668
• Length: 1043
• Species: Rattus norvegicus
• Alignment Length: 1130
• Identity: 204/1130 - (18%)
• Similarity: 327/1130 - (28%)
• Gaps: 481/1130 - (42%)

  Fly    54 AIPASSR-LRVLRLVRPHQRRLLVGGPERGSTYGFTVRGGREHGTGFFVSHVEHGG-EAHLKGLR 116
            :||...| :.::.|::           ..|||.|.|:.||.:......||::..|| .|....|.
  Rat    43 SIPEEFRGITMVELIK-----------REGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLN 96

  Fly   117 IGDQILRINGFRLDDAVHKEFIQLVAG-QDRVTLKV----------------------------- 151
            :||.|..:||.||....|.|.|.|:.. .:||.|:|
  Rat    97 VGDYIRSVNGIRLTRLRHDEIITLLKNVGERVVLEVEYELPPPAPENNPRIISKTVDVSLYKEGN 161

  Fly   152 ------RG-------------------------VGMLPVRDLPEERLSWSVVKLPSVSGTP---- 181
                  ||                         .|.|.|.|           :|.|:.|.|
  Rat   162 SFGFVLRGGAHEDLHKSRPLVLTYVRPGGPADREGSLKVGD-----------RLLSIDGIPLHGA 215

  Fly   182 -------------SESSFKGERRGASRDI------SVVLHVA--PRTKLGLGICKGPEW-KPGIF 224
                         .|:.|:.|...|:.|.      .:|:.:|  |.:.||:.:..|... ||.|.
  Rat   216 SHATAIATLQQCSHEALFQVEYDVATPDTVANASGPLVVEIAKTPGSALGISLTTGSHRNKPAIT 280

  Fly   225 VQFTKDRSVA-REAGLRPGDQILSVNSIDFSDVLFSEAVAVMKSSS---KLDMVVRTAAGCDLFP 285
            :...|..||. |...|..||.||:::..........||..::.|.:   :|:::....:...|.|
  Rat   281 IDRIKPASVVDRSGALHAGDHILAIDGTSTEHCSLVEATKLLASVTEKVRLEILPAPQSRRPLKP 345

  Fly   286 GESSGYNSSASSVTGDQSPCWADAKSKRLTAVREESGAGGGGCGLSSAPGAGSPNWSQGVEVHKQ 350
            .|:.....|......|  ||.....|.|.:..|                   :|.|:.|.:
  Rat   346 PEAVRIQRSEQLHHWD--PCVPSCHSPRPSHCR-------------------APTWAPGGQ---- 385

  Fly   351 MNKTIIKLTENGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQSNPSNPSRNSTTMKRSHLR 415
                     :...|:::|..:|                      ...||:.|..|::|:.|..:.
  Rat   386 ---------DQSRSVSSTPFSS----------------------PTMNPAFPCANASTLPRGPMS 419

  Fly   416 PVNSAG----------SGIGLSSGSAGSAGS-----------AGS--SGSGSR-SGGVIAPAPAP 456
            |..:||          |.:.|:|.:.|..|.           .|.  ||.|.: .||:.|.....
  Rat   420 PRTTAGRRRQRRKEHRSSLSLASSTVGPGGQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLS 484

  Fly   457 PPP------------------------AMN---------EGAN---------------------- 466
            .||                        |:|         |.||
  Rat   485 SPPLVRFIEPDSPAERCGLLQVGDRVLAINGIATEDGTMEEANQLLRDAALARKVVLEIEFDVAE 549

  Fly   467 ----ASGSV--------GSSLSSAITEELKKRKE-------KQQQQQHQQRHNRDRD-------- 504
                :||:.        |..|...|:...:||.|       |:....|:.......|
  Rat   550 SVIPSSGTFHVKLPKRRGVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNI 614

  Fly   505 --------------RDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQRANVAG--VAATLQGSER-- 551
                          |.....|..::.....|...:.|.|.||:.......|  :..|:.|:|.
  Rat   615 RLDHCPMEYAVQILRQCEDLVKLKIRKDEDNSDEQESSGAVSYTVELKRYGGPLGITISGTEEPF 679

  Fly   552 ----ISNLTGGGGAGGAGGSNGAAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSL 612
                ||.||..|.|...|..:     .||:..|:                            :|:
  Rat   680 DPIIISGLTKRGLAERTGAIH-----VGDRILAI----------------------------NSV 711

  Fly   613 ADRSLYGREMS----LLRVKNGGSGGGEGSGVMPTMR-PVSMGRPLV---------TMSTYQERG 663
               ||.||.:|    ||:|          :|...|:: ...:.|||:         .....::..
  Rat   712 ---SLKGRPLSEAIHLLQV----------AGETVTLKIKKQLDRPLLPRQSGSLSEASDVDEDPP 763

  Fly   664 ETLK----RTSIMPD----ESCYRNSINSNNNNGFSRNRSNSNTNNNNRLQSQNGVNPANGNGSP 720
            |.||    .|...|.    :|...:..:|....||.                      .:|:.:|
  Rat   764 EALKGGLLTTHFSPAVPSVDSAVESWGSSATEGGFG----------------------GSGSYTP 806

  Fly   721 EL---PPPPPQFANPQPKQMPPQHIKPMTGNAAANGSGSANGLGNGSLAKVRQPMSPMRSA---- 778
            ::   ...|.::.:.:.|..||                               |:.|.|::
  Rat   807 QVAVRSVTPQEWRSSRLKSSPP-------------------------------PLEPRRTSYTPG 840

  Fly   779 -------SISVGGFRPPATPQP-----------------------------DYDAVQIRSSQGSE 807
                   ....|.:.||.:|.|                             :.:|..:..:..|.
  Rat   841 PTDESFPEEEEGDWEPPMSPAPGPAREEGFWRVLGEALEDLESCGQSELLRELEASIMTGTVQSV 905

  Fly   808 SVSG----------RDVATSQQQRRTLRLGTVTIGEYGDQRTTGKRETLRKTNGEPASNGILKNG 862
            :|.|          |:|.||.:..:.|.|.|    .....|.|..::.:|...|...|:|:|:.|
  Rat   906 AVDGRPGSRPWRRSREVGTSPEDLQELLLPT----PLEMHRVTLHKDPVRNDFGFSVSDGLLEKG 966

  Fly   863 ----SNRSSASFNHGSSHQTEKTIK 883
                :.|......||.....::.::
  Rat   967 VYVHTVRIDGPAQHGGLQPFDRLLQ 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	28/106 (26%)
		PDZ_signaling	197..276	CDD:238492	22/91 (24%)
Grip2	NP_612544.2	PDZ_signaling	51..133	CDD:238492	28/92 (30%)
		PDZ_signaling	153..236	CDD:238492	12/93 (13%)
		PDZ_signaling	251..334	CDD:238492	22/82 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..450		21/132 (16%)
		PDZ_signaling	456..544	CDD:238492	14/87 (16%)
		PDZ_signaling	557..640	CDD:238492	11/82 (13%)
		PDZ_signaling	657..737	CDD:238492	25/125 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	745..769		3/23 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	786..863		16/129 (12%)
		PDZ_signaling	941..1020	CDD:238492	11/51 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900