DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5921 and Grid2ip

DIOPT Version :9

Sequence 1:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster
Sequence 2:	NP_001152793.1	Gene:	Grid2ip / 170935	MGIID:	2176213	Length:	1203	Species:	Mus musculus

Alignment Length:	874	Identity:	161/874 - (18%)
Similarity:	252/874 - (28%)	Gaps:	344/874 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 GGPER-------GSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKGLRIGDQILRINGFRLDDAVH 134
            |||.|       ..::|||:||   ||. .::..|..|..|....|:.||:||.:||..:.:..|
Mouse   263 GGPRRTVRVYKGNKSFGFTLRG---HGP-VWIESVLPGSPAENASLKSGDRILFLNGLDMRNCSH 323

  Fly   135 KEFIQLVAGQDRVTLKVRGVGMLPVR------DLPEE-----RLSWSVVKLPSVSGTPSESSFKG 188
            .:.:.::.|...:...|...|.:|..      |.|..     .|.|....||        ||.:.
Mouse   324 DKVVSMLQGSGAMPTLVVEEGPVPFASDSDSLDSPTRASALTSLQWVADILP--------SSIRV 380

  Fly   189 ERRGASRDISVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAREAGLRPGDQILSVNSIDF 253
            :.|..|:.:..:|....|    .|:|:..|       :|.:.|::         |.::    :|.
Mouse   381 QGRTFSQQLDHLLTPPER----YGVCRALE-------RFFQHRNI---------DTLI----VDV 421

  Fly   254 SDVLFSEA------------------------------VAVMKSSSKLDM--------------- 273
            ..||.:.|                              .|:.:..|.||:
Mouse   422 YPVLDTPAKQVLWQFLYQLLTYEEQELCQEKIACFLGYTAMTEPESSLDLEPESTPEPTPEPQPR 486

  Fly   274 -VVRTAAGC--DLFPGESSGYNSSASSVTGD--QSPCWADAKSKRLTAVREESGAGGGGCGLSSA 333
             .:|.::.|  .|   .|.|..:|.|...||  :.|         |..:..|..||.|    :|.
Mouse   487 SSLRASSMCRRSL---RSQGLETSLSCGPGDCPEMP---------LPLIPGERQAGDG----TSL 535

  Fly   334 PGAGSPNWSQGV--EVHKQMNKTIIKLTENGTSINNTYIASTGGSSVSGSGSTGSGTSGRSQQSQ 396
            |...:|.....|  |:..::|                              |:..|..|...:|:
Mouse   536 PETPNPKMMSAVYAELESRLN------------------------------SSFKGKIGTMSKSR 570

  Fly   397 SNPSNPSRNSTTMKRSHLRPVNSAGSGIG--------------LSSGSAGSAGSAGS----SGSG 443
            ::|..||...|:..|:.        ||:.              |.||...|..|:.|    |...
Mouse   571 ASPPVPSLVGTSGPRTL--------SGVSWPSDRLLPSPCYDPLCSGGLASPSSSESHPYASLDS 627

  Fly   444 SRS-------GGVIAPAPAPPPPAMNEGANASGSVGSSLSSAITEELKKRKEKQQQQQHQQRHNR 501
            ||:       |.:.|.:|..|.|.                         |...:::.....|..|
Mouse   628 SRAPSPQPGLGSIHADSPPSPDPI-------------------------RPPSRRKLFAFSRPVR 667

  Fly   502 DRDRDGNGNVDRQLTGHNGNGGHRSSVGQVSHRQRANVAGVAATLQGSERISNLTGGGGAGGAGG 566
            .||      .||.|...:...|.|.|:
Mouse   668 SRD------TDRFLDALSEQLGPRLSI-------------------------------------- 688

  Fly   567 SNGAAGAGGDQHTALMDEFKRAHQRMFRNGFHESEHKLSSLGKSSLADRSLYGREMSLLRVKNGG 631
                           :|:|...........||:.:....:..:||.::..
Mouse   689 ---------------VDDFLTPENDYEEMSFHDDQGSFVTNERSSASECV--------------- 723

  Fly   632 SGGGEGSGVMPTMRPVSMGRPLVTMSTYQERGETLKRTSIMPDESCYRNSINSNNNNGFSRNRSN 696
            |...|||.:                 ||....:.:....:.|...         ....|...:.:
Mouse   724 SSSEEGSSL-----------------TYSSISDHIPPPPLSPPPP---------PPLPFHDPKPS 762

  Fly   697 SNTNNNNRLQSQNGVNPANGNGSPELPPPPPQFANPQPKQMPP---------------QHIKPMT 746
            |.|::..|...|:...|......|..|||||....|.| ..||               ..:|.:.
Mouse   763 SRTSDGPRGPPQSLTKPLTQINHPVPPPPPPPLPPPVP-CAPPMLSRGVGHRRSETSHMSVKRLR 826

  Fly   747 GNAAANGSGSANG-LGNGSLAKVRQPMSPMRSASISVGGFRPPAT---PQP--DYDAVQIRSSQG 805
            .....|..|:..| ||..|.......|.......:..|..:||..   |:|  ..:.|:|.|.:.
Mouse   827 WEQVENSEGTIWGQLGEDSDYDKLSDMVKYLDLELHFGTQKPPKPVPGPEPFRKKEVVEILSHKK 891

  Fly   806 SESVS----------G--RDVATSQQQRR 822
            :.:.|          |  |.|..|.:.||
Mouse   892 AYNTSILLAHLKLTPGELRQVLMSMEPRR 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	19/69 (28%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	16/124 (13%)
Grid2ip	NP_001152793.1	PDZ_signaling	9..69	CDD:238492
		HN_L-delphilin-R1_like	122..201	CDD:259820
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..270		4/6 (67%)
		PDZ_signaling	269..342	CDD:238492	20/76 (26%)
		HN_L-delphilin-R2_like	378..457	CDD:259821	14/102 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..541		20/90 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..586		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..656		12/69 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..821		25/152 (16%)
		FH2	812..1180	CDD:280362	23/109 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900